{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:07:22Z","timestamp":1790305642994,"version":"4.1.0"},"reference-count":68,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:00:00Z","timestamp":1500249600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2017,7,29]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Possession of APOE \u025b4 is a strong risk factor for late-onset Alzheimer\u2019s disease and is associated with loss of synaptic proteins in the elderly even in the absence of Alzheimer\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We hypothesized that \u025b4 allele possession in non-demented adults aged under-75 would also be associated with alterations in the levels of synaptic proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We measured synaptophysin, PSD95, drebrin, SNAP-25, and septin 7 by ELISA in hippocampus and superior temporal gyrus from 103 adults aged\u200a&lt;75 without dementia. Corresponding gene expression was measured by RT-PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There was no evidence that \u025b4 affected levels of the proteins measured. Instead we found an increase in post-synaptic proteins in the hippocampi of those with an \u025b32 genotype. The evidence was strongest for drebrin ( p\u200a=\u200a0.011). There was some evidence of increased synaptic protein gene expression in \u025b4 carriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>People with an APOE \u025b32 genotype have a reduced risk of Alzheimer\u2019s disease. It may be relevant that they have a higher level of post-synaptic proteins in the hippocampus even in earlier adulthood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-170316","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T10:54:57Z","timestamp":1500375297000},"page":"1123-1137","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of APOE Genotype on Synaptic Proteins in Earlier Adult Life"],"prefix":"10.1177","volume":"59","author":[{"given":"Lindsey I.","family":"Sinclair","sequence":"first","affiliation":[{"name":"School of Social and Community Medicine, University of Bristol, Oakfield House, Clifton, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Love","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences, University of Bristol, Level 1 Learning and Research Building, Southmead Hospital, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,7,17]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.02.003"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300410"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1038\/ng.803"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1038\/ng1934"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000137041.86153.42"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1038\/1206"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1038\/ng0694-180"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92557-7"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.6.862"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000343853.00346.a4"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051080"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.02.003"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.02.016"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4612-13.2014"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1998.6860"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.12.023"},{"key":"ref017","unstructured":"Uniprot, Consortium, UniProtKB, http:\/\/www.uniprot.org, Accessed 19\/11\u20132012."},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80082-9"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.04.008"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6940"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2006.05.004"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-200606000-00007"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64573-7"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-16"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22219"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2008.01.006"},{"key":"ref027","unstructured":"NCBI, Entrez Gene, http:\/\/www.ncbi.nlm.nih.gov\/gene\/, 18\/08\/2010, Accessed, 23\u20138."},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.05167.x"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19990101)20:4\/5<928::AID-ELPS928>3.0.CO;2-Z"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.06.035"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00285-9"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31827c5710"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2010.01150.x"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1159\/000333122"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1002\/path.1789"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.02.016"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.08.042"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12215"},{"key":"ref039","unstructured":"AshbyEL (2010) PhD Thesis, School ofClinical Sciences, University of Bristol, Bristol. 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