{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:46:08Z","timestamp":1791276368154,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2017,9,18]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objective:<\/jats:title>\n                    <jats:p>Mild cognitive impairment (MCI) patients with small vessel disease (SVD) are at high dementia risk. We tested the effects of cognitive rehabilitation in these patients using the Attention Process Training-II (APT-II) program in a single-blinded, randomized clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients were randomized to APT-II or standard care and evaluated at baseline, 6, and 12 months with functional, quality of life, cognitive tests, and resting state functional MRI (rsfMRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Forty-six patients were enrolled and 43 (mean\u00b1SD age 75.1\u00b16.8) completed the study. No change was seen in functionality and quality of life between treated and non-treated patients. However, the Rey Auditory-Verbal Learning Test immediate recall showed a significant improvement in treated compared to non-treated group (change score 6 versus 12 months: 1.8\u00b14.9 and \u20131.4\u00b13.8, p\u200a=\u200a0.021; baseline versus 12 months: 3.8\u00b16.1 and 0.2\u00b14.4, p\u200a=\u200a0.032). A higher proportion of treated patients had stable\/better evaluation compared to non-treated group on Visual search test (6 versus 12 months: 95% versus 71%, p\u200a=\u200a0.038) and Rey\u2013Osterrieth Complex Figure copy (6 versus 12 months: 95% versus 67%, p\u200a=\u200a0.027). RsfMRI, performed in a subsample, showed that the difference between follow-up and baseline in synchronization of activity in cerebellar areas was significantly greater in treated than in non-treated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We were unable to show a significant effect in quality of life or functional status in treated patients with MCI and SVD. However, APT-II produces some beneficial effects in focused attention and working memory and seems to increase activity in brain circuits involved in cognitive processes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-170428","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T13:44:03Z","timestamp":1504273443000},"page":"615-624","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Effect of Attention Training in Mild Cognitive Impairment Patients with Subcortical Vascular Changes: The RehAtt Study"],"prefix":"10.1177","volume":"60","author":[{"given":"Leonardo","family":"Pantoni","sequence":"first","affiliation":[{"name":"NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Poggesi","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Diciotti","sequence":"additional","affiliation":[{"name":"Department of Electrical, Electronic, and Information Engineering \u2018Guglielmo Marconi\u2019, University of Bologna, Cesena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Valenti","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Orsolini","sequence":"additional","affiliation":[{"name":"Department of Electrical, Electronic, and Information Engineering \u2018Guglielmo Marconi\u2019, University of Bologna, Cesena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Della Rocca","sequence":"additional","affiliation":[{"name":"Stroke Unit, Azienda Ospedaliero Universitaria Careggi, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Inzitari","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy"},{"name":"Institute of Neuroscience, Italian National Research Council, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Mascalchi","sequence":"additional","affiliation":[{"name":"\u2018Mario Serio\u2019 Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy"},{"name":"Quantitative and Functional Neuroradiology Research Program at Meyer Children Hospital and Careggi General Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Salvadori","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt4"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.605097"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00305-3"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.4.714"},{"key":"ref005","volume-title":"Attention Process Training-II (APT-II)","author":"Sohlberg 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