{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T21:50:31Z","timestamp":1785534631000,"version":"3.56.0"},"reference-count":72,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"<jats:p>\n                    We had an opportunity to assess the change observed in the brain regarding Alzheimer\u2019s disease (AD)-related alterations, cell count, and inflammation that took place during a period of 21 months in a subject with a definite diagnosis of AD and idiopathic Normal Pressure Hydrocephalus (iNPH). Four neuronal markers, i.e., synaptophysin, microtubule associated protein 2, non-phosphorylated neurofilament H (SMI32), and embryonic lethal abnormal visual system proteins 3\/4 HuC\/HuD (HuC\/HuD); three microglial markers CD68, Human Leucocytic Antigen DR, ionized calcium-binding adaptor molecule 1, glial fibrillary acidic protein (GFAP); and AD-related markers, hyperphosphorylated \u03c4 (HP \u03c4) and amyloid-\u03b2 (A\u03b2, A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    , A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    ) were assessed. Morphometrically assessed immunoreactivity of all neuronal and all microglial markers and A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    decreased parallel with an increase in the HP \u03c4 in the frontal cortex. The expression of GFAP was stable with time. The first sample was obtained during the therapeutic shunting procedure for iNPH, and the second sample was obtained postmortem. Negligible reactive changes were observed surrounding the shunt channel. In conclusion, in the late stage of AD with time, a neuronal loss, increase in the HP \u03c4, and decrease in A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    and microglia was observed, whereas the expression of GFAP was rather stable. The observations described here suggest that when a brain biopsy has been obtained from an adult subject with iNPH, the assessment of postmortem brain is of major significance.\n                  <\/jats:p>","DOI":"10.3233\/jad-170446","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T11:31:14Z","timestamp":1516707074000},"page":"1451-1462","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Progression of Alzheimer\u2019s Disease-Related Pathology and Cell Counts in a Patient with Idiopathic Normal Pressure Hydrocephalus"],"prefix":"10.1177","volume":"61","author":[{"given":"Sylwia","family":"Libard","sequence":"first","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Uppsala University, Sweden"},{"name":"Department of Pathology, Uppsala University Hospital, 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