{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:54:14Z","timestamp":1780433654902,"version":"3.54.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2017,10,3]]},"DOI":"10.3233\/jad-170491","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T06:10:42Z","timestamp":1507097442000},"page":"1183-1193","source":"Crossref","is-referenced-by-count":37,"title":["Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"60","author":[{"given":"Stella M.","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"Service of Psychiatry, FLENI Foundation, Buenos Aires, Argentina"},{"name":"National Council for Scientific and Technological Research (CONICET), Argentina"},{"name":"Department of Physics (FCEyN), University of Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Abulafia","sequence":"additional","affiliation":[{"name":"Service of Psychiatry, FLENI Foundation, Buenos Aires, Argentina"},{"name":"National Council for Scientific and Technological Research (CONICET), Argentina"},{"name":"Institute for Biomedical Research (BIOMED), Pontifical Catholic University of Argentina, and The National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Duarte-Abritta","sequence":"additional","affiliation":[{"name":"Service of Psychiatry, FLENI Foundation, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Soledad Ladr\u00f3n","family":"de Guevara","sequence":"additional","affiliation":[{"name":"Service of Psychiatry, FLENI Foundation, Buenos Aires, Argentina"},{"name":"National Council for Scientific and Technological Research (CONICET), Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana N.","family":"Castro","sequence":"additional","affiliation":[{"name":"Service of Psychiatry, FLENI Foundation, Buenos Aires, Argentina"},{"name":"National Council for Scientific and Technological Research (CONICET), Argentina"},{"name":"Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Drucaroff","sequence":"additional","affiliation":[{"name":"Service of Psychiatry, FLENI Foundation, Buenos Aires, Argentina"},{"name":"National Council for Scientific and Technological Research (CONICET), Argentina"},{"name":"Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Sevlever","sequence":"additional","affiliation":[{"name":"Department of Neuropathology and Molecular Biology, FLENI Foundation, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B.","family":"Nemeroff","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E.","family":"Vigo","sequence":"additional","affiliation":[{"name":"National Council for Scientific and Technological Research (CONICET), Argentina"},{"name":"Institute for Biomedical Research (BIOMED), Pontifical Catholic University of Argentina, and The National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Loewenstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirta F.","family":"Villarreal","sequence":"additional","affiliation":[{"name":"Service of Psychiatry, FLENI Foundation, Buenos Aires, Argentina"},{"name":"National Council for Scientific and Technological Research (CONICET), Argentina"},{"name":"Department of Physics (FCEyN), University of Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador M.","family":"Guinjoan","sequence":"additional","affiliation":[{"name":"Service of Psychiatry, FLENI Foundation, Buenos Aires, Argentina"},{"name":"National Council for Scientific and Technological Research (CONICET), Argentina"},{"name":"Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine, Argentina"},{"name":"Neurophysiology I, University of Buenos Aires School of Psychology, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-170491_ref1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jalz.2016.02.002","article-title":"Preclinical Alzheimer\u2019s disease:Definition, natural history, and diagnostic criteria","volume":"12","author":"Dubois","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-170491_ref2","first-page":"146","article-title":"\u00dcber eine eigenartige Erkrankung derHirnrinde","volume":"64","author":"Alzheimer","year":"1907","journal-title":"Allg Zschr Psychiatr Psych Gerichtl Med"},{"key":"10.3233\/JAD-170491_ref3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: The amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.3233\/JAD-170491_ref4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/alzrt269","article-title":"Alzheimer\u2019s diseasedrug-development pipeline: Few candidates, frequent failures","volume":"6","author":"Cummings","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-170491_ref5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-170491_ref6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00401-010-0789-4","article-title":"The pathological process underlying Alzheimer\u2019s disease in individuals under thirty","volume":"121","author":"Braak","year":"2011","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-170491_ref7","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.neubiorev.2016.12.020","article-title":"Neurophysiological assessment of neural network plasticity and connectivity: Progress towards early functional biomarkers for disease interception therapies in Alzheimer\u2019s disease","volume":"73","author":"Walsh","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"key":"10.3233\/JAD-170491_ref8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/ana.23643","article-title":"Alzheimer disease family history impacts resting state functional connectivity","volume":"72","author":"Wang","year":"2012","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-170491_ref9","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1002\/hbm.22379","article-title":"Functional connectivity changes differ in early and late-onset alzheimer\u2019s disease","volume":"35","author":"Gour","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-170491_ref10","unstructured":"Loewenstein DA , Curiel RE , Duara R , Buschke H (2017) Novel cognitive paradigms for the detection of memory impairment in preclinical Alzheimer\u2019s disease. Assessment. doi: 10.1177-1073191117691608"},{"key":"10.3233\/JAD-170491_ref11","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.jagp.2016.02.056","article-title":"A novel cognitive stress test for the detection of preclinical Alzheimer disease: Discriminative properties and relation to amyloid load","volume":"24","author":"Loewenstein","year":"2016","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-170491_ref12","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jagp.2013.01.066","article-title":"An evaluation of deficits in semantic cueing and proactive and retroactive interference as early features of Alzheimer\u2019s disease","volume":"22","author":"Crocco","year":"2014","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-170491_ref13","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3233\/JAD-160881","article-title":"Recovery from proactive semantic interference in mildcognitive impairment and normal aging: Relationship to atrophy inbrain regions vulnerable to Alzheimer\u2019s disease","volume":"56","author":"Loewenstein","year":"2017","journal-title":"J AlzheimersDis"},{"key":"10.3233\/JAD-170491_ref14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3233\/JAD-170276","article-title":"Recovery from proactive semantic interference and MRI volume: A replication and extension study","volume":"59","author":"Loewenstein","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-170491_ref15","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1212\/01.wnl.0000436078.95856.56","article-title":"Anterior nucleus of the thalamus: Functional organization and clinical implications","volume":"81","author":"Child","year":"2013","journal-title":"Neurology"},{"key":"10.3233\/JAD-170491_ref16","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th ed. American Psychiatric Association, Washington, DC.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"10.3233\/JAD-170491_ref17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.3233\/JAD-170491_ref18","volume-title":"The Halstead\u2013Reitan Neuropsycholgical Test Battery: Therapy and clinical interpretation","author":"Reitan","year":"1985"},{"key":"10.3233\/JAD-170491_ref19","unstructured":"Artiola L , Hermosillo D , Heaton R , Pardee RE (1999) Manual denormas y procedimientos para la bater\u00ed neuropsicol\u00f3gica en espa\u00f1ol [Manual of norms and procedures for the Spanish neuropsychologicalbattery]. M Press, Tucson, AZ."},{"key":"10.3233\/JAD-170491_ref20","volume-title":"The assessment of aphasia and related disorders","author":"Goodglass","year":"1983"},{"key":"10.3233\/JAD-170491_ref21","volume-title":"L\u2019Examen Clinique en Psychologie","author":"Rey","year":"1964"},{"key":"10.3233\/JAD-170491_ref22","volume-title":"Rey Auditory and Verbal Learning Test: A handbook","author":"Schmidt","year":"1996"},{"key":"10.3233\/JAD-170491_ref23","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3233\/JAD-160866","article-title":"Validation of the Spanish Version of the LASSI-L for diagnosingmild cognitive impairment and Alzheimer\u2019s disease","volume":"56","author":"Matias-Guiu","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-170491_ref24","first-page":"195","article-title":"Cognitive reserve questionnaire. Scores obtained in a healthy elderly population and in one with Alzheimer\u2019s disease","volume":"52","author":"Rami","year":"2011","journal-title":"Rev Neurol"},{"key":"10.3233\/JAD-170491_ref25","volume-title":"Co-planar stereotaxic atlas of the human brain. 3-Dimensional proportional system: An approach to cerebral imaging","author":"Talairach","year":"1988"},{"key":"10.3233\/JAD-170491_ref26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-170491_ref27","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-170491_ref28","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.3174\/ajnr.A3140","article-title":"Generation of individualized thalamus target maps by using statistical shape models and thalamocortical tractography","volume":"33","author":"Jakab","year":"2012","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.3233\/JAD-170491_ref29","doi-asserted-by":"crossref","first-page":"e68910","DOI":"10.1371\/journal.pone.0068910","article-title":"BrainNet Viewer: A NetworkVisualization Tool for Human Brain Connectomics","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"key":"10.3233\/JAD-170491_ref30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0006-8993(75)90205-X","article-title":"Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. II. Frontal lobe afferents","volume":"95","author":"Van Hoesen","year":"1975","journal-title":"Brain Res"},{"key":"10.3233\/JAD-170491_ref31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0006-8993(75)90206-1","article-title":"Some connections of the entorhinal(area 28) and perirhinal (area 35) cortices of the rhesus monkey.III. Efferent connections","volume":"95","author":"Van Hoesen","year":"1975","journal-title":"Brain Res"},{"key":"10.3233\/JAD-170491_ref32","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/cne.902640306","article-title":"The entorhinal cortex of the monkey: II. Cortical afferents","volume":"264","author":"Insausti","year":"1987","journal-title":"J Comp Neurol"},{"key":"10.3233\/JAD-170491_ref33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fnagi.2017.00093","article-title":"Relationship betweencognitive and sleep-wake variables in asymptomatic offspring ofpatients with late-onset Alzheimer\u2019s disease","volume":"9","author":"Abulafia","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JAD-170491_ref34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-\u03b2 and tau: The trigger and bullet in Alzheimer disease pathogenesis","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-170491_ref35","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1093\/brain\/awl089","article-title":"Familial risk for Alzheimer\u2019s disease alters fMRI activation patterns","volume":"129","author":"Bassett","year":"2006","journal-title":"Brain"},{"issue":"Pt 3","key":"10.3233\/JAD-170491_ref36","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/brain\/awl377","article-title":"Thetopography of grey matter involvement in early and late onsetAlzheimer\u2019s disease","volume":"130","author":"Frisoni","year":"2007","journal-title":"Brain"},{"key":"10.3233\/JAD-170491_ref37","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/JAD-2012-111934","article-title":"Early onset Alzheimer\u2019s disease is associated with adistinct neuropsychological profile","volume":"30","author":"Smits","year":"2012","journal-title":"J\u00a0Alzheimers Dis"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-170491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:04:58Z","timestamp":1777370698000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-170491"}},"subtitle":[],"editor":[{"given":"Jordi","family":"Matias-Guiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,10,3]]},"references-count":37,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/jad-170491","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,3]]}}}