{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:48:09Z","timestamp":1789015689975,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,10,7]],"date-time":"2017-10-07T00:00:00Z","timestamp":1507334400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,3,13]]},"abstract":"<jats:p>The New Criteria for the diagnosis of Alzheimer\u2019s disease (AD), published by a group of experts in 2007, have resulted in a revolution in the comprehension of the disease. Before 2007, the diagnosis of AD dementia was done through a process of exclusion: it was considered in the case of patients with a dementia syndrome without identified etiologies. This traditional algorithm had three major limitations that penalize the disease: 1) a low accuracy of the performance which may share responsibility for negative results in clinical trials; 2) a late identification of the patients only when they reach the threshold of dementia which may delay the activation of optimal care; and last but not least, 3) an absence of clear recognition of AD as a disease because of the lack of specific arguments for its identification. Since 2007, the disease has gained a clear definition based on positive evidence: a specific clinical phenotype (the amnestic syndrome of the hippocampal type) and the presence of biomarkers, considered as a biological signature of the disease. Thanks to these positive arguments, AD is a clinically and biologically well-delineated disease, no longer defined as \u201cprobable\u201d. It is now possible to certify that a given patient has or does not have the disease. Like diabetes, cancer, hyperthyroidism or any other disorder, AD has now a clear definition with well-defined borders. The disease has entered the world of medicine with identified diseases with a biological fingerprint. This is the story of this adventure that we will present now.<\/jats:p>","DOI":"10.3233\/jad-170536","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T15:32:23Z","timestamp":1507649543000},"page":"1059-1066","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":55,"title":["The Emergence of a New Conceptual Framework for Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"62","author":[{"given":"Bruno","family":"Dubois","sequence":"first","affiliation":[{"name":"Centre des Maladies Cognitives et Comportementales (IM2A), Institut du Cerveau et de la Moelle \u00e9pini\u00e8re (ICM), UMR-S975, AP-HP, Salp\u00eatri\u00e8re Hospital, Pierre et Marie Curie University, Paris, 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