{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:41:31Z","timestamp":1792705291809,"version":"4.5.0"},"reference-count":94,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There is a need to specify the profile of subjective cognitive decline in preclinical Alzheimer\u2019s disease (preAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To explore specific items of the Subjective Cognitive Decline Questionnaire (SCD-Q) that discriminate preAD from normal aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      68 cognitively normal older adults were classified as controls (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u200a=\u200a52) or preAD (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u200a=\u200a16) according to amyloid-\u03b2 (A\u03b2) levels. An exploratory factor analysis and item analysis of the SCD-Q were performed. Informant reports of the SCD-Q were used to corroborate the findings of self-reports. One-year neuropsychological follow-up was available.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Four SCD-Q factors were extracted: EM-factor (episodic memory), A-factor (attention), O-factor (organization), and L-factor (language). PreAD reported a significantly higher decline in L-factor (F(1)\u200a=\u200a6.49;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.014) and A-factor (F(1)\u200a=\u200a4.04;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.049) compared to controls, and showed a higher frequency of perceived decline in SCD-Q items related with language and executive tasks (\n                      <jats:italic toggle=\"yes\">Sig-items.<\/jats:italic>\n                      ) Significant discriminative powers for A\u03b2-positivity were found for L-factor (AUC\u200a=\u200a0.75;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.003) and A-factor (AUC\u200a=\u200a0.74;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.004). Informants in the preAD group confirmed significantly higher scores in L-factor and\n                      <jats:italic toggle=\"yes\">Sig-items<\/jats:italic>\n                      . A significant\n                      <jats:italic toggle=\"yes\">time<\/jats:italic>\n                      \u00d7\n                      <jats:italic toggle=\"yes\">group<\/jats:italic>\n                      interaction was found in the Semantic Fluency and Stroop tests, with the preAD group showing a decrease in performance at one-year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our results suggest that SCD-Q items related with language and executive decline may help in prediction algorithms to detect preAD. Validation in an independent population is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-170627","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T14:25:56Z","timestamp":1513088756000},"page":"689-703","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["Executive and Language Subjective Cognitive Decline Complaints Discriminate Preclinical Alzheimer\u2019s Disease from Normal Aging"],"prefix":"10.1177","volume":"61","author":[{"given":"Natalia","family":"Valech","sequence":"first","affiliation":[{"name":"Hospital Clinic","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e0","family":"Tort-Merino","sequence":"additional","affiliation":[{"name":"Hospital Clinic","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Coll-Padr\u00f3s","sequence":"additional","affiliation":[{"name":"Hospital Clinic","place":["Spain"]},{"name":"Institut d\u2019 Investigacions Biom\u00e8diques August pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Olives","sequence":"additional","affiliation":[{"name":"Hospital Clinic","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Clinic","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Rami","sequence":"additional","affiliation":[{"name":"Hospital Clinic","place":["Spain"]},{"name":"Institut d\u2019 Investigacions Biom\u00e8diques August pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Molinuevo","sequence":"additional","affiliation":[{"name":"Hospital Clinic","place":["Spain"]},{"name":"Institut d\u2019 Investigacions Biom\u00e8diques August pi i Sunyer (IDIBAPS), Barcelona, Spain"},{"name":"Barcelona Beta Brain Research Center","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.004"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70223-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.10.027"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4018"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219668.47116.e6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.5.758"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-014-0539-z"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0959259812000172"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150251"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2012.08.011"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.666"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.05.1764"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000234032.77541.a2"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826c1a8d"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130080"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016852"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2009.10.002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12038"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291704003162"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181df49fb"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610213000665"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140678"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1166(200011)15:11<983::AID-GPS238>3.0.CO;2-5"},{"key":"e_1_3_3_28_2","first-page":"P3","article-title":"Differentiating preclinical Alzheimer\u2019s disease from normal aging: The effects of age and amyloid on cognitive decline over 3.5 years","volume":"12","author":"Farrell ME","year":"2016","unstructured":"FarrellME, KennedyKM, RodrigueKM, WigGS, BischofGN, RieckJR, ChenX, FestiniSB, DevousMD, ParkDC (2016) Differentiating preclinical Alzheimer\u2019s disease from normal aging: The effects of age and amyloid on cognitive decline over 3.5 years. Alzheimers Dement 12, P3\u2013272.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3256"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2013.07.002"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2004.05.001"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150095"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150154"},{"key":"e_1_3_3_34_2","first-page":"23","article-title":"Qualitative and quantitative assessment of self-reported cognitive difficulties in nondemented elders:Association with medical help seeking, cognitive deficits and \u03b2-amyloid imaging","volume":"5","author":"La Joie R","year":"2016","unstructured":"La JoieR, PerrotinA, EgretS, PasquierF, TomadessoC, MezengeF, DesgrangesB, de la SayetteV, Ch\u00e9telatG (2016) Qualitative and quantitative assessment of self-reported cognitive difficulties in nondemented elders:Association with medical help seeking, cognitive deficits and \u03b2-amyloid imaging. Alzheimers Dement 5, 23\u201334.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_35_2","first-page":"119","volume-title":"Assessment in Geriatric Psychopharmacology","author":"McNair DM","year":"1983","unstructured":"McNairDM, KahnRJ (1983) Self-assessment of cognitive deficits. In Assessment in Geriatric Psychopharmacology, CrookT, FerrisS, BartusR, eds. Mark Powley Associates, New Canaan, pp. 119\u2013136."},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132027"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150117"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.251"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22628"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2009.03.005"},{"key":"e_1_3_3_42_2","volume-title":"Boston Naming Test","author":"Kaplan E","year":"1983","unstructured":"KaplanE, GoodglassH, WeintraubS (1983) Boston Naming Test, Lea & Febiger, Philadelphia."},{"key":"e_1_3_3_43_2","volume-title":"Boston Diagnostic Aphasia Examination-III Edition","author":"Goodglass H","year":"2000","unstructured":"GoodglassH, KaplanE, BarresiB (2000) Boston Diagnostic Aphasia Examination-III Edition, Pearson Canada Assessment Inc., Canada."},{"key":"e_1_3_3_44_2","volume-title":"Visual Object and Space Perception Battery (VOSP)","author":"Warrington E","year":"1991","unstructured":"WarringtonE, JamesM (1991) Visual Object and Space Perception Battery (VOSP), Thames Valley Test Co, Bury St. Edmunds."},{"key":"e_1_3_3_45_2","volume-title":"Trail Making Test (TMT)","author":"Reitan R","year":"1994","unstructured":"ReitanR (1994) Trail Making Test (TMT). Reitan Neuropsychology Laboratory, USA."},{"key":"e_1_3_3_46_2","volume-title":"Multilingual Aphasia Examination Manual","author":"Benton AL","year":"1976","unstructured":"BentonAL, HamsherK (1976) Multilingual Aphasia Examination Manual, University of Iowa, Iowa City."},{"key":"e_1_3_3_47_2","first-page":"266","article-title":"The Free and Cued Selective Reminding Test: Evidence of psychometric adequacy","volume":"51","author":"Grober E","year":"2009","unstructured":"GroberE, Ocepek-WeliksonK, TeresiJA (2009) The Free and Cued Selective Reminding Test: Evidence of psychometric adequacy. Psychol Sci Q 51, 266\u2013282.","journal-title":"Psychol Sci Q"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0054651"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610205001596"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.01.003"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.03956.x"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.06.015"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00296-3"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.08.279"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn113"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.12.011"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617706060863"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10064"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144130"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.107.s179.6.x"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828ab35d"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674370805300603"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0959259809990426"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00095"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00217-2"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.05.020"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.446"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012853"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22333"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22608"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079378"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a8418b"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617708080302"},{"key":"e_1_3_3_75_2","first-page":"S602","article-title":"Language in the preclinical stage of Alzheimer\u2019s Disease: Content and complexity in biographical narratives","volume":"7","author":"Schr\u00f6der J","year":"2011","unstructured":"Schr\u00f6derJ, WendelsteinB, FelderE (2011) Language in the preclinical stage of Alzheimer\u2019s Disease: Content and complexity in biographical narratives. Alzheimers Dement 7, S602.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617707070609"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70361-7"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000246"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00196-3"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.11.019"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1262"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.03.021"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp083"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.10.024"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70404-0"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2013.03.011"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg236"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200207000-00008"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.01.019"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0017474"},{"key":"e_1_3_3_91_2","first-page":"51","volume-title":"Handbook of Neuropsychology","author":"Balota DA","year":"2001","unstructured":"BalotaDA, FaustME (2001) Attention in dementia of the Alzheimer\u2019s type. In Handbook of Neuropsychology,BollerF, CappaS, eds. Elsevier Science, New York, pp. 51\u201380."},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.06.622"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141470"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1177\/1525740113520322"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.3109\/17549500903137256"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-170627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-170627","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-170627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:05:22Z","timestamp":1777370722000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-170627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,12]]},"references-count":94,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.3233\/JAD-170627"],"URL":"https:\/\/doi.org\/10.3233\/jad-170627","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,12]]}}}