{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:54:52Z","timestamp":1777395292824,"version":"3.51.4"},"reference-count":60,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2017,12,19]]},"DOI":"10.3233\/jad-170720","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T14:27:04Z","timestamp":1513088824000},"page":"631-644","source":"Crossref","is-referenced-by-count":28,"title":["Alzheimer-Like Pattern of Hypometabolism Emerges with Elevated Amyloid-\u03b2 Burden in Down Syndrome"],"prefix":"10.1177","volume":"61","author":[{"given":"Patrick J.","family":"Lao","sequence":"first","affiliation":[{"name":"Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"University of Wisconsin-Madison, Waisman Center, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben L.","family":"Handen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Instruction and Learning, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobey J.","family":"Betthauser","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"University of Wisconsin-Madison, Waisman Center, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iulia","family":"Mihaila","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison, Waisman Center, Madison, WI, USA"},{"name":"Department of Human Development and Family Studies, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigan L.","family":"Hartley","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison, Waisman Center, Madison, WI, USA"},{"name":"Department of Human Development and Family Studies, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana L.","family":"Tudorascu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Internal Medicine, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Bulova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Lopresti","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rameshwari V.","family":"Tumuluru","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhanabalan","family":"Murali","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"University of Wisconsin-Madison, Waisman Center, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chester A.","family":"Mathis","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd E.","family":"Barnhart","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles K.","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie C.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darlynne A.","family":"Devenny","sequence":"additional","affiliation":[{"name":"New York State Institute for Research in Developmental Disabilities, Staten Island, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sterling C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Medicine-Geriatrics, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Klunk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley T.","family":"Christian","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"University of Wisconsin-Madison, Waisman Center, Madison, WI, USA"},{"name":"Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-170720_ref1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jalz.2017.02.001","article-title":"2017 Alzheimer\u2019s disease facts and figures","volume":"13","author":"Alzheimer\u2019s, Association","year":"2017","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-170720_ref2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: The amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.3233\/JAD-170720_ref3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0896-6273(91)90052-2","article-title":"The molecular pathology of Alzheimer\u2019s disease","volume":"6","author":"Selkoe","year":"1991","journal-title":"Neuron"},{"key":"10.3233\/JAD-170720_ref4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-170720_ref5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: An updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-170720_ref6","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A\u03b2-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"key":"10.3233\/JAD-170720_ref7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-170720_ref8","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1007\/s00259-003-1194-1","article-title":"Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer\u2019s disease: A PET follow-up study","volume":"30","author":"Drzezga","year":"2003","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.3233\/JAD-170720_ref9","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1007\/s00259-008-0833-y","article-title":"Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer\u2019s disease","volume":"35","author":"Li","year":"2008","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.3233\/JAD-170720_ref10","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00259-008-1039-z","article-title":"FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer\u2019s disease","volume":"36","author":"Mosconi","year":"2009","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.3233\/JAD-170720_ref11","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1001\/jamaneurol.2013.1062","article-title":"Cross-sectional and longitudinal analysis of the relationship between A\u03b2 deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease","volume":"70","author":"Dor\u00e9","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-170720_ref12","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s00259-005-1762-7","article-title":"Brain glucose metabolism in the early and specific diagnosis of Alzheimer\u2019s disease","volume":"32","author":"Mosconi","year":"2005","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.3233\/JAD-170720_ref13","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer\u2019s disease: A prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-170720_ref14","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/302553","article-title":"Early-onset autosomal dominant Alzheimer disease: Prevalence, genetic heterogeneity, and mutation spectrum","volume":"65","author":"Campion","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.3233\/JAD-170720_ref15","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1001\/archneurol.2009.285","article-title":"High striatal amyloid \u03b2-peptide deposition across different autosomal Alzheimer disease mutation types","volume":"66","author":"Villemagne","year":"2009","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-170720_ref16","doi-asserted-by":"crossref","first-page":"E4502","DOI":"10.1073\/pnas.1317918110","article-title":"Regional variability of imaging biomarkers in autosomal dominant Alzheimer\u2019s disease","volume":"110","author":"Benzinger","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-170720_ref17","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer\u2019s disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N Engl J Med"},{"key":"10.3233\/JAD-170720_ref18","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1046\/j.1471-4159.1994.62031062.x","article-title":"Down\u2019s syndrome: Up-regulation of \u03b2-amyloid protein precursor and \u03c4 mRNAs and their defective coordination","volume":"62","author":"Oyama","year":"1994","journal-title":"J Neurochem"},{"key":"10.3233\/JAD-170720_ref19","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1056\/NEJM198906013202203","article-title":"Amyloid A4 protein and its precursor in Down\u2019s syndrome and Alzheimer\u2019s disease","volume":"320","author":"Rumble","year":"1989","journal-title":"N Engl J Med"},{"key":"10.3233\/JAD-170720_ref20","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrn3983","article-title":"A genetic cause of Alzheimer disease: Mechanistic insights from Down syndrome","volume":"16","author":"Wiseman","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"10.3233\/JAD-170720_ref21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2559.1988.tb02018.x","article-title":"Alzheimer\u2019s disease and Down\u2019s syndrome","volume":"13","author":"Mann","year":"1988","journal-title":"Histopathology"},{"key":"10.3233\/JAD-170720_ref22","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1365-2788.1997.tb00679.x","article-title":"The epidemiology of Alzheimer disease in intellectual disability: Results and recommendations from an international conference","volume":"41","author":"Zigman","year":"1997","journal-title":"J Intellect Disabil Res"},{"key":"10.3233\/JAD-170720_ref23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF02984413","article-title":"The relative effects of paternal and maternal age in mongolism","volume":"27","author":"Penrose","year":"1933","journal-title":"J Genet"},{"key":"10.3233\/JAD-170720_ref24","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1469-8749.2004.tb00483.x","article-title":"Clinical, social, and ethical implications of changing life expectancy in Down syndrome","volume":"46","author":"Bittles","year":"2004","journal-title":"Dev Med Child Neurol"},{"key":"10.3233\/JAD-170720_ref25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ddrr.1128","article-title":"Atypical aging in Down syndrome","volume":"18","author":"Zigman","year":"2013","journal-title":"Dev Disabil Res Rev"},{"key":"10.3233\/JAD-170720_ref26","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jalz.2011.09.229","article-title":"Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B","volume":"8","author":"Handen","year":"2012","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-170720_ref27","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jalz.2015.05.013","article-title":"The effects of normal aging on amyloid-\u03b2 deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B","volume":"12","author":"Lao","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-170720_ref28","first-page":"2","article-title":"Longitudinal changes in amyloid PET and volumetric MRI in the non-demented Down syndrome population","volume":"9","author":"Lao","year":"2017","journal-title":"Alzheimers Dement (Amst)"},{"issue":"7 Suppl","key":"10.3233\/JAD-170720_ref29","doi-asserted-by":"crossref","first-page":"P428","DOI":"10.1016\/j.jalz.2017.06.419","article-title":"[F-18]AV-1451 PET in non-demented adults with Down syndrome is related to both amyloid and cognition","volume":"13","author":"Cohen","year":"2017","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-170720_ref30","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1212\/01.WNL.0000098935.36984.25","article-title":"Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia","volume":"61","author":"Haier","year":"2003","journal-title":"Neurology"},{"key":"10.3233\/JAD-170720_ref31","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0197-4580(92)90096-G","article-title":"Nature of mental retardation and dementia in Down syndrome: Study with PET, CT, and neuropsychology","volume":"13","author":"Schapiro","year":"1992","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-170720_ref32","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.jalz.2015.01.006","article-title":"Florbetapir PET, FDG PET, and MRI in Down syndrome individuals with and without Alzheimer\u2019s dementia","volume":"11","author":"Sabbagh","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-170720_ref33","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1053-8119(03)00273-8","article-title":"A voxel-based morphometric study of nondemented adults with Down Syndrome","volume":"20","author":"White","year":"2003","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-170720_ref34","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-170720_ref35","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S1474-4422(10)70223-4","article-title":"Revising the definition of Alzheimer\u2019s disease: A new lexicon","volume":"9","author":"Dubois","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-170720_ref36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-170720_ref37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jalz.2010.03.002","article-title":"The Alzheimer\u2019s Disease Neuroimaging Initiative: Annual change in biomarkers and clinical outcomes","volume":"6","author":"Beckett","year":"2010","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-170720_ref38","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1212\/WNL.0b013e318246d67a","article-title":"Accelerated cortical atrophy in cognitively normal elderly with high \u03b2-amyloid deposition","volume":"78","author":"Ch\u00e9telat","year":"2012","journal-title":"Neurology"},{"key":"10.3233\/JAD-170720_ref39","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3233\/JAD-2012-121516","article-title":"Rapid decline in episodic memory in healthy older adults with high amyloid-\u03b2","volume":"33","author":"Lim","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-170720_ref41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00004728-199801000-00027","article-title":"Automated image registration: I. General methods and intrasubject, intramodality validation","volume":"22","author":"Woods","year":"1998","journal-title":"J Comput Assist Tomogr"},{"key":"10.3233\/JAD-170720_ref42","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2967\/jnumed.108.057612","article-title":"Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements","volume":"50","author":"McNamee","year":"2009","journal-title":"J Nucl Med"},{"key":"10.3233\/JAD-170720_ref43","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer\u2019s disease with Pittsburgh compound B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-170720_ref44","first-page":"1959","article-title":"Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: A comparative analysis","volume":"46","author":"Lopresti","year":"2005","journal-title":"J Nucl Med"},{"key":"10.3233\/JAD-170720_ref45","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/sj.jcbfm.9600146","article-title":"Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B","volume":"25","author":"Price","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.3233\/JAD-170720_ref46","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/nimg.1997.0290","article-title":"Multimodal image coregistration and partitioning\u2014 a unified framework","volume":"6","author":"Ashburner","year":"1997","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-170720_ref47","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0361-9230(86)90074-2","article-title":"The neurobiologie consequences of Down syndrome","volume":"16","author":"Coyle","year":"1986","journal-title":"Brain Res Bull"},{"key":"10.3233\/JAD-170720_ref48","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/ajmg.1320370755","article-title":"Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis","volume":"37","author":"Wisniewski","year":"1990","journal-title":"Am J Med Genet A"},{"key":"10.3233\/JAD-170720_ref49","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/brain\/awh101","article-title":"Age-related cortical grey matter reductions in non-demented Down\u2019s syndrome adults determined by MRI with voxel-based morphometry","volume":"127","author":"Teipel","year":"2004","journal-title":"Brain"},{"key":"10.3233\/JAD-170720_ref50","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13229-015-0001-8","article-title":"Atypical development of white matter microstructure of the corpus callosum in males with autism: A longitudinal investigation","volume":"6","author":"Travers","year":"2015","journal-title":"Mol Autism"},{"key":"10.3233\/JAD-170720_ref51","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/brain\/awm112","article-title":"3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer\u2019s disease","volume":"130","author":"Whitwell","year":"2007","journal-title":"Brain"},{"key":"10.3233\/JAD-170720_ref52","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuroimage.2013.01.015","article-title":"Classification of amyloid-positivity in controls: Comparison of visual read and quantitative approaches","volume":"71","author":"Cohen","year":"2013","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-170720_ref53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/brain\/awu173","article-title":"Cognitive functioning in relation to brain amyloid-\u03b2 in healthy adults with Down syndrome","volume":"137","author":"Hartley","year":"2014","journal-title":"Brain"},{"key":"10.3233\/JAD-170720_ref54","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neurobiolaging.2017.05.019","article-title":"Cognitive decline and brain amyloid-\u03b2 accumulation across 3-years in adults with Down syndrome","volume":"58","author":"Hartley","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-170720_ref57","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jalz.2015.07.490","article-title":"The pattern of amyloid accumulation in the brains of adults with Down syndrome","volume":"12","author":"Annus","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-170720_ref58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnbeh.2015.00239","article-title":"The down syndrome biomarker initiative (DSBI) pilot: Proof of concept for deep phenotyping of Alzheimer\u2019s disease biomarkers in down syndrome","volume":"9","author":"Rafii","year":"2015","journal-title":"Front Behav Neurosci"},{"key":"10.3233\/JAD-170720_ref59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neurobiolaging.2017.01.009","article-title":"The Down syndrome brain in the presence and absence of fibrillar \u03b2-amyloidosis","volume":"53","author":"Annus","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-170720_ref60","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0160-2896(95)90032-2","article-title":"Brain size and cerebral glucose metabolic rate in nonspecific mental retardation and Down syndrome","volume":"20","author":"Haier","year":"1995","journal-title":"Intelligence"},{"key":"10.3233\/JAD-170720_ref61","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3233\/JAD-2007-11110","article-title":"Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: Targets for nonpharmacological intervention","volume":"11","author":"Head","year":"2007","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-170720_ref62","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1001\/archneurol.2011.104","article-title":"Positron emission tomography of brain \u03b2-amyloid and tau levels in adults with down syndrome","volume":"68","author":"Nelson","year":"2011","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-170720_ref63","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.trci.2016.02.004","article-title":"Dissociation of Down syndrome and Alzheimer\u2019s disease effects with imaging","volume":"2","author":"Matthews","year":"2016","journal-title":"Alzheimers Dement (NY)"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-170720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:05:23Z","timestamp":1777370723000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-170720"}},"subtitle":[],"editor":[{"given":"Elizabeth","family":"Head","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,19]]},"references-count":60,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-170720","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,19]]}}}