{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:17:56Z","timestamp":1790821076412,"version":"4.1.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"<jats:p>Accumulating evidence suggests a diet high in protein and fiber may confer some protection against Alzheimer\u2019s disease (AD). However, no human studies to-date have assessed the relationship between protein and fiber intake, and plasma and brain amyloid-\u03b2 (A\u03b2). Consequently, this cross-sectional study, investigated the association of self-reported dietary intakes of protein and fiber, with plasma and brain A\u03b2 burden ( n\u200a=\u200a541, and n\u200a=\u200a162 respectively), in a well-characterized cohort of cognitively normal older adults, drawn from the larger Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. We observed 12.59 and 8.43 higher odds of \u2018high\u2019 brain A\u03b2 burden (PiB PET SUVR\u22651.5) if protein intake fell in the lowest and middle tertile, respectively, compared to the highest tertile ( p\u200a=\u200a0.008; p\u200a=\u200a0.013). Thus, in this cohort, the more protein consumed, the less likelihood of \u2018high\u2019 A\u03b2 burden in the brain. No other significant associations were observed. The results of this study highlight the potentially protective impact of high dietary protein intake on brain A\u03b2 burden in older adults, before objective memory decline is apparent. While longitudinal validation is required, these findings may assist in the development of dietary approaches aimed at preventing or delaying AD onset.<\/jats:p>","DOI":"10.3233\/jad-170742","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T11:32:23Z","timestamp":1516707143000},"page":"1589-1598","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Associations of Dietary Protein and Fiber Intake with Brain and Blood Amyloid-\u03b2"],"prefix":"10.1177","volume":"61","author":[{"given":"W.M.A.D. 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