{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:43:45Z","timestamp":1790401425204,"version":"4.1.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,3,27]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      On target\n                      <jats:sup>18<\/jats:sup>\n                      F-Flortaucipir (FTP) binding of Alzheimer\u2019s disease tau aggregates and off-target binding of melanocytes have been demonstrated with autoradiography.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to investigate the hypothesis that if binding in choroid plexus (CP) is due to melanocytes, the signal would be elevated in Black\/African American (B\/AA) compared to White (W) participants. In addition, we examined whether CP signal affects measurements in adjacent regions, and whether correcting for spill-in effects has an influence on associations between hippocampus (HC) FTP and amyloid or cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>FTP race differences in 147 Harvard Aging Brain Study participants (23 B\/AA, 124W) were examined in CP, HC, HC covaried for CP, amygdala, inferior temporal gyrus, entorhinal cortex, and fusiform regions. Associations between CP FTP and other regions-of-interest (ROIs) were probed to assess spill-in effects. A statistical regression approach to attenuate CP spill-in was tested by relating adjusted HC SUVR residuals and unadjusted HC SUVR to race, cognition and amyloid. All analyses were covaried for age, sex, education and amyloid deposition, and Bonferroni-corrected for multiple comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      B\/AA individuals had elevated CP and HC SUVR ( p\u200a&lt;\u200a0.007), whereas other ROI SUVR and HC SUVR covaried for CP SUVR did not show race differences ( p\u200a&gt;\u200a0.05). CP SUVR was associated with HC SUVR ( p\u200a&lt;\u200a10\n                      <jats:sup>\u201314<\/jats:sup>\n                      ), but with no other ROI SUVR ( p\u200a&gt;\u200a0.05). When adjusting HC SUVR for CP SUVR, no race differences in residual HC SUVR were detected, and relationships with amyloid and memory became apparent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Melanocyte FTP binding may account partially for high CP signal. This off-target binding affects mainly HC FTP measurements, which should be interpreted with caution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-170840","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T05:22:03Z","timestamp":1522214523000},"page":"1691-1702","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":78,"title":["<sup>18<\/sup>\n                    F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal"],"prefix":"10.1177","volume":"62","author":[{"given":"Christopher M.","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Radiology, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi I.L.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Radiology, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Marqui\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA, USA"},{"name":"MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Becker","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Radiology, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas V.","family":"Andrea","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Radiology, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Jin","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Radiology, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron P.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital, Boston, MA, USA"},{"name":"The Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Frosch","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA, USA"},{"name":"MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA, USA"},{"name":"C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"G\u00f3mez-Isla","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA, USA"},{"name":"MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reisa A.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA, USA"},{"name":"The Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women\u2019s Hospital, Boston, MA, USA"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Radiology, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women\u2019s Hospital, Boston, MA, USA"},{"name":"Harvard Medical School, Boston, MA, 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