{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:39:14Z","timestamp":1778704754078,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"<jats:p>Herein, we performed a gene expression profiling in a cohort of 10 mild cognitive impairment (MCI), subdivided, according to the analysis of cerebrospinal fluid biomarkers, in prodromal Alzheimer\u2019s disease (AD) and non-AD MCI, as compared with 27 AD patients and 24 controls, in order to detect early gene expression alterations. We observed a significant upregulation of insulin (INS) and INS Receptor (INSR) expression levels in AD both prodromal and fully symptomatic, as compared with controls, but not in MCI subjects. Our results suggest an early dysregulation of INS and INSR in AD pathogenesis and pave the way to a possible utility of these transcripts as peripheral biomarkers.<\/jats:p>","DOI":"10.3233\/jad-170861","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T11:33:01Z","timestamp":1516707181000},"page":"1289-1294","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Profiling of Specific Gene Expression Pathways in Peripheral Cells from Prodromal Alzheimer\u2019s Disease Patients"],"prefix":"10.1177","volume":"61","author":[{"given":"Maria","family":"Serpente","sequence":"first","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Neurodegenerative Disease Unit, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Fenoglio","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Neurodegenerative Disease Unit, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Maria Giulia","family":"Cioffi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Neurodegenerative Disease Unit, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Oldoni","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Neurodegenerative Disease Unit, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Arcaro","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Neurodegenerative Disease Unit, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Arighi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Neurodegenerative Disease Unit, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio Giulio","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Neurodegenerative Disease Unit, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"},{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Neurodegenerative Disease Unit, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio","family":"Scarpini","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Neurodegenerative Disease Unit, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Neurodegenerative Disease Unit, \u201cDino Ferrari\u201d Center, University of Milan, Fondazione C\u00e0 Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150980"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00102"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6694-0"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-017-0073-9"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1221"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70178-3"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1546"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.11.1803"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2004.10.011"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16011385"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110074"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2016.12.005"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.11.5737"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1985.tb07167.x"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.10.019"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2011.08.005"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.06.007"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.2174\/1567205014666170203100734"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-170861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-170861","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-170861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:05:39Z","timestamp":1777370739000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-170861"}},"subtitle":[],"editor":[{"given":"Marco","family":"Bozzali","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,23]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,1,23]]}},"alternative-id":["10.3233\/JAD-170861"],"URL":"https:\/\/doi.org\/10.3233\/jad-170861","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,23]]}}}