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Multiple factors play a role in AD pathology, which includes familial mutations, oxidative stress, and post-translational modifications. Melatonin is an endocrine hormone, secreted during darkness, derived from tryptophan, and produced mainly by the pineal gland. It is an amphipathic molecule, which makes it suitable to cross not only blood-brain barrier, but also to enter several other subcellular compartments like mitochondria and endoplasmic reticulum. In this context, the neuroprotective effect of melatonin may be attributed to its role as an antioxidant. Melatonin\u2019s pleiotropic function as an antioxidant and neuroprotective agent has been widely studied. However, its direct effect on the aggregation of tau and amyloid-\u03b2 needs to be explored. Furthermore, an important aspect of its function is its ability to regulate the process of phosphorylation of tau by affecting the function of kinases and phosphatases. In this review, we are focusing on the pleiotropic function of melatonin on the aspect of its neuroprotective function in tau pathology, which includes antioxidant function, regulation of enzymes, including kinases and enzymes involved in free radical scavenging and mitochondrial protection.<\/jats:p>","DOI":"10.3233\/jad-170900","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T11:37:58Z","timestamp":1521200278000},"page":"1481-1493","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":64,"title":["Multi-Faceted Role of Melatonin in Neuroprotection and Amelioration of Tau Aggregates in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"62","author":[{"given":"Abhishek Ankur","family":"Balmik","sequence":"first","affiliation":[{"name":"Neurobiology Group, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India"},{"name":"Academy of Scientific and 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