{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:16:32Z","timestamp":1779214592350,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,2,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Histopathological studies have confirmed that soft drusen contains amyloid-\u03b2 (A\u03b2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To examine the relationship between the area of soft drusen in the macular area and cerebral A\u03b2 accumulation or plasma A\u03b2 level in elderly persons without dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Fourteen consecutive patients (18 eyes) aged \u226550 years with macular soft drusen were studied prospectively. From color fundus photographs, the area of soft drusen (pixel) within a 6,000 \u03bcm diameter with the macula as center was measured. Standard uptake value ratio (SUVR) was obtained from positron emission tomography using florbetapir, which indicates the ratio of cerebral cortical-to-cerebellar A\u03b2 accumulation. Ratio of plasma A\u03b2\n                      <jats:sub>1-42<\/jats:sub>\n                      to A\u03b2\n                      <jats:sub>1-40<\/jats:sub>\n                      level was calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean age was 73.3\u00b17.6 years. The soft drusen area was 4.32\u00b12.42 mm\n                      <jats:sup>2<\/jats:sup>\n                      . The SUVR was 1.08\u00b10.15. Plasma A\u03b2\n                      <jats:sub>1-42<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>1-40<\/jats:sub>\n                      ratio was 0.17\u00b10.08. When SUVR \u22651.10 was defined as positive and &lt;1.10 as negative, the soft drusen area in SUVR-positive patients (6.19\u00b11.14 mm\n                      <jats:sup>2<\/jats:sup>\n                      ) was significantly ( p\u200a=\u200a0.0043) larger than that in SUVR-negative patients (3.13\u00b12.27 mm\n                      <jats:sup>2<\/jats:sup>\n                      ). Multivariate regression analysis showed that SUVR positivity correlated with soft drusen area ( p\u200a=\u200a0.0484) and with Voxel-based Specific Regional Analysis System for Alzheimer\u2019s Disease score ( p\u200a=\u200a0.0360). However, there was no correlation with gender ( p\u200a=\u200a0.1921), age ( p\u200a=\u200a0.2361), Alzheimer\u2019s Disease Assessment Scale score ( p\u200a=\u200a0.6310), Mini-Mental State Examination score ( p\u200a=\u200a0.4246), or plasma A\u03b2\n                      <jats:sub>1-42<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>1-40<\/jats:sub>\n                      ratio ( p\u200a=\u200a0.8398).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Among elderly persons without dementia, the area of soft drusen was larger in those with more extensive cerebral A\u03b2 accumulation. The area of soft drusen may be a biomarker of cerebral A\u03b2 accumulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-170956","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T13:02:19Z","timestamp":1517922139000},"page":"239-245","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Relationship of Area of Soft Drusen in Retina with Cerebral Amyloid-\u03b2 Accumulation and Blood Amyloid-\u03b2 Level in the Elderly"],"prefix":"10.1177","volume":"62","author":[{"given":"Chiho","family":"Shoda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Nihon University, Chiyoda-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yorihisa","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Nihon University, Chiyoda-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Nihon University, Chiyoda-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuko","family":"Yuzawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Nihon University, Chiyoda-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amane","family":"Tateno","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Nippon Medical School, Bunkyo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Nippon Medical School, Bunkyo-ku, Tokyo, 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