{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:59:18Z","timestamp":1777395558290,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,3,27]]},"abstract":"<jats:p>Cardiovascular disease resulting from oxidative stress and inflammation can exacerbate Alzheimer\u2019s disease. This brief report provides the first evidence of compromised small peripheral mesenteric resistance artery (MRA) properties in 15-month-old 3xTg-AD mice. Females showed worse physiologically relevant MRA structural (increased passive external and internal diameters, cross sectional area) and functional (increased active internal diameters) alterations suggesting sex-dependent dysfunctions. At both physiological and high intraluminal pressures, vascular alterations correlated with the anxious-like behavioral profile, in a sex-dependent manner. Finally, the results unveil a crosstalk between peripheral small vessel properties and behavior in both 3xTg-AD mice and age-matched counterparts with normal aging.<\/jats:p>","DOI":"10.3233\/jad-171019","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T15:51:49Z","timestamp":1520005909000},"page":"1531-1538","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Crosstalk between Peripheral Small Vessel Properties and Anxious-like Profiles: Sex, Genotype, and Interaction Effects in Mice with Normal Aging and 3\u00d7Tg-AD mice at Advanced Stages of Disease"],"prefix":"10.1177","volume":"62","author":[{"given":"Francesc","family":"Jim\u00e9nez-Altay\u00f3","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Therapeutics and Toxicology, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Institut de Neuroci\u00e8ncies, Universitat 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