{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:42:15Z","timestamp":1790811735100,"version":"4.1.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,2,20]]},"abstract":"<jats:p>\n                    Alzheimer\u2019s disease and other dementias present with tau pathology. Several mouse lines with knockout of the tau-encoding Mapt gene have been reported, yet findings often differed between lines and sites. Here, we report a new tau knockout strain (tau\n                    <jats:sup>\u0394ex1<\/jats:sup>\n                    ), generated by CRISPR\/Cas9-mediated genome editing of intron -1\/exon 1 of Mapt in C57Bl\/6J mice. Tau\n                    <jats:sup>\u0394ex1<\/jats:sup>\n                    mice had no overt phenotype, but, in line with previous models, they showed a significantly reduced susceptibility to excitotoxic seizures, with normal memory formation in young mice. This new in vivo resource will be made freely available to the research community.\n                  <\/jats:p>","DOI":"10.3233\/jad-171058","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T18:25:57Z","timestamp":1519151157000},"page":"571-578","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Generation of a New Tau Knockout (tau\n                    <sup>\u0394ex1<\/sup>\n                    ) Line Using CRISPR\/Cas9 Genome Editing in Mice"],"prefix":"10.1177","volume":"62","author":[{"given":"Daniel C.S.","family":"Tan","sequence":"first","affiliation":[{"name":"Dementia Research Unit, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia"},{"name":"Transgenic Animal Unit, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherilyn","family":"Yao","sequence":"additional","affiliation":[{"name":"Transgenic Animal Unit, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Ittner","sequence":"additional","affiliation":[{"name":"Dementia Research Unit, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefine","family":"Bertz","sequence":"additional","affiliation":[{"name":"Dementia Research Unit, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazi D.","family":"Ke","sequence":"additional","affiliation":[{"name":"Motor Neuron Disease Unit, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars M.","family":"Ittner","sequence":"additional","affiliation":[{"name":"Dementia Research Unit, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia"},{"name":"Transgenic Animal Unit, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW, Australia"},{"name":"Neuroscience Research Australia, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Delerue","sequence":"additional","affiliation":[{"name":"Transgenic Animal Unit, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2194"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21867"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084849"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1007\/PL00012495"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00618-0"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah6205"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.036"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90117-V"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(00)00019-9"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199910)46:4<617::AID-ANA10>3.0.CO;2-I"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1038\/78078"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808084105"},{"key":"ref013","first-page":"873270","volume":"2012","author":"Ke 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