{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:59:29Z","timestamp":1777395569576,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T00:00:00Z","timestamp":1521158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,3,27]]},"abstract":"\n Background:<\/jats:title>\n Homozygous APOE \u025b 4 status is a well-known risk factor in the development of Alzheimer\u2019s disease (AD). However, other genotypes of APOE have not yet been found to have equal clinical significance. There is a paucity of reports regarding clinically or pathologically described AD in APOE \u025b 2 homozygotes compared to the other alleles.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To notify clinicians that patients with homozygous APOE \u025b 2 are also at risk of developing AD based on results from the largest prospectively gathered registry of brain samples to date.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We queried the National Alzheimer\u2019s Coordinating Center (NACC) database for autopsy-confirmed AD cases. Of the Uniform Data Set (UDS) participants who are deceased, 5,779 were diagnosed with dementia at their last UDS visit prior to death, and autopsy data is available for 3,518.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Of the brains in the NACC database with pathologically confirmed dementia, seven were found to be homozygous for APOE \u025b 2, which represents only 0.2% of the autopsy-confirmed sample. Furthermore, pathology-confirmed AD represents 29% (2\/7) of the APOE \u025b 2\/ \u025b 2 patients diagnosed with dementia.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Although rare, autopsy-confirmed AD can be present in APOE \u025b 2\/ \u025b 2 carriers.<\/jats:p>\n <\/jats:sec>","DOI":"10.3233\/jad-171060","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T11:38:06Z","timestamp":1521200286000},"page":"1527-1530","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pathologically Confirmed Alzheimer\u2019s Disease in\n \n APOE\n \u025b<\/i>\n 2\n <\/i>\n Homozygotes is Rare but Does Occur"],"prefix":"10.1177","volume":"62","author":[{"given":"Faissal","family":"Stipho","sequence":"first","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan N.","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,16]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13439"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4118"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-0932"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2006-9S340"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00286-9"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00331-C"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.252"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-017-0301-3"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1159\/000320589"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.08.030"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051080"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-171060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-171060","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-171060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:06:08Z","timestamp":1777370768000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-171060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,16]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,3,27]]}},"alternative-id":["10.3233\/JAD-171060"],"URL":"https:\/\/doi.org\/10.3233\/jad-171060","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,16]]}}}