{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:59:24Z","timestamp":1777395564603,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,3,27]]},"abstract":"<jats:p>Alzheimer\u2019s disease (AD) and cerebrovascular disease often coexist. However, it is difficult to determine how chronic cerebral hypoperfusion affects the metabolism of amyloid-\u03b2 peptides (A\u03b2) in a living patient with AD. Thus, we developed an animal model of this condition, using transgenic mice (PS1V97L) and right common carotid artery ligation to create chronic cerebral hypoperfusion. The metabolic processes associated with amyloid-\u03b2 peptide (A\u03b2) were observed and evaluated in this PS1V97L plus hypoperfusion model. Compared with control mice, the model revealed significantly upregulated expression of A\u03b2 (including A\u03b2 oligomers), with decreased \u03b1-secretase activity and expression and increased \u03b2-secretase activity and expression. Furthermore, the model revealed increased mRNA and protein expression of the receptor for advanced glycation end products (RAGE) and decreased mRNA and protein expression of low-density lipoprotein receptor-related protein 1 (LRP-1); both these are A\u03b2 transporters. Moreover, the model revealed decreased activity and expression of neprilysin, which is a peripheral A\u03b2 degrading enzyme. These findings suggest that hypoperfusion may magnify the effect of AD on A\u03b2 metabolism by aggravating its abnormal production, transport, and clearance.<\/jats:p>","DOI":"10.3233\/jad-171094","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T05:24:04Z","timestamp":1522214644000},"page":"1609-1621","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["The Effect of Chronic Cerebral Hypoperfusion on Amyloid-\u03b2 Metabolism in a Transgenic Mouse Model of Alzheimer\u2019s Disease (PS1V97L)"],"prefix":"10.1177","volume":"62","author":[{"given":"Heyun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology, Innovation Center for Neurological Disorders, Xuan Wu Hospital, Capital Medical University, Beijing, P.R. 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