{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:12:37Z","timestamp":1780359157666,"version":"3.54.1"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2018,4,10]]},"abstract":"<jats:p>Gait is emerging as a potential diagnostic tool for cognitive decline. The \u2018Deep and Frequent Phenotyping for Experimental Medicine in Dementia Study\u2019 (D&amp;FP) is a multicenter feasibility study embedded in the United Kingdom Dementia Platform designed to determine participant acceptability and feasibility of extensive and repeated phenotyping to determine the optimal combination of biomarkers to detect disease progression and identify early risk of Alzheimer\u2019s disease (AD). Gait is included as a clinical biomarker. The tools to quantify gait in the clinic and home, and suitability for multi-center application have not been examined. Six centers from the National Institute for Health Research Translational Research Collaboration in Dementia initiative recruited 20 individuals with early onset AD. Participants wore a single wearable (tri-axial accelerometer) and completed both clinic-based and free-living gait assessment. A series of macro (behavioral) and micro (spatiotemporal) characteristics were derived from the resultant data using previously validated algorithms. Results indicate good participant acceptability, and potential for use of body-worn sensors in both the clinic and the home. Recommendations for future studies have been provided. Gait has been demonstrated to be a feasible and suitable measure, and future research should examine its suitability as a biomarker in AD.<\/jats:p>","DOI":"10.3233\/jad-171116","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T05:24:34Z","timestamp":1522214674000},"page":"331-341","source":"Crossref","is-referenced-by-count":56,"title":["Gait in Mild Alzheimer\u2019s Disease: Feasibility of Multi-Center Measurement in the Clinic and Home with Body-Worn Sensors: A Pilot Study1"],"prefix":"10.1177","volume":"63","author":[{"given":"R\u00edona","family":"Mc Ardle","sequence":"first","affiliation":[{"name":"Institute of Neuroscience, Newcastle University, Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Deep and Frequent Phenotyping study team (http:\/\/www.dementiastudy.co.uk)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Morris","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Newcastle University, Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aodh\u00e1n","family":"Hickey","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Newcastle University, Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Del Din","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Newcastle University, Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Koychev","sequence":"additional","affiliation":[{"name":"UK Department of Psychiatry, University of Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger N.","family":"Gunn","sequence":"additional","affiliation":[{"name":"MANOVA Ltd, London, UK"},{"name":"Department of Medicine, Imperial College, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lawson","sequence":"additional","affiliation":[{"name":"UK Department of Psychiatry, University of Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Zamboni","sequence":"additional","affiliation":[{"name":"UK Department of Psychiatry, University of Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil","family":"Ridha","sequence":"additional","affiliation":[{"name":"NIHR Queen Square Dementia Biomedical Research Unit, University College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Sahakian","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Cambridge, UK and MRC Cognition and Brain Sciences Unit, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Thomas","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Newcastle University, Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"},{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"},{"name":"Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK"},{"name":"UK Dementia Research Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"MacKay","sequence":"additional","affiliation":[{"name":"UK Department of Psychiatry, University of Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lovestone","sequence":"additional","affiliation":[{"name":"UK Department of Psychiatry, University of Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Rochester","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Newcastle University, Newcastle, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-171116_ref1","volume-title":"World Alzheimer Report 2015. 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