{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:05:45Z","timestamp":1777395945289,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,6,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Detection of pathological tau aggregates could facilitate clinical diagnosis of Alzheimer\u2019s disease (AD) and monitor drug effects in clinical trials. S-[\n                      <jats:sup>18<\/jats:sup>\n                      F]THK-5117 could be a potential tracer to detect pathological tau deposits in brain. However, no previous study have correlated S-[\n                      <jats:sup>18<\/jats:sup>\n                      F]THK-5117 uptake in PET with brain biopsy verified tau pathology in vivo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      Here we aim to evaluate the association between cerebrospinal fluid (CSF) AD biomarkers, S-[\n                      <jats:sup>18<\/jats:sup>\n                      F]THK-5117, and [\n                      <jats:sup>11<\/jats:sup>\n                      C]PIB PET against tau and amyloid lesions in brain biopsy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Fourteen patients with idiopathic normal pressure hydrocephalus (iNPH) with previous shunt surgery including right frontal cortical brain biopsy and CSF A\u03b2\n                      <jats:sub>1 - 42<\/jats:sub>\n                      , total tau, and P-tau\n                      <jats:sub>181<\/jats:sub>\n                      measures, underwent brain MRI, [\n                      <jats:sup>11<\/jats:sup>\n                      C]PIB PET, and S-[\n                      <jats:sup>18<\/jats:sup>\n                      F]THK-5117 PET imaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Seven patients had amyloid-\u03b2 (A\u03b2, 4G8) plaques, two both A\u03b2 and phosphorylated tau (P \u03c4, AT8) and one only P \u03c4 in biopsy. As expected, increased brain biopsy A\u03b2 was well associated with higher [\n                      <jats:sup>11<\/jats:sup>\n                      C]PIB uptake in PET. However, S-[\n                      <jats:sup>18<\/jats:sup>\n                      F]THK-5117 uptake did not show any statistically significant correlation with either brain biopsy P \u03c4 or CSF P-tau\n                      <jats:sub>181<\/jats:sub>\n                      or total tau.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      S-[\n                      <jats:sup>18<\/jats:sup>\n                      F]THK-5117 lacked clear association with neuropathologically verified tau pathology in brain biopsy probably, at least partially, due to off-target binding. Further studies with larger samples of patients with different tau tracers are urgently needed. The detection of simultaneous A\u03b2 and tau pathology in iNPH is important since that may indicate poorer and especially shorter response for CSF shunt surgery compared with no pathology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-180071","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T12:06:11Z","timestamp":1527854771000},"page":"171-179","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["S-[\n                    <sup>18<\/sup>\n                    F]THK-5117-PET and [\n                    <sup>11<\/sup>\n                    C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-\u03b2 Plaques and Tau in Brain Biopsies"],"prefix":"10.1177","volume":"64","author":[{"given":"Ville","family":"Leinonen","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine \u2013 Neurosurgery, University of Eastern Finland and Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland"},{"name":"Unit of ClinicalNeuroscience, Neurosurgery, University of Oulu and Medical Research Center, Oulu University Hospital, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomas","family":"Rauramaa","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine \u2013 Pathology, University of Eastern Finland andDepartment of Pathology, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarkko","family":"Johansson","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Bottelbergs","sequence":"additional","affiliation":[{"name":"Janssen Research and Development, A Division of Janssen Pharmaceutica, Beerse, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Tesseur","sequence":"additional","affiliation":[{"name":"Janssen Research and Development, A Division of Janssen Pharmaceutica, Beerse, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"van der Ark","sequence":"additional","affiliation":[{"name":"Janssen Research and Development, A Division of Janssen Pharmaceutica, Beerse, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darrel","family":"Pemberton","sequence":"additional","affiliation":[{"name":"Janssen Research and Development, A Division of Janssen Pharmaceutica, Beerse, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Koivisto","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine \u2013 Neurology, Universityof Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha E.","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine \u2013 Neurosurgery, University of Eastern Finland and Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Hiltunen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine \u2013 Neurology, Universityof Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland"},{"name":"Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanna-Kaisa","family":"Herukka","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine \u2013 Neurology, Universityof Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, 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UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka","family":"Jokinen","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"},{"name":"Department of Neurosurgery, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Rokka","sequence":"additional","affiliation":[{"name":"Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of Turku, Turku, Finland"},{"name":"Athinoula A. 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