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We compared brain perfusion SPECT of 18 svPPA patients with cerebrospinal fluid (CSF) biomarkers indicative of non-AD pathology (svPPA-nonAD) and three svPPA patients with CSF biomarkers indicative of underlying AD (svPPA-AD). All svPPA patients had severe left temporopolar hypoperfusion. SvPPA-nonAD had additional anterior cingulate and mediofrontal hypoperfusion, whereas svPPA-AD had greater left parietal and posterior cingulate involvement. Parietal damage in svPPA constitutes a biomarker for underlying Alzheimer pathology thus refining the classification of this PPA variant.<\/jats:p>","DOI":"10.3233\/jad-180087","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T16:24:03Z","timestamp":1537892643000},"page":"271-280","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Parietal Involvement in the Semantic Variant of Primary Progressive Aphasia with Alzheimer\u2019s Disease Cerebrospinal Fluid Profile"],"prefix":"10.1177","volume":"66","author":[{"given":"G\u00e9raldine","family":"Bera","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire, Groupe Hospitalier Piti\u00e9 Salp\u00eatri\u00e8re-Charles Foix, AP-HP, Paris CEDEX 13, France"},{"name":"INSERM U 1127, CNRS UMR 7225, Sorbonne Universit\u00e9s, and Universit\u00e9 Pierre et Marie Curie-Paris 6, UMR S 1127, Institut du 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