{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:01:36Z","timestamp":1778180496114,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2018,5,30]]},"DOI":"10.3233\/jad-180107","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T10:40:13Z","timestamp":1526640013000},"page":"1261-1267","source":"Crossref","is-referenced-by-count":21,"title":["Meta-Analysis of the Association between Variants in ABCA7 and Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"63","author":[{"given":"Fang-Chen","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Weifang Medical University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Fu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi-Peng","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Chen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Tai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"},{"name":"Clinical Research Center, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-180107_ref1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/ng.3916","article-title":"Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer\u2019s disease","volume":"49","author":"Sims","year":"2017","journal-title":"Nat Genet"},{"key":"10.3233\/JAD-180107_ref2","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer\u2019s disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat Genet"},{"key":"10.3233\/JAD-180107_ref3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer\u2019s disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat Genet"},{"key":"10.3233\/JAD-180107_ref4","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer\u2019s disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat Genet"},{"key":"10.3233\/JAD-180107_ref5","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat Genet"},{"key":"10.3233\/JAD-180107_ref6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/1533317516679303","article-title":"Association of GWAS top genes with late-onset Alzheimer\u2019s disease in Colombian population","volume":"32","author":"Moreno","year":"2017","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"10.3233\/JAD-180107_ref7","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.neurobiolaging.2013.09.025","article-title":"Evaluation of late-onset Alzheimer disease genetic susceptibility risks in a Canadian population","volume":"35","author":"Omoumi","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-180107_ref8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s12031-017-0928-7","article-title":"Validating GWAS variants from microglial genes implicated in Alzheimer\u2019s disease","volume":"62","author":"Dos Santos","year":"2017","journal-title":"J Mol Neurosci"},{"key":"10.3233\/JAD-180107_ref9","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jalz.2012.08.007","article-title":"Association of GWAS-linked loci with late-onset Alzheimer\u2019s disease in a northern Han Chinese population","volume":"9","author":"Tan","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-180107_ref10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/WAD.0000000000000000","article-title":"A complex association of ABCA7 genotypes with sporadic Alzheimer disease in Chinese Han population","volume":"28","author":"Liu","year":"2014","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-180107_ref11","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/WAD.0b013e31826d7281","article-title":"Association of GWAS top hits with late-onset Alzheimer disease in Korean population","volume":"27","author":"Chung","year":"2013","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-180107_ref12","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/j.neurobiolaging.2014.05.009","article-title":"ABCA7 gene and the risk of Alzheimer\u2019s disease in Han Chinese in Taiwan","volume":"35","author":"Liao","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-180107_ref13","doi-asserted-by":"crossref","first-page":"e58618","DOI":"10.1371\/journal.pone.0058618","article-title":"SORL1 is genetically associated with late-onset Alzheimer\u2019s disease in Japanese, Koreans and Caucasians","volume":"8","author":"Miyashita","year":"2013","journal-title":"PLoS One"},{"key":"10.3233\/JAD-180107_ref14","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1001\/archneurol.2011.646","article-title":"A comprehensive genetic association study of Alzheimer disease in African Americans","volume":"68","author":"Logue","year":"2011","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-180107_ref15","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1212\/NXG.0000000000000079","article-title":"ABCA7 frameshift deletion associated with Alzheimer disease in African Americans","volume":"2","author":"Cukier","year":"2016","journal-title":"Neurol Genet"},{"key":"10.3233\/JAD-180107_ref16","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1212\/NXG.0000000000000126","article-title":"ABCA7 loss-of-function variants, expression, and neurologic disease risk","volume":"3","author":"Allen","year":"2017","journal-title":"Neurol Genet"},{"key":"10.3233\/JAD-180107_ref17","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1212\/NXG.0000000000000044","article-title":"Overlap between Parkinson disease and Alzheimer disease in ABCA7 functional variants","volume":"2","author":"Nuytemans","year":"2016","journal-title":"Neurol Genet"},{"key":"10.3233\/JAD-180107_ref18","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1212\/WNL.0000000000002627","article-title":"ABCA7 rare variants and Alzheimer disease risk","volume":"86","author":"Le Guennec","year":"2016","journal-title":"Neurology"},{"key":"10.3233\/JAD-180107_ref19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ana.24466","article-title":"Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci","volume":"78","author":"Vardarajan","year":"2015","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-180107_ref20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/ng.3246","article-title":"Loss-of-function variants in ABCA7 confer risk of Alzheimer\u2019s disease","volume":"47","author":"Steinberg","year":"2015","journal-title":"Nat Genet"},{"key":"10.3233\/JAD-180107_ref21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13195-015-0154-x","article-title":"Role of ABCA7 loss-of-function variant in Alzheimer\u2019s disease: A replication study in European-Americans","volume":"7","author":"Del-Aguila","year":"2015","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-180107_ref22","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S1474-4422(15)00133-7","article-title":"Mutations in ABCA7 in a Belgian cohort of Alzheimer\u2019s disease patients: A targeted resequencing study","volume":"14","author":"Cuyvers","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-180107_ref23","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.3233\/JAD-180107_ref24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cct.2015.09.002","article-title":"Meta-analysis in clinical trials revisited","volume":"45","author":"DerSimonian","year":"2015","journal-title":"Contemp Clin Trials"},{"key":"10.3233\/JAD-180107_ref25","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"10.3233\/JAD-180107_ref26","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.3233\/JAD-180107_ref27","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.7150\/jca.19750","article-title":"The clinical effect of metformin on the survival of lung cancer patients with diabetes: A comprehensive systematic review and meta-analysis of retrospective studies","volume":"8","author":"Cao","year":"2017","journal-title":"J Cancer"},{"key":"10.3233\/JAD-180107_ref28","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1212\/WNL.0000000000000335","article-title":"Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD","volume":"82","author":"Carrasquillo","year":"2014","journal-title":"Neurology"},{"key":"10.3233\/JAD-180107_ref29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neurobiolaging.2016.04.004","article-title":"ABCA7 p.G215S as potential protective factor for Alzheimer\u2019s disease","volume":"46","author":"Sassi","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-180107_ref30","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.ajhg.2009.10.015","article-title":"Genomic dissection of population substructure of Han Chinese and its implication in association studies","volume":"85","author":"Xu","year":"2009","journal-title":"Am J Hum Genet"},{"key":"10.3233\/JAD-180107_ref31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.12659\/MSM.895622","article-title":"Associations between genetic variants in 19p13 and 19q13 regions and susceptibility to Alzheimer disease: A meta-analysis","volume":"22","author":"Bao","year":"2016","journal-title":"Med Sci Monit"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-180107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:06Z","timestamp":1777370826000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-180107"}},"subtitle":[],"editor":[{"given":"Ling-Qiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,5,30]]},"references-count":31,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/jad-180107","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,30]]}}}