{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:32:07Z","timestamp":1784752327516,"version":"3.55.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T00:00:00Z","timestamp":1527465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,6,8]]},"abstract":"<jats:p>\n                    We performed a meta-analysis to determine whether combination therapy with serotonin reuptake inhibitors (SRIs) and memantine (MEM) was beneficial for the treatment of obsessive\u2013 compulsive disorder. This study included three double-blind, randomized, placebo-controlled trials. MEM+SRI was superior to placebo+SRI with regard to response rate [primary outcome, n = 97; risk ratio = 0.22; 95% confidence intervals (CI) = 0.12\u20130.42; p &lt; 0.00001; I\n                    <jats:sup>2<\/jats:sup>\n                    = 0%; number needed to treat = 2], the Yale\u2013 Brown Obsessive\u2013 Compulsive Scale total [standardized mean difference (SMD) = \u2013 4.56; 95% CI = \u2013 8.50, \u2013 0.62; p = 0.02], obsession subscale (SMD = \u2013 4.39; 95% CI = \u2013 5.94, \u2013 2.85; p &lt; 0.00001), and compulsion subscale score (SMD = \u2013 4.60; 95% CI = \u2013 7.64, \u2013 1.55; p = 0.003). No significant differences in any safety outcome were found between the groups.\n                  <\/jats:p>","DOI":"10.3233\/jad-180237","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T11:23:07Z","timestamp":1527592987000},"page":"43-48","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Combination Therapy of Serotonin Reuptake Inhibitors and Memantine for Obsessive\u2013 Compulsive Disorder: A Meta-Analysis of Double-Blind, Randomized, Placebo-Controlled Trials"],"prefix":"10.1177","volume":"64","author":[{"given":"Taro","family":"Kishi","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Fujita Health University School of Medicine, Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Fujita Health University School of Medicine, Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan"},{"name":"Department of Psychiatry, Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakao","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Fujita Health University School of Medicine, Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,5,28]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60240-3"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2200"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30069-4"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00443-5"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.2147\/PRBM.S58601"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.150"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15l10138"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666160321123221"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1002\/gps.938"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.2165\/11634390-000000000-00000"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7021071"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2506-07.2007"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4616-7"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S142839"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161251"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170424"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-120268"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3067-z"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.09.015"},{"key":"ref020","unstructured":"HigginsJ, GreenS (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0, The Cochrane Collaboration, http:\/\/www.cochrane-handbook.org."},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110054008"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-9-2"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16080868"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-180237","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:12Z","timestamp":1777370832000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-180237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,28]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,6,8]]}},"alternative-id":["10.3233\/JAD-180237"],"URL":"https:\/\/doi.org\/10.3233\/jad-180237","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,28]]}}}