{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:58:05Z","timestamp":1793321885810,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,7,24]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cerebral amyloid angiopathy (CAA) can be associated with primary vasculitis of small\/medium-sized leptomeningeal and cortical arteries, called CAA-related inflammation (CAA-ri).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare hemorrhagic and diffusion-weighted imaging (DWI) MRI features in CAA and CAA-ri.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We prospectively scored in a consecutive CAA and CAA-ri cohort: presence\/number of chronic intracerebral hemorrhage (ICH), cerebral microbleeds (CMB), and cortical superficial siderosis (CSS) on initial T2*-weighted imaging, and DWI lesions on both initial and follow-up imaging. In a subgroup, ApoE, CSF, and 18F-florbetaben-positron emission tomography (FBB-PET) were also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In CAA-ri, CMB presence was more frequent (100% versus 40%, p &lt; 0.001) and CMB numbers higher (mean 137 versus 8, p &lt; 0.001). No difference was observed for chronic ICH or CSS. DWI lesions were more frequent in acute compared to chronic CAA-ri ( p = 0.025), whereas no such difference was observed between acute and chronic CAA ( p = 0.18). Both ApoE4 (genotyping available in 22 CAA-ri and 48 CAA patients) carriers and homozygosity were more frequent in CAA-ri (48% versus 19% [ p = 0.014] and 32% versus 2% [ p &lt; 0.001] respectively). CSF biomarker analyses (performed in 20 CAA-ri and 45 CAA patients) showed lower A \u03b2\n                      <jats:sub>42<\/jats:sub>\n                      levels in CAA-ri compared to CAA (median 312 versus 422 pg\/mL, p = 0.0032). FBB-PET (performed in 11 CAA-ri and 20 CAA patients) showed higher standardized uptake value ratios in CAA-ri compared with CAA, only significant when the pons was used as reference ( p = 0.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Compared to CAA, CAA-ri was associated with higher CMB numbers, more frequent ApoE4 carriers and homozygotes, lower CSF A \u03b2\n                      <jats:sub>42<\/jats:sub>\n                      levels, and more severe amyloid load on FBB-PET.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-180269","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T13:40:03Z","timestamp":1531489203000},"page":"1113-1121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Cerebral Amyloid Angiopathy and Cerebral Amyloid Angiopathy-Related Inflammation: Comparison of Hemorrhagic and DWI MRI Features"],"prefix":"10.1177","volume":"64","author":[{"given":"Dimitri","family":"Renard","sequence":"first","affiliation":[{"name":"Department of Neurology, N\u00eemes University Hospital, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Tatu","sequence":"additional","affiliation":[{"name":"Department of Neurology, N\u00eemes University Hospital, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Collombier","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, N\u00eemes University Hospital, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Wacongne","sequence":"additional","affiliation":[{"name":"Department of Neurology, N\u00eemes University Hospital, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Ayrignac","sequence":"additional","affiliation":[{"name":"Department of Neurology, Montpellier University Hospital, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Charif","sequence":"additional","affiliation":[{"name":"Department of Neurology, Montpellier University Hospital, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassine","family":"Boukriche","sequence":"additional","affiliation":[{"name":"Department of Neurology, CH Beziers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Chiper","sequence":"additional","affiliation":[{"name":"Department of Neurology, CH Beziers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Fourcade","sequence":"additional","affiliation":[{"name":"Department of Neurology, CH Narbonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souhayla","family":"Azakri","sequence":"additional","affiliation":[{"name":"Department of Neurology, Montpellier University Hospital, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Gaillard","sequence":"additional","affiliation":[{"name":"Department of Neurology, CH Perpignan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Mercier","sequence":"additional","affiliation":[{"name":"Department of Hematology, N\u00eemes University Hospital, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie-Prot\u00e9omique Clinique \u2013 IRMB \u2013 CRB - Inserm U11183, CHU Montpellier, H\u00f4pital St-Eloi - Universit\u00e9 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Thouvenot","sequence":"additional","affiliation":[{"name":"Department of Neurology, N\u00eemes University Hospital, N\u00eemes, France"},{"name":"Institut de G\u00e9nomique Fonctionnelle, UMR5203, Universit\u00e9 Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,7,12]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh379"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.204180"},{"key":"ref003","first-page":"773","volume":"69","author":"Melzer N","year":"2014","journal-title":"Arch Neurol"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a9f545"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.02.001"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1002\/art.11049"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303898"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.25"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380219"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22134"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000308819.43401.87"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.08.008"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001398"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1159\/000442299"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.09.012"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151036"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260066.98681.2e"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10810"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150621"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23857"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170843"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017741569"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004668"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318278b66f"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr172"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000345666.83318.03"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004228"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21164"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cef7e3"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12188"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001288"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003197"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150614"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150070"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6520-8"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.537"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dad605"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.4078"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70013-4"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.06.008"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-180269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:30Z","timestamp":1777370850000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-180269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,12]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7,24]]}},"alternative-id":["10.3233\/JAD-180269"],"URL":"https:\/\/doi.org\/10.3233\/jad-180269","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,12]]}}}