{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:55:22Z","timestamp":1791618922672,"version":"4.3.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,7,24]]},"abstract":"<jats:p>Depression is one of the most frequent psychiatric symptoms observed in people during the development of Alzheimer\u2019s disease (AD). We hypothesized that genetic factors conferring risk of depression might affect AD development. In this study, we screened 31 genes, which were located in 19 risk loci for major depressive disorder (MDD) identified by two recent large genome-wide association studies (GWAS), in AD patients at the genomic and transcriptomic levels. Association analysis of common variants was performed by using summary statistics of the International Genomics of Alzheimer\u2019s Project (IGAP), and association analysis of rare variants was conducted by sequencing the entire coding region of the 31 MDD risk genes in 107 Han Chinese patients with early-onset and\/or familial AD. We also quantified the mRNA expression alterations of these MDD risk genes in brain tissues of AD patients and AD mouse models, followed by protein-protein interaction network prediction to show their potential effects in AD pathways. We found that common and rare variants of L3MBTL2 were significantly associated with AD. mRNA expression levels of 18 MDD risk genes, in particular SORCS3 and OAT, were differentially expressed in AD brain tissues. 13 MDD risk genes were predicted to physically interact with core AD genes. The involvement of HACE1, NEGR1, and SLC6A15 in AD was supported by convergent lines of evidence. Taken together, our results showed that MDD risk genes might play an active role in AD pathology and supported the notion that depression might be the \u201ccommon cold\u201d of psychiatry.<\/jats:p>","DOI":"10.3233\/jad-180276","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T13:40:24Z","timestamp":1531489224000},"page":"1149-1161","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"64","author":[{"given":"Hua","family":"Ni","sequence":"first","affiliation":[{"name":"Center for Disease Control and Prevention, Shanghai Xuhui Mental Health Center, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China"},{"name":"Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Lai","family":"Zhan","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention, Shanghai Xuhui Mental Health Center, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hejiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Hong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Tan","sequence":"additional","affiliation":[{"name":"Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng-Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Gang","family":"Yao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China"},{"name":"Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China"},{"name":"CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China"},{"name":"KIZ\/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,7,12]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.001"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.02.003"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.12.1475"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00543-2"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61446-9"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3095"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04181"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e318235b611"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1159\/000085859"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199507000-00006"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.3.364"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.6.744"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)00097-3"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.10.1552"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.2.168"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.115.163790"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.232"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3623"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2802"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.21"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.131"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.124"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1038\/nature14659"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.06.009"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2014.79"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi1110s43"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq603"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.03.006"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1038\/nature19057"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.08.012"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.12.041"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.037"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.2000.4.1.83"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.107"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4587"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.0004"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e62138"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.49"},{"key":"ref042","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802679105"},{"key":"ref043","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3736"},{"key":"ref044","doi-asserted-by":"publisher","DOI":"10.1038\/nature13595"},{"key":"ref045","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2006.03.009"},{"key":"ref046","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90385-7"},{"key":"ref047","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075006"},{"key":"ref048","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22308"},{"key":"ref049","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.16"},{"key":"ref050","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.86"},{"key":"ref051","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200008000-00003"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-180276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:07:30Z","timestamp":1777370850000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-180276"}},"subtitle":[],"editor":[{"given":"Yan-Jiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,12]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7,24]]}},"alternative-id":["10.3233\/JAD-180276"],"URL":"https:\/\/doi.org\/10.3233\/jad-180276","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,12]]}}}