{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:20:36Z","timestamp":1777396836671,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2019,4,23]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Despite the well-documented relationship between lobar cerebral microbleeds (lCMB) and Alzheimer\u2019s disease (AD), there is limited knowledge about the role of lCMB in AD pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To understand the nature of this relationship, we investigated the association between lCMB, amyloid load, perfusion, and metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Participants with AD, mild cognitive impairment (MCI), and healthy controls were recruited and scanned with\n                      <jats:sup>11<\/jats:sup>\n                      C-Pittsburg-Compound B (PiB), Fluorodeoxyglucose (FDG) PET, and susceptibility-weighted MRI. Early PiB-PET frames were used to estimate perfusion. The association between lCMB and PET uptake in each anatomical lobe was measured using multiple regression models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The presence of lCMB predicted increased total ( p\u200a&lt;\u200a0.001) and regional ( p\u200a=\u200a0.0002) PiB uptake, as well as decreased cerebral perfusion ( p\u200a=\u200a0.03). Cases with lCMB had hypometabolism in their temporal lobe ( p\u200a=\u200a0.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There are significant relationships between lCMBs and various markers of AD pathology. lCMB has a spatial association with A\u03b2 load and a complex effect on perfusion and metabolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-180443","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T17:19:53Z","timestamp":1553015993000},"page":"1489-1497","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Correlation of Lobar Cerebral Microbleeds with Amyloid, Perfusion, and Metabolism in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"68","author":[{"given":"Nasim","family":"Sheikh-Bahaei","sequence":"first","affiliation":[{"name":"Department of Radiology, Keck School of Medicine of USC, University of Southern California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roido","family":"Manavaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Cambridge School of Clinical Medicine, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Ahmad","family":"Sajjadi","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew N.","family":"Priest","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cambridge University Hospitals, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan H.","family":"Gillard","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Cambridge School of Clinical Medicine, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.07.755"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000505"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.595082"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.12.006"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12472"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70015-7"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1007\/s007020200068"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21164"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cef7e3"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1177\/1971400916689483"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4351"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170470"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.168732"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.05.001"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.082057"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.057612"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1109\/23.34585"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.025"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.11.034"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139926"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.048"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c34a7d"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.3.431"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn016"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm191"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22099"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318221ad36"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1038\/srep44715"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.2174\/1874440000802010114"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.11.006"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.062315"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3734"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2503080751"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S58879"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-120292"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.01.012"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141467"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.09.011"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.11.004"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb48478.x"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150274"},{"key":"ref042","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0834-y"},{"key":"ref043","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2008.00133.x"},{"key":"ref044","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23830"},{"key":"ref045","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3669-09.2009"},{"key":"ref046","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.4.1140"},{"key":"ref047","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-091699"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-180443","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:23Z","timestamp":1777370963000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-180443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,18]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4,23]]}},"alternative-id":["10.3233\/JAD-180443"],"URL":"https:\/\/doi.org\/10.3233\/jad-180443","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,18]]}}}