{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:37:01Z","timestamp":1789994221468,"version":"4.0.1"},"reference-count":58,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,9,25]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Statins have been proposed to reduce the risk of Alzheimer\u2019s disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Assess whether long-term statin use was associated with neuroimaging biomarkers of aging and dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Methods: We analyzed neuroimaging biomarkers in 1,160 individuals aged 65+ from the Mayo Clinic Study of Aging, a population-based prospective longitudinal study of cognitive aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Statin-treated (5+ years of therapy) individuals had greater burden of mid-and late-life cardiovascular disease ( p\u200a&lt;\u200a0.001) than statin-untreated (\u22643 months) individuals. Lower fractional anisotropy in the genu of the corpus callosum, an early marker of cerebrovascular disease, was associated with long-term statin exposure ( p\u200a&lt;\u200a0.035). No significant associations were identified between long-term statin exposure and cerebral amyloid or tau burden, AD pattern neurodegeneration, or white matter hyperintensity burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Long-term statin therapy was not associated with differences in AD biomarkers. Individuals with long-term statin exposure had worse white matter integrity in the genu of the corpus callosum, consistent with the coexistence of higher cerebrovascular risk factor burden in this group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-180446","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T13:55:36Z","timestamp":1535118936000},"page":"1345-1352","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Statins and Brain Health: Alzheimer\u2019s Disease and Cerebrovascular Disease Biomarkers in Older Adults"],"prefix":"10.1177","volume":"65","author":[{"given":"Vijay K.","family":"Ramanan","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic-Rochester, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Przybelski","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic-Rochester, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Graff-Radford","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic-Rochester, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic-Rochester, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic-Rochester, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic-Rochester, Rochester, MN, USA"},{"name":"Department of Health Sciences Research, Mayo Clinic-Rochester, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosebud O.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic-Rochester, Rochester, MN, USA"},{"name":"Department of Health Sciences Research, Mayo Clinic-Rochester, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert I.","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Information Technology, Mayo Clinic-Rochester, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Knopman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic-Rochester, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic-Rochester, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic-Rochester, Rochester, MN, USA"},{"name":"Department of Health Sciences Research, Mayo Clinic-Rochester, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanthi","family":"Vemuri","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic-Rochester, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,8,22]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3505"},{"key":"ref002","first-page":"145","volume":"2","author":"Ramanan VK","year":"2013","journal-title":"Am J Neurodegener Dis"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1007\/s40142-014-0034-x"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32499"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00071"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.35"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003160.pub3"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000277657.95487.1c"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000288181.00826.63"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.11.003"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.02.007"},{"key":"ref012","unstructured":"United States Food and Drug Administration, FDA Drug Safety Communication: Important safety label changes to cholesterol-lowering statin drugs, https:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm293101.htm"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000182897.18229.ec"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-10-201311190-00007"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.07.013"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.2092"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002923"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30077-7"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25071"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu393"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000550"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.1482"},{"key":"ref024","first-page":"1039","volume":"70","author":"Haight TJ","year":"2013","journal-title":"Dissociable effects of Alzheimer disease and white matter hyperintensities on brain metabolism. JAMA Neurol"},{"key":"ref025","first-page":"255","volume":"7","author":"Pelletier A","year":"2015","journal-title":"Front Aging Neurosci"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1159\/000115751"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f11d85"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.08.012"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys195"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004818"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)43176-1"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000269"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.08.005"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004913"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182840c9f"},{"key":"ref036","first-page":"65","volume":"94","author":"Schwarz CG","year":"2014","journal-title":"Improved DTI registration allows voxel-based analysis that outperforms tract-based spatial statistics. Neuroimage"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170146"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.08.016"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3012"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0422"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081612998"},{"key":"ref042","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-008-0012-2"},{"key":"ref043","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.263"},{"key":"ref044","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"ref045","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2009.035"},{"key":"ref046","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5390"},{"key":"ref047","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000160114.42643.31"},{"key":"ref048","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.150433"},{"key":"ref049","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-014-3115-3"},{"key":"ref050","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22361"},{"key":"ref051","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0237-y"},{"key":"ref052","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.3783"},{"key":"ref053","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03155-X"},{"key":"ref054","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-101179"},{"key":"ref055","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2016.09.002"},{"key":"ref056","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.03.05"},{"key":"ref057","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X"},{"key":"ref058","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32835a30f4"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-180446","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:00Z","timestamp":1777370880000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-180446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,22]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,9,25]]}},"alternative-id":["10.3233\/JAD-180446"],"URL":"https:\/\/doi.org\/10.3233\/jad-180446","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,22]]}}}