{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:16:59Z","timestamp":1789078619549,"version":"build-2803163510"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,11,23]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Current research diagnostic criteria for Alzheimer\u2019s disease (AD) and mild cognitive impairment (MCI) due to AD include biomarkers to supplement clinical testing. Recently, we demonstrated that dual time-point [\n                      <jats:sup>18<\/jats:sup>\n                      F]FBB PET is able to deliver both blood flow and amyloid-\u03b2 (A\u03b2) load surrogates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to investigate whether these surrogates can be utilized as AD biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      112 subjects (41 with MCI, 50 with probable\/possible AD, 21 with other dementias) underwent dual time-point [\n                      <jats:sup>18<\/jats:sup>\n                      F]FBB PET. Data were visually and relative quantitatively (Herholz scores for the early and composite SUVRs for the late PET data) analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In the early images AD-typical patterns were present in 42% \/27% \/33% of probable\/possible AD\/MCI\/other dementia cases. In late [\n                      <jats:sup>18<\/jats:sup>\n                      F]FBB PET, 42% \/29% \/38% of probable\/possible AD\/ MCI\/other dementia cases were A\u03b2-positive. 17% of the MCIs were categorized as \u201cMCI due to AD-high likelihood\u201d, 44% of the probable ADs as \u201cprobable AD with high evidence of AD pathophysiological process\u201d and 28% of the possible ADs as \u201cpossible AD with evidence of AD pathophysiological process\u201d. 27% of all subjects showed a positive diagnostic and progression biomarker. Herholz scores were lower (0.85\u00b10.05 versus 0.88\u00b10.04, p\u200a=\u200a0.015) for probable\/possible AD versus MCI. Composite late phase SUVRs were significantly higher (1.65\u00b10.23 versus 1.15\u00b10.17, p\u200a&lt;\u200a0.005) in A\u03b2-positive versus A\u03b2-negative patients. Herholz and MMSE scores were positively correlated (R\u200a=\u200a0.30 p\u200a=\u200a0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Dual time-point [\n                      <jats:sup>18<\/jats:sup>\n                      F]FBB PET provides dual biomarker information which enables to categorize MCI and AD dementia patients according to established diagnostic criteria. Thus, dual time-point [\n                      <jats:sup>18<\/jats:sup>\n                      F]FBB PET has great potential to supplement diagnostic dementia workups.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-180522","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T12:15:17Z","timestamp":1541160917000},"page":"1105-1116","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Dual Time-Point [\n                    <sup>18<\/sup>\n                    F]Florbetaben PET Delivers Dual Biomarker Information in Mild Cognitive Impairment and Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"66","author":[{"given":"Lisa","family":"Florek","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Leipzig University Hospital, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solveig","family":"Tiepolt","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Leipzig University Hospital, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias L.","family":"Schroeter","sequence":"additional","affiliation":[{"name":"Day Clinic for Cognitive Neurology, Leipzig University Hospital & Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Berrouschot","sequence":"additional","affiliation":[{"name":"Department of Neurology, Altenburg Hospital, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Saur","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leipzig University Hospital, Leipzig, 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