{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:22:15Z","timestamp":1789917735216,"version":"4.0.1"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T00:00:00Z","timestamp":1535068800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,9,25]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Elevated total tau (tTau), 181-phosphorylated phosphorylated tau (pTau), and low amyloid-\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      (A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      ) in cerebrospinal fluid (CSF) represent a diagnostic biomarker for Alzheimer\u2019s disease (AD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      The goal was to determine the overall accuracy of CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      , tTau, pTau, and the A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \/total tau index (ATI) in a non-research, clinical setting for the diagnosis of AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      From medical records in 1,016 patients that had CSF studies for dementia over a 12-year period (2005 to 2017), we calculated the sensitivity and specificity of CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      , tTau, and pTau and the ATI in relation to the final clinical diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Compared with non-demented patients and patients with other dementias or mild cognitive impairment (MCI), the sensitivity and specificity of the recommended ATI and pTau cut-offs (ATI\u200a&lt;\u200a1.0 and pTau\u200a&gt;61 pg\/ml) for the diagnosis of AD were 0.88 and 0.72, respectively. Similar results were obtained comparing AD with non-demented patients only (0.88, 0.82) and AD with other types of dementia (0.81, 0.77). A subgroup of patients with presumed normal pressure hydrocephalus ( n\u200a=\u200a154) were biopsied at the time of shunt placement. Using the pathological manifestations of AD as the standard, the sensitivity was 0.83 while the specificity was 0.72.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In a non-research setting, CSF biomarkers for AD showed a high sensitivity in accordance with previous studies, but modest specificity differentiating AD from other types of dementia or MCI. This study of unselected patients provides a valid and realistic assessment of the diagnostic accuracy of these CSF biomarkers in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-180548","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T13:56:08Z","timestamp":1535118968000},"page":"1417-1425","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Clinical Experience with Cerebrospinal Fluid A\u03b2\n                    <sub>42<\/sub>\n                    , Total and Phosphorylated Tau in the Evaluation of 1,016 Individuals for Suspected Dementia"],"prefix":"10.1177","volume":"65","author":[{"given":"Leonardo","family":"Tariciotti","sequence":"first","affiliation":[{"name":"University of Rome \u201cLa Sapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Casadei","sequence":"additional","affiliation":[{"name":"Hamilton College, Clinton, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Honig","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA"},{"name":"Department of Neurology, College of Physicians and Surgeons of Columbia University and The New York Presbyterian Hospital, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F.","family":"Teich","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA"},{"name":"Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy M.","family":"McKhann II","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, College of Physicians and Surgeons of Columbia University and The New York Presbyterian Hospital, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tosto","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA"},{"name":"The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA"},{"name":"Department of Neurology, College of Physicians and Surgeons of Columbia University and The New York Presbyterian Hospital, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mayeux","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA"},{"name":"The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA"},{"name":"Department of Neurology, College of Physicians and Surgeons of Columbia University and The New York Presbyterian Hospital, New York, NY, USA"},{"name":"Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,8,24]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000046581.81650.D0"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.596"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20730"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.064360"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.81"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000242732.06714.0f"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30223-5"},{"key":"ref008","first-page":"CD010803","volume":"3","author":"Ritchie C","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1546"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000224698.67660.45"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.2.250"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10570"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.1"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp191"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.007"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6030-0"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/47.10.1776"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.08.011"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70355-6"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.155"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821ccc98"},{"key":"ref023","unstructured":"IBM Corp. Released (2016) IBM SPSS Statistics for Windows, Version 24.0. 2016."},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00289"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21610"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.02.016"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.12.006"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21610"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131085"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-101878"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.03.003"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03589-3"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0681-2"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000271090.28148.24"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70139-5"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2012.12.012"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2009.12.005"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.50.859"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2009.02.017"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180548","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-180548","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:02Z","timestamp":1777370882000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-180548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,24]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,9,25]]}},"alternative-id":["10.3233\/JAD-180548"],"URL":"https:\/\/doi.org\/10.3233\/jad-180548","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,24]]}}}