{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:01:22Z","timestamp":1791907282090,"version":"4.3.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,10,16]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Idiopathic normal pressure hydrocephalus (iNPH) is commonly treated by cerebrospinal fluid (CSF) shunting. However, the long-term efficacy of shunt intervention in the presence of comorbid Alzheimer\u2019s disease (AD) pathology is debated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To identify AD-associated CSF biomarkers predictive of shunting surgery outcomes in patients with iNPH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Preoperative levels of total and phosphorylated Tau (p-Tau) were measured in 40 patients with iNPH divided into low (&lt;30 pg\/mL) and high (\u226530 pg\/mL) p-Tau groups and followed up for three years after lumboperitoneal shunting. The modified Rankin Scale (mRS), Mini-Mental State Examination (MMSE), Frontal Assessment Battery, and iNPH Grading Scale scores were compared between the age-adjusted low (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u200a=\u200a24; mean age 75.7 years [SD 5.3]) and high (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u200a=\u200a11; mean age 76.0 years [SD 5.6]) p-Tau groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Cognitive function improved early in the low p-Tau group and was maintained thereafter (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.005). In contrast, the high p-Tau group showed a gradual decline to baseline levels by the third postoperative year (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.040). Although the p-Tau concentration did not correlate with the preoperative MMSE score, a negative correlation appeared and strengthened during follow-up (R\n                      <jats:sup>2<\/jats:sup>\n                      \u200a=\u200a0.352,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a&lt;\u200a0.001). Furthermore, the low p-Tau group showed rapid and sustained mRS grade improvement, whereas mRS performance gradually declined in the high p-Tau group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Preoperative CSF p-Tau concentration predicted some aspects of cognitive function after shunt intervention in patients with iNPH. The therapeutic effects of shunt treatment were shorter-lasting in patients with coexisting AD pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-180557","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T13:46:54Z","timestamp":1537537614000},"page":"319-331","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["Preoperative Phosphorylated Tau Concentration in the Cerebrospinal Fluid Can Predict Cognitive Function Three Years after Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus"],"prefix":"10.1177","volume":"66","author":[{"given":"Madoka","family":"Nakajima","sequence":"first","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Ogino","sequence":"additional","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Akiba","sequence":"additional","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaito","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Kamohara","sequence":"additional","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Fusegi","sequence":"additional","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Harada","sequence":"additional","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Hara","sequence":"additional","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Sugano","sequence":"additional","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Tange","sequence":"additional","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostadin","family":"Karagiozov","sequence":"additional","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensaku","family":"Kasuga","sequence":"additional","affiliation":[{"name":"Niigata University","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Niigata University","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Tokuda","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Arai","sequence":"additional","affiliation":[{"name":"Juntendo University Faculty of Medicine","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(65)90016-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.48.S1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.52.775"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8454-7-18"},{"key":"e_1_3_2_6_2","first-page":"1277","article-title":"CSF spaces in idiopathic normal pressure hydrocephalus: Morphology and volumetry","volume":"19","author":"Kitagaki H","year":"1998","unstructured":"KitagakiH, MoriE, IshiiK, YamajiS, HironoN, ImamuraT (1998) CSF spaces in idiopathic normal pressure hydrocephalus: Morphology and volumetry. AJNR Am J Neuroradiol 19, 1277\u20131284.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00046-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25053"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25097"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25046"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0808-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.03.009"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.6.778"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1406"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-9-7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091974"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828c2fda"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119973"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.07.001"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-142622"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180059"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.179"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181af79e5"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00530-1"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl269"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22015"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790060110016"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000111149"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opy044"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2014.08.004"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.039347"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.051201"},{"key":"e_1_3_2_35_2","first-page":"473","article-title":"How attractive does a new technology have to be to warrant adoption and utilization? Tentative guidelines for using clinical and economic evaluations","volume":"146","author":"Laupacis A","year":"1992","unstructured":"LaupacisA, FeenyD, DetskyAS, TugwellPX (1992) How attractive does a new technology have to be to warrant adoption and utilization? Tentative guidelines for using clinical and economic evaluations. CMAJ 146, 473\u2013481.","journal-title":"CMAJ"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-017-3115-2"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/20.6.649"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1159\/000328625"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-018-1842-z"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-14-66"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03781.x"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-011-0963-z"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0390-5616.18.04350-3"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.095117"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22100"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.008"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24517"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000916"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-10-22"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20112"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21710"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-180557","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:10Z","timestamp":1777370890000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-180557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,21]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,10,16]]}},"alternative-id":["10.3233\/JAD-180557"],"URL":"https:\/\/doi.org\/10.3233\/jad-180557","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,21]]}}}