{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:23:34Z","timestamp":1790400214319,"version":"4.1.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,11,23]]},"abstract":"<jats:p>\n                    Differentially methylated positions (DMPs) between persons with and without late-onset Alzheimer\u2019s disease (LOAD) were observed at 477 of 769,190 loci in a plurality of genes. Of these, 17 were shared with DMPs identified using clinical LOAD markers analyzed independently as continuous variables comprising Rey Auditory Verbal Learning Test scores, cerebrospinal fluid total tau (t-tau) and phosphorylated tau 181 (p-tau\n                    <jats:sub>181<\/jats:sub>\n                    ) levels, and t-tau\/A\u03b21\u201342 (A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    ), p-tau\n                    <jats:sub>181<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    , and A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    \/A\u03b21\u201340 (A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    ) ratios. In patients with LOAD, 12 of the shared 17 DMPs were hypomethylated in B3GALT4 (Beta-1,3-galatcosyltransferase 4) (EC 2.4.1.62), and 5 were hypomethylated in ZADH2 (Prostaglandin reductase 3) (EC 1.3.1.48).\n                  <\/jats:p>","DOI":"10.3233\/jad-180592","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T17:45:30Z","timestamp":1540316730000},"page":"927-934","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":65,"title":["DNA Hypomethylation in Blood Links\n                    <i>B3GALT4<\/i>\n                    and\n                    <i>ZADH2<\/i>\n                    to Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"66","author":[{"given":"Andy","family":"Madrid","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI,\r            USA"},{"name":"Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI,\r            USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk J.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI,\r            USA"},{"name":"Wisconsin Alzheimer\u2019s Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI,\r            USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia A.","family":"Papale","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI,\r            USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay R.","family":"Clark","sequence":"additional","affiliation":[{"name":"Wisconsin Alzheimer\u2019s Institute, University of Wisconsin School of Medicine and Public 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