{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:39:55Z","timestamp":1790343595046,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2019,2,19]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Idiopathic normal pressure hydrocephalus (iNPH) is frequently associated with concomitant amyloid-\u03b2 (A\u03b2) pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To compare the [\n                      <jats:sup>11<\/jats:sup>\n                      C]PIB PET uptake in the patients with suspected iNPH to A\u03b2 and hyperphosphorylated-tau (HP \u03c4) in the right frontal cortical biopsy, the cerebrospinal fluid (CSF) A\u03b2, the response to a CSF shunt, and the final clinical diagnosis of Alzheimer\u2019s disease (AD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Patients ( n\u200a=\u200a21) from Kuopio NPH Registry ( http:\/\/www.uef.fi\/nph ) with intraventricular pressure monitoring, immunostaining for A\u03b2 and HP \u03c4 in the right frontal cortical biopsies, and a Mini-Mental State Examination and a Clinical Dementia Rating underwent [\n                      <jats:sup>11<\/jats:sup>\n                      C]PIB PET. A\u03b2, total tau, and P \u03c4\n                      <jats:sub>181<\/jats:sub>\n                      were measured by ELISA from the ventricular ( n\u200a=\u200a15) and the lumbar ( n\u200a=\u200a9) CSF. Response to the shunt was seen in 13 out of the 15 shunted patients. AD was diagnosed in 8\u00a0patients during a median follow-up of 6 years (mean 7.3\u00b12.4 years, range 3\u20131).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>11<\/jats:sup>\n                      C]PIB uptake in the right frontal cortex ( \u03c1=\u200a0.60, p\u200a&lt;\u200a0.01) and the combined neocortical [\n                      <jats:sup>11<\/jats:sup>\n                      C]PIB uptake score ( \u03c1=\u200a0.61, p\u200a&lt;\u200a0.01) were associated with a higher A\u03b2 load in the right frontal cortical biopsy. Excluding one (1\/15) outlier, [\n                      <jats:sup>11<\/jats:sup>\n                      C]PIB uptake was also associated with the ventricular CSF A\u03b2 ( \u03c1=\u200a\u20130.58, p\u200a=\u200a0.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The findings show that [\n                      <jats:sup>11<\/jats:sup>\n                      C]PIB PET can reliably detect simultaneous amyloid pathology among the iNPH patients. Further studies will show whether amyloid PET could predict a clinical response to the shunt operation. In addition, the presence of A\u03b2 pathology in the patients with iNPH might also warrant treatment with current AD drugs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-180645","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T21:02:05Z","timestamp":1548190925000},"page":"1343-1351","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["[\n                    <sup>11<\/sup>\n                    C]PIB PET Is Associated with the Brain Biopsy Amyloid-\u03b2 Load in Subjects Examined for Normal Pressure Hydrocephalus"],"prefix":"10.1177","volume":"67","author":[{"given":"Juha O.","family":"Rinne","sequence":"first","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"},{"name":"Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Suotunen","sequence":"additional","affiliation":[{"name":"Turku PET Centre, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Rummukainen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanna-Kaisa","family":"Herukka","sequence":"additional","affiliation":[{"name":"Neurology of NeuroCenter, Kuopio University Hospital, Kuopio, Finland"},{"name":"Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ossi","family":"Nerg","sequence":"additional","affiliation":[{"name":"Neurology of NeuroCenter, Kuopio University Hospital, Kuopio, 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