{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:17:28Z","timestamp":1777396648113,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2019,2,19]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Amyloid pathology is a key feature of Alzheimer\u2019s disease (AD) and can be assessed in vivo with amyloid positron emission tomography (PET) imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      The objective of this study was to evaluate the incremental value of a PET scan with [\n                      <jats:sup>18<\/jats:sup>\n                      F]florbetaben, in terms of changes of diagnosis, diagnostic confidence, and treatment plan when added to a standardized diagnostic workup for cognitive disorders, with particular focus on the role of the neuropsychological assessment, including the Free and Cued Selective Reminding Test (FCSRT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 104 patients (69 mild cognitive impairment, 35 dementia), with diagnostic uncertainty after diagnostic workup, were recruited from our memory clinic. [\n                      <jats:sup>18<\/jats:sup>\n                      F]florbetaben PET scans were interpreted as amyloid negative or positive on the basis of a semi-quantitative visual rating. Clinical diagnosis and diagnostic confidence for AD or non-AD dementia were rated before and after PET result disclosure, as was the impact of PET on the patient management plan.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 69\/104 (66%) [\n                      <jats:sup>18<\/jats:sup>\n                      F]florbetaben positive scans, 51\/62 (82%) patients were suspected as having AD before the PET scan and 18\/42 (43%) were not. Overall, the data obtained at PET changed 18\/104 diagnoses (17%) and increased diagnostic confidence from 69.1\u00b18.1% to 83.5\u00b19.1 ( p\u200a&lt;\u200a0.001), with the greatest impact on diagnosis and confidence in PET negative patients with an initial diagnosis of AD ( p\u200a&lt;\u200a0.01) and in early-onset patients ( p\u200a=\u200a0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Amyloid PET represents a source of added value in dementia diagnosis, with a significant effect on diagnosis and diagnostic confidence. However, the use of a complete neuropsychological assessment has an add-on value on limiting the amyloid PET influence on change of diagnosis, and the real impact of amyloid PET should always be weighed up together with an accurate standardized diagnostic workup.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-180646","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T21:04:53Z","timestamp":1548191093000},"page":"1235-1244","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Incremental Diagnostic Value of [\n                    <sup>18<\/sup>\n                    F]Florbetaben PET and the Pivotal Role of the Neuropsychological Assessment in Clinical Practice"],"prefix":"10.1177","volume":"67","author":[{"given":"Marco","family":"Spallazzi","sequence":"first","affiliation":[{"name":"Department of Neurology, G. da Saliceto Hospital, Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Barocco","sequence":"additional","affiliation":[{"name":"Alzheimer Center, Briolini Hospital, Gazzaniga, Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Michelini","sequence":"additional","affiliation":[{"name":"Department of Psychology, Sigmund Freud University, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Neurology, G. da Saliceto Hospital, Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura","family":"Scarlattei","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Azienda Ospedaliero-Universitaria, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Baldari","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Azienda Ospedaliero-Universitaria, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Ruffini","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Azienda Ospedaliero-Universitaria, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Caffarra","sequence":"additional","affiliation":[{"name":"Alzheimer Center, Briolini Hospital, Gazzaniga, Bergamo, Italy"},{"name":"Department of Medicine and Surgery, Section of Neuroscience, University of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001991"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70090-0"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww160"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1025-1"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1185-7"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4668"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4669"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.01.002"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.127068"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.185017"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-171093"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1159\/000478007"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318279d02a"},{"key":"ref016","first-page":"184","volume":"256","author":"Boccardi M","year":"2016","journal-title":"JAMA Neurol"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1159\/000345783"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1159\/000339367"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151180"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.07.003"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160302"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827f0fd1"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.922"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-011-1821-1"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70077-1"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.01.021"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150418"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24125"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.02.004"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-016-0228-4"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1097\/01.JGP.0000231744.69631.33"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.12060158"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-180646","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:58Z","timestamp":1777370938000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-180646"}},"subtitle":[],"editor":[{"given":"Carlo","family":"Abbate","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,21]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,2,19]]}},"alternative-id":["10.3233\/JAD-180646"],"URL":"https:\/\/doi.org\/10.3233\/jad-180646","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,21]]}}}