{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:13:50Z","timestamp":1777396430513,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2018,11,23]]},"abstract":"<jats:p>The toxicity associated with long-standing benzodiazepine use in older persons is a critical issue. Several epidemiological reports have studied correlation between benzodiazepine use and risk of dementia development. In this manuscript, we used a case report to demonstrate how chronic diazepam use can cause cognitive deficits that resemble Alzheimer\u2019s disease and related conditions. Benzodiazepine use is common in the geriatric population and is often taken for long periods of time in improper doses. In combination with age-related cortical atrophy on the MRI, our patient risked being misdiagnosed with Alzheimer\u2019s disease or another dementing disorder if not for the systematic investigation to resolve his symptoms. With elimination of the offending dispensable drug (diazepam), the patient\u2019s cognition improved greatly.<\/jats:p>","DOI":"10.3233\/jad-180745","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T12:15:51Z","timestamp":1541160951000},"page":"935-938","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Diazepam Toxicity Presenting as a Dementia Disorder"],"prefix":"10.1177","volume":"66","author":[{"given":"Zimple","family":"Kurlawala","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Roberts","sequence":"additional","affiliation":[{"name":"University of Louisville, School of Medicine, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"McMillan","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Friedland","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2013.827660"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.1763"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.9.1107"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2001.119456"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03772.x"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.07.024"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000099"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1159\/000454881"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i90"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.05.004"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.1.25"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(87)90570-3"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2456"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01124-1"},{"key":"ref015","author":"Zaric BL","year":"2018","journal-title":"Curr Med Chem"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-197803010-00005"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13702"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2015.055"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145710001434"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180745","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-180745","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-180745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:25Z","timestamp":1777370905000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-180745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,2]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,11,23]]}},"alternative-id":["10.3233\/JAD-180745"],"URL":"https:\/\/doi.org\/10.3233\/jad-180745","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,2]]}}}