{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:49:40Z","timestamp":1789192180898,"version":"build-2803163510"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2019,3,29]]},"DOI":"10.3233\/jad-180785","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T14:30:29Z","timestamp":1549981829000},"page":"517-521","source":"Crossref","is-referenced-by-count":13,"title":["Cognitive Reserve in Midlife is not Associated with Amyloid-\u03b2 Deposition in Late-Life"],"prefix":"10.1177","volume":"68","author":[{"given":"Andreea M.","family":"Rawlings","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"},{"name":"Kaiser Permanente Center for Health Research, Portland, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Richey","family":"Sharrett","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Mosley","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean F.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Radiology, Neurology, Psychiatry, and Neurosciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Knopman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca F.","family":"Gottesman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-180785_ref1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1017\/S0033291705006264","article-title":"Brain reserve and dementia: A systematic review","volume":"36","author":"Valenzuela","year":"2006","journal-title":"Psychol Med"},{"issue":"Suppl 2","key":"10.3233\/JAD-180785_ref2","first-page":"50","article-title":"Brain reserve and the clinical expression of Alzheimer\u2019s disease.S","volume":"52","author":"Mortimer","year":"1997","journal-title":"Geriatrics"},{"key":"10.3233\/JAD-180785_ref3","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1212\/WNL.45.8.1446","article-title":"Intelligence and education as predictors of cognitive state in late life: A 50-year follow-up","volume":"45","author":"Plassman","year":"1995","journal-title":"Neurology"},{"key":"10.3233\/JAD-180785_ref4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neurobiolaging.2004.06.019","article-title":"Early life linguistic ability, late life cognitive function, and neuropathology: Findings from the Nun Study","volume":"26","author":"Riley","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-180785_ref5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3233\/JAD-171168","article-title":"Effect of education on Alzheimer\u2019s disease-related neuroimaging biomarkers in healthy controls, and participants with mild cognitive impairment and Alzheimer\u2019s disease: A cross-sectional study","volume":"63","author":"Wada","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-180785_ref6","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1093\/brain\/awq185","article-title":"Education, the brain and dementia: Neuroprotection or compensation?","volume":"133","author":"Brayne","year":"2010","journal-title":"Brain"},{"key":"10.3233\/JAD-180785_ref7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1212\/WNL.0000000000002914","article-title":"The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE","volume":"87","author":"Gottesman","year":"2016","journal-title":"Neurology"},{"key":"10.3233\/JAD-180785_ref8","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1097\/EDE.0000000000000379","article-title":"Application of latent variable methods to the study of cognitive decline when tests change over time","volume":"26","author":"Gross","year":"2015","journal-title":"Epidemiology"},{"key":"10.3233\/JAD-180785_ref9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jagp.2015.02.002","article-title":"A life-course study of cognitive reserve in dementia\u2014from childhood to old age","volume":"23","author":"Dekhtyar","year":"2015","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-180785_ref10","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/ana.23665","article-title":"Effect of lifestyle activities on alzheimer disease biomarkers and cognition","volume":"72","author":"Vemuri","year":"2012","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-180785_ref11","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1001\/jamaneurol.2017.0244","article-title":"Evaluation of amyloid protective factors and alzheimer disease neurodegeneration protective factors in elderly individuals","volume":"74","author":"Vemuri","year":"2017","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-180785_ref12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neurobiolaging.2017.09.002","article-title":"Cognitive reserve and long-term change in cognition in aging and preclinical Alzheimer\u2019s disease","volume":"60","author":"Soldan","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-180785_ref13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jalz.2016.08.005","article-title":"Defining imaging biomarker cut points for brain aging and Alzheimer\u2019s disease","volume":"13","author":"Jack","year":"2017","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-180785_ref14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-180785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:09Z","timestamp":1777370949000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-180785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,29]]},"references-count":14,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-180785","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,29]]}}}