{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:15:33Z","timestamp":1778336133935,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2019,3,12]]},"DOI":"10.3233\/jad-180815","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T21:45:28Z","timestamp":1548193528000},"page":"105-114","source":"Crossref","is-referenced-by-count":5,"title":["Apolipoprotein E4 Mediates the Association Between Midlife Dyslipidemia and Cerebral Amyloid in Aging Women"],"prefix":"10.1177","volume":"68","author":[{"given":"Cassandra","family":"Szoeke","sequence":"first","affiliation":[{"name":"Centre for Medical Research (Royal Melbourne Hospital), Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, Australia"},{"name":"Healthy Brain Initiative, Faculty of Health Science, Australian Catholic University, Melbourne, VIC, Australia"},{"name":"Healthy Ageing Organisation, Melbourne, Parkville, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia M.","family":"Goodwill","sequence":"additional","affiliation":[{"name":"Healthy Brain Initiative, Faculty of Health Science, Australian Catholic University, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Gorelik","sequence":"additional","affiliation":[{"name":"Healthy Brain Initiative, Faculty of Health Science, Australian Catholic University, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Dennerstein","sequence":"additional","affiliation":[{"name":"Centre for Medical Research (Royal Melbourne Hospital), Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Caeyenberghs","sequence":"additional","affiliation":[{"name":"Healthy Brain Initiative, Faculty of Health Science, Australian Catholic University, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Simpson","sequence":"additional","affiliation":[{"name":"Healthy Brain Initiative, Faculty of Health Science, Australian Catholic University, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Hill","sequence":"additional","affiliation":[{"name":"Healthy Brain Initiative, Faculty of Health Science, Australian Catholic University, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Campbell","sequence":"additional","affiliation":[{"name":"Healthy Ageing Organisation, Melbourne, Parkville, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-180815_ref1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1212\/WNL.51.3.728","article-title":"The incidence of dementia: A Meta-analysis","volume":"51","author":"Jorm","year":"1998","journal-title":"Neurology"},{"key":"10.3233\/JAD-180815_ref2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-beta and tau: The Trigger and bullet in Alzheimer disease pathogenesis","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-180815_ref3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer\u2019s disease: A Prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-180815_ref4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.4088\/JCP.15m09989","article-title":"The clinical picture of Alzheimer\u2019s disease in the decade before diagnosis: Clinical and biomarker trajectories","volume":"77","author":"Ritchie","year":"2016","journal-title":"J Clin Psychiatry"},{"key":"10.3233\/JAD-180815_ref5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrd4570","article-title":"What does it take to produce a breakthrough drug?","volume":"14","author":"Calcoen","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"10.3233\/JAD-180815_ref6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.7326\/0003-4819-137-3-200208060-00006","article-title":"Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease","volume":"137","author":"Kivipelto","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.3233\/JAD-180815_ref7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000231980","article-title":"Midlife serum cholesterol and increased risk of Alzheimer\u2019s and vascular dementia three decades later","volume":"28","author":"Solomon","year":"2009","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-180815_ref8","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1212\/01.wnl.0000256368.57375.b7","article-title":"Serum cholesterol changes after midlife and late-life cognition: Twenty-one-year follow-up study","volume":"68","author":"Solomon","year":"2007","journal-title":"Neurology"},{"key":"10.3233\/JAD-180815_ref9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1212\/01.WNL.0000149519.47454.F2","article-title":"Midlife cardiovascular risk factors and risk of dementia in late life","volume":"64","author":"Whitmer","year":"2005","journal-title":"Neurology"},{"key":"10.3233\/JAD-180815_ref10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/jamaneurol.2013.5390","article-title":"Associations between serum cholesterol levels and cerebral amyloidosis","volume":"71","author":"Reed","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-180815_ref11","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1001\/jamaneurol.2017.0244","article-title":"Evaluation of amyloid protective factors and Alzheimer disease neurodegeneration protective factors in elderly individuals","volume":"74","author":"Vemuri","year":"2017","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-180815_ref12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1212\/WNL.0000000000004749","article-title":"Increased midlife triglycerides predict brain beta-amyloid and tau pathology 20 years later","volume":"90","author":"Nagga","year":"2018","journal-title":"Neurology"},{"key":"10.3233\/JAD-180815_ref13","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1001\/jama.2017.3090","article-title":"Association between midlife vascular risk factors and estimated brain amyloid deposition","volume":"317","author":"Gottesman","year":"2017","journal-title":"JAMA"},{"key":"10.3233\/JAD-180815_ref14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0002-9149(00)00918-8","article-title":"Population frequency distribution of non-high-density lipoprotein cholesterol (Third National Health and Nutrition Examination Survey [NHANES III], 1988-1994)","volume":"86","author":"Gardner","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.3233\/JAD-180815_ref15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.trci.2015.07.001","article-title":"Marked gender differences in progression of mild cognitive impairment over 8 years","volume":"1","author":"Lin","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-180815_ref16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/ana.24135","article-title":"Sex modifies the APOE-related risk of developing Alzheimer disease","volume":"75","author":"Altmann","year":"2014","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-180815_ref17","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1042\/BST0381021","article-title":"Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment","volume":"38","author":"Leoni","year":"2010","journal-title":"Biochem Soc Trans"},{"key":"10.3233\/JAD-180815_ref18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40695-016-0018-y","article-title":"Cohort profile: Women\u2019s Healthy Ageing Project (WHAP) - a longitudinal prospective study of Australian women since 1990","volume":"2","author":"Szoeke","year":"2016","journal-title":"Womens Midlife Health"},{"key":"10.3233\/JAD-180815_ref19","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"10.3233\/JAD-180815_ref20","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.2967\/jnumed.116.187351","article-title":"Optimal reference region to measure longitudinal amyloid-beta change with (18)F-Florbetaben PET","volume":"58","author":"Bullich","year":"2017","journal-title":"J Nucl Med"},{"key":"10.3233\/JAD-180815_ref21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jalz.2017.07.757","article-title":"Association of midlife lipids with 20-year cognitive change: A Cohort study","volume":"14","author":"Power","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-180815_ref22","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.03.013","article-title":"APOE genotype modifies the relationship between midlife vascular risk factors and later cognitive decline","volume":"22","author":"Bangen","year":"2013","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.3233\/JAD-180815_ref23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0002-9343(97)00261-1","article-title":"Estrogen, cognition, and a woman\u2019s risk of Alzheimer\u2019s disease","volume":"103","author":"Henderson","year":"1997","journal-title":"Am J Med"},{"key":"10.3233\/JAD-180815_ref24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00002093-199910000-00007","article-title":"Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease","volume":"13","author":"Bretsky","year":"1999","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.3233\/JAD-180815_ref25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s11682-013-9272-x","article-title":"Apolipoprotein E, gender, and Alzheimer\u2019s disease: An Overlooked, but potent and promising interaction","volume":"8","author":"Ungar","year":"2014","journal-title":"Brain Imaging Behav"},{"key":"10.3233\/JAD-180815_ref26","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1212\/WNL.0000000000000033","article-title":"Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women","volume":"82","author":"Bove","year":"2014","journal-title":"Neurology"},{"key":"10.3233\/JAD-180815_ref27","first-page":"991","article-title":"Is surgical menopause associated with future levels of cardiovascular risk factor independent of antecedent Levels? The CARDIA study","volume":"182","author":"Appiah","year":"2015","journal-title":"Am J Epidemiol"},{"key":"10.3233\/JAD-180815_ref28","doi-asserted-by":"crossref","first-page":"12956","DOI":"10.1038\/s41598-018-31347-z","article-title":"Risk of hyperlipidemia in women with hysterectomy-a retrospective cohort study in Taiwan","volume":"8","author":"Li","year":"2018","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-180815_ref29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.18203\/2349-3933.ijam20175519","article-title":"Effect of surgical menopause on serum lipid profile-a prospective study","volume":"5","author":"Renymol","year":"2018","journal-title":"Int J Adv Med"},{"key":"10.3233\/JAD-180815_ref30","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1016\/j.jacc.2013.11.002","article-title":"ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A Report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Stone","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.3233\/JAD-180815_ref31","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1001\/jamaneurol.2013.2152","article-title":"Cerebrovascular effects of apolipoprotein e: Implications for alzheimer disease","volume":"70","author":"Zlokovic","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-180815_ref32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.redox.2012.12.001","article-title":"Oxysterols in the pathogenesis of major chronic diseases","volume":"1","author":"Poli","year":"2013","journal-title":"Redox Biol"},{"key":"10.3233\/JAD-180815_ref33","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0021-9150(00)00570-0","article-title":"Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study","volume":"154","author":"Lahoz","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.3233\/JAD-180815_ref34","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/alzrt6","article-title":"Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease","volume":"1","author":"Weller","year":"2009","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-180815_ref35","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1194\/jlr.M300320-JLR200","article-title":"Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer\u2019s disease","volume":"45","author":"Heverin","year":"2004","journal-title":"J Lipid Res"},{"key":"10.3233\/JAD-180815_ref36","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1172\/JCI118336","article-title":"Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma","volume":"96","author":"Huang","year":"1995","journal-title":"J Clin Invest"},{"key":"10.3233\/JAD-180815_ref37","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.5603\/KP.2016.0157","article-title":"ESC\/EAS Guidelines for the management of dyslipidaemias","volume":"74","author":"Catapano","year":"2016","journal-title":"Kardiol Pol"},{"key":"10.3233\/JAD-180815_ref38","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1161\/CIR.0b013e318235eb4d","article-title":"AHA\/ACCF Secondary Prevention and Risk Reduction Therapy for Patients with Coronary and other Atherosclerotic Vascular Disease: 2011 update: A guideline from the American Heart Association and American College of Cardiology Foundation","volume":"124","author":"Smith","year":"2011","journal-title":"Circulation"},{"key":"10.3233\/JAD-180815_ref39","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jacc.2013.01.079","article-title":"Friedewald-estimated versus directly measured low-density lipoprotein cholesterol and treatment implications","volume":"62","author":"Martin","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.3233\/JAD-180815_ref40","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.atherosclerosis.2004.07.005","article-title":"Small low-density lipoprotein particles and endothelium-dependent vasodilation in postmenopausal women","volume":"177","author":"Wakatsuki","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.3233\/JAD-180815_ref41","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/jama.1996.03540110036029","article-title":"A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction","volume":"276","author":"Stampfer","year":"1996","journal-title":"JAMA"},{"key":"10.3233\/JAD-180815_ref42","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/clinchem\/47.5.893","article-title":"Relationship between triglyceride concentrations and LDL size evaluated by malondialdehyde-modified LDL","volume":"47","author":"Kondo","year":"2001","journal-title":"Clin Chem"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-180815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:03Z","timestamp":1777370943000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-180815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,12]]},"references-count":42,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-180815","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,12]]}}}