{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:08:23Z","timestamp":1785409703993,"version":"3.56.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2019,3,12]]},"DOI":"10.3233\/jad-180912","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T14:36:15Z","timestamp":1549982175000},"page":"127-136","source":"Crossref","is-referenced-by-count":16,"title":["Antiepileptic Drug Use Is Associated with an Increased Risk of Pneumonia Among Community-Dwelling Persons with Alzheimer\u2019s Disease-Matched Cohort Study"],"prefix":"10.1177","volume":"68","author":[{"given":"Heidi","family":"Taipale","sequence":"first","affiliation":[{"name":"Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland"},{"name":"School of Pharmacy, University of Eastern Finland, Kuopio, Finland"},{"name":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasi","family":"Lampela","sequence":"additional","affiliation":[{"name":"Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland"},{"name":"School of Pharmacy, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjaana","family":"Koponen","sequence":"additional","affiliation":[{"name":"Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland"},{"name":"School of Pharmacy, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Tanskanen","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio, Finland"},{"name":"Impact Assessment Unit, National Institute for Health and Welfare, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Tiihonen","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio, Finland"},{"name":"Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirpa","family":"Hartikainen","sequence":"additional","affiliation":[{"name":"Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland"},{"name":"School of Pharmacy, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Maija","family":"Tolppanen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Eastern Finland, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-180912_ref1","volume-title":"Dementia: a public health priority","author":"World Health Organization","year":"2012"},{"key":"10.3233\/JAD-180912_ref2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jalz.2011.02.004","article-title":"Alzheimer\u2019s disease facts and figures","volume":"7","author":"Association","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-180912_ref3","unstructured":"(2010) Practice guideline for the treatment of patients with major depressive disorder, American Psychiatric Association."},{"key":"10.3233\/JAD-180912_ref5","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.2147\/NDT.S163842","article-title":"Treatment of behavioral and psychological symptoms of dementias with psychopharmaceuticals:a review","volume":"14","author":"Masopust.","year":"2018","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.3233\/JAD-180912_ref6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.eplepsyres.2017.11.001","article-title":"Utilisation and polypharmacy aspects of antiepileptic drugs in elderly versus younger patients with epilepsy:A pharmacoepidemiological study of CNS-active drugs in Norway, 2004-2015","volume":"139","author":"Baftiu","year":"2018","journal-title":"Epilepsy Res"},{"key":"10.3233\/JAD-180912_ref7","first-page":"3","article-title":"Management of community-acquired pneumonia in older adults","volume":"2","author":"Simonetti","year":"2014","journal-title":"Ther Adv Infect Dis"},{"key":"10.3233\/JAD-180912_ref8","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1111\/j.1532-5415.2010.02924.x","article-title":"Hospitalization in community-dwelling persons with Alzheimer\u2019s disease: frequency and causes","volume":"58","author":"Rudolph","year":"2010","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-180912_ref9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000367783","article-title":"A systematic review and meta-analysis examining pneumonia-associated mortality in dementia","volume":"39","author":"Foley","year":"2015","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-180912_ref10","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.chest.2016.06.004","article-title":"Antipsychotic use and risk of hospitalization or death due to pneumonia in persons with and those without Alzheimer disease","volume":"150","author":"Tolppanen","year":"2016","journal-title":"Chest"},{"key":"10.3233\/JAD-180912_ref11","doi-asserted-by":"crossref","first-page":"E519","DOI":"10.1503\/cmaj.160126","article-title":"Risk of pneumonia associated with incident benzodiazepine use among community-dwelling adults with Alzheimer disease","volume":"189","author":"Taipale","year":"2017","journal-title":"Can Med Assoc J"},{"key":"10.3233\/JAD-180912_ref12","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.4088\/JCP.12m07938","article-title":"Antipsychotic drugs, mood stabilizers, and risk of pneumonia in bipolar disorder: a nationwide case-control study","volume":"74","author":"Yang","year":"2013","journal-title":"J Clin Psychiatry"},{"key":"10.3233\/JAD-180912_ref13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3988\/jcn.2008.4.3.99","article-title":"Cognitive effects of antiepileptic drugs","volume":"4","author":"Park","year":"2008","journal-title":"J Clin Neurol"},{"key":"10.3233\/JAD-180912_ref14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/1756285611417920","article-title":"The cognitive impact of antiepileptic drugs","volume":"4","author":"Eddy","year":"2011","journal-title":"Ther Adv Neurol Disord"},{"key":"10.3233\/JAD-180912_ref15","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1001\/archinte.159.17.2058","article-title":"Risk factors for pneumonia and other lower respiratory tract infections in elderly residents of long-term care facilities","volume":"159","author":"Loeb","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.3233\/JAD-180912_ref16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3233\/JAD-2011-110200","article-title":"Use of antiepileptic drugs among community-dwelling persons with Alzheimer\u2019s disease in Finland","volume":"26","author":"Bell","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-180912_ref17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nrneurol.2009.39","article-title":"Management of agitation and aggression associated with Alzheimer disease","volume":"5","author":"Ballard","year":"2009","journal-title":"Nat Rev Neurol"},{"key":"10.3233\/JAD-180912_ref18","doi-asserted-by":"crossref","first-page":"e012100","DOI":"10.1136\/bmjopen-2016-012100","article-title":"Cohort profile: the Finnish Medication and Alzheimer\u2019s disease (MEDALZ) study","volume":"6","author":"Tolppanen","year":"2016","journal-title":"BMJ Open"},{"key":"10.3233\/JAD-180912_ref19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.3233\/JAD-180912_ref20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jalz.2013.03.004","article-title":"Validity of dementia and Alzheimer\u2019s disease diagnoses in Finnish national registers","volume":"10","author":"Solomon","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-180912_ref22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12911-015-0140-z","article-title":"From prescription drug purchases to drug use periods \u2013 a second generation method (PRE2DUP)","volume":"15","author":"Tanskanen","year":"2015","journal-title":"BMC Med Inform Decis Mak"},{"key":"10.3233\/JAD-180912_ref23","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/j.pain.0000000000000752","article-title":"Long-term use of opioids for non-malignant pain among community-dwelling persons with and without Alzheimer\u2019s disease in Finland","volume":"158","author":"Hamina","year":"2017","journal-title":"Pain"},{"key":"10.3233\/JAD-180912_ref24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000052811","article-title":"Risk factors of aspiration pneumonia in Alzheimer\u2019s disease patients","volume":"47","author":"Wada","year":"2001","journal-title":"Gerontology"},{"key":"10.3233\/JAD-180912_ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-016-1974-4","article-title":"Incidence and risk factor prevalence of community-acquired pneumonia in adults in primary care in Spain (NEUMO-ES-RISK project)","volume":"16","author":"Rivero-Calle","year":"2016","journal-title":"BMC Infect Dis"},{"key":"10.3233\/JAD-180912_ref26","doi-asserted-by":"crossref","first-page":"M384","DOI":"10.1093\/gerona\/55.7.M384","article-title":"Factors associated with antiepileptic drug use among elderly nursing home residents","volume":"55A","author":"Garrard","year":"2000","journal-title":"J Gerontol Med Sci"},{"key":"10.3233\/JAD-180912_ref27","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00228-011-1051-2","article-title":"Antiepileptic drug use in community-dwelling and institutionalized elderly: a nationwide study of over 1,300,000 older people","volume":"67","author":"Johnell","year":"2011","journal-title":"Eur J Clin Pharmacol"},{"key":"10.3233\/JAD-180912_ref28","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/jgs.12325","article-title":"Modifiable risk factors for pneumonia requiring hospitalization of community-dwelling older adults: The health, aging, and body composition study","volume":"61","author":"Juthani-Mehta","year":"2013","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JAD-180912_ref29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40266-014-0229-6","article-title":"Recurrent pneumonia: a review with focus on clinical epidemiology and modifiable risk factors in elderly patients","volume":"32","author":"Dang","year":"2014","journal-title":"Drugs Aging"},{"key":"10.3233\/JAD-180912_ref30","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.anai.2016.09.443","article-title":"Antiepilepsy drugs and the immune system","volume":"117","author":"Godhwani","year":"2016","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.3233\/JAD-180912_ref31","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1111\/bcp.13296","article-title":"Do antiepileptic drugs increase the risk of infectious diseases? A meta-analysis of placebo-controlled studies","volume":"83","author":"Zaccara","year":"2017","journal-title":"Br J Clin Pharmacol"},{"key":"10.3233\/JAD-180912_ref32","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1535-7511.2005.00056.x","article-title":"Psychotropic effects of antiepileptic drugs","volume":"5","author":"Nadkarni","year":"2005","journal-title":"Epilepsy Curr"},{"key":"10.3233\/JAD-180912_ref33","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-444-52891-9.00073-7","volume-title":"Cognitive side-effects of antiepileptic drugs in children","author":"Ijff","year":"2013"},{"key":"10.3233\/JAD-180912_ref34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00213-005-0172-7","article-title":"A double-blind, placebo- and positive-internal-controlled (alprazolam) investigation of the cognitive and psychomotor profile of pregabalin in healthy volunteers","volume":"183","author":"Hindmarch","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.3233\/JAD-180912_ref35","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/bja\/aen215","article-title":"Pregabalin and dexamethasone for postoperative pain control: A randomized controlled study in hip arthroplasty","volume":"101","author":"Mathiesen","year":"2008","journal-title":"Br J Anaesth"},{"key":"10.3233\/JAD-180912_ref36","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.yebeh.2006.07.011","article-title":"Neuropsychological and psychiatric impact of add-on titration of pregabalin versus levetiracetam: A comparative short-term study","volume":"9","author":"Ciesielski","year":"2006","journal-title":"Epilepsy Behav"},{"key":"10.3233\/JAD-180912_ref37","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1528-1167.2010.02966.x","article-title":"The adverse event profile of pregabalin: A systematic review and meta-analysis of randomized controlled trials","volume":"52","author":"Zaccara","year":"2011","journal-title":"Epilepsia"},{"key":"10.3233\/JAD-180912_ref38","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1586\/ern.10.71","article-title":"Adverse effects of antiepileptic drugs: A brief overview of important issues","volume":"10","author":"Cramer","year":"2010","journal-title":"Expert Rev Neurother"},{"key":"10.3233\/JAD-180912_ref39","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.pain.2013.11.013","article-title":"Neuropathic pain in the general population: A systematic review of epidemiological studies","volume":"155","author":"Van Hecke","year":"2014","journal-title":"Pain"},{"key":"10.3233\/JAD-180912_ref40","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s40266-015-0294-5","article-title":"Neuropathic pain among community-dwelling older people: A clinical study in Finland","volume":"32","author":"Rapo-Pylkk\u00f6","year":"2015","journal-title":"Drugs Aging"},{"issue":"Suppl 2","key":"10.3233\/JAD-180912_ref41","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1111\/j.1526-4637.2011.01307.x","article-title":"Treatment guidelines for the pharmacological management of pain in older persons","volume":"13","author":"Fine","year":"2012","journal-title":"Pain Med"},{"issue":"Suppl 1","key":"10.3233\/JAD-180912_ref42","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1093\/ageing\/afs200","article-title":"Guidance on the management of pain in older people","volume":"42","author":"Abdulla","year":"2013","journal-title":"Age Ageing"},{"key":"10.3233\/JAD-180912_ref43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2165\/00002018-200023030-00002","article-title":"A risk-benefit assessment of risperidone for the treatment of behavioural and psychological symptoms in dementia","volume":"23","author":"Zaudig","year":"2000","journal-title":"Drug Saf"},{"issue":"12 Suppl","key":"10.3233\/JAD-180912_ref44","first-page":"5","article-title":"American Psychiatric Association practice guideline for the treatment of patients with Alzheimer\u2019s disease and other dementias. Second edition","volume":"164","author":"Rabins","year":"2007","journal-title":"Am J Psychiatry"},{"key":"10.3233\/JAD-180912_ref45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1176\/appi.neuropsych.12050115","article-title":"Use of low-dose gabapentin for aggressive behavior in vascular and mixed vascular\/Alzheimer dementia","volume":"25","author":"Cooney","year":"2013","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.3233\/JAD-180912_ref46","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/jgs.12730","article-title":"Expert Panel on Assessment and Management of Neuropsychiatric Symptoms of Dementia (2014) Management of neuropsychiatric symptoms of dementia in clinical settings: recommendations from a multidisciplinary expert panel","volume":"62","author":"Kales","journal-title":"J Am Geriatr Soc"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-180912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:03Z","timestamp":1777370943000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-180912"}},"subtitle":[],"editor":[{"given":"Julia","family":"Gilmartin-Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,12]]},"references-count":44,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-180912","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,12]]}}}