{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:18:11Z","timestamp":1777396691316,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2019,3,12]]},"DOI":"10.3233\/jad-180977","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T14:40:29Z","timestamp":1549982429000},"page":"357-365","source":"Crossref","is-referenced-by-count":9,"title":["Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer\u2019s Disease Associates with Increased Odds for Brain Infarcts"],"prefix":"10.1177","volume":"68","author":[{"given":"Sarah C.","family":"Conner","sequence":"first","affiliation":[{"name":"Framingham Heart Study, Boston University School of Public Health, Boston, MA, USA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Benayoun","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayandra J.","family":"Himali","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Boston University School of Public Health, Boston, MA, USA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"},{"name":"Department of Neurology, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Yang","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Boston University School of Public Health, Boston, MA, USA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan K.","family":"Blusztajn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa","family":"Beiser","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Boston University School of Public Health, Boston, MA, USA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"},{"name":"Department of Neurology, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Boston University School of Public Health, Boston, MA, USA"},{"name":"Department of Neurology, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Delalle","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA"},{"name":"Department of Neurology, Boston University School of Medicine, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-180977_ref1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.freeradbiomed.2017.02.010","article-title":"Regulated methionine oxidation by monooxygenases","volume":"109","author":"Manta","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"10.3233\/JAD-180977_ref2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.abb.2012.03.029","article-title":"Methionine sulfoxide reductase contributes to meeting dietary methionine requirements","volume":"522","author":"Zhao","year":"2012","journal-title":"Arch Biochem Biophys"},{"key":"10.3233\/JAD-180977_ref3","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1089\/ars.2015.6385","article-title":"Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1","volume":"23","author":"Kaya","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"10.3233\/JAD-180977_ref4","doi-asserted-by":"crossref","first-page":"13624","DOI":"10.1038\/ncomms13624","article-title":"Novel genetic loci associated with hippocampal volume","volume":"8","author":"Hibar","year":"2017","journal-title":"Nat Commun"},{"key":"10.3233\/JAD-180977_ref5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3233\/JAD-170459","article-title":"Methionine sulfoxide reductase B3 (MsrB3) protein associates with synaptic vesicles and its expression changes in the hippocampi of Alzheimer\u2019s disease patients","volume":"60","author":"Adams","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-180977_ref6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa1504327","article-title":"Incidence of dementia over three decades in the Framingham Heart Study","volume":"374","author":"Satizabal","year":"2016","journal-title":"N Engl J Med"},{"key":"10.3233\/JAD-180977_ref7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jalz.2010.12.002","article-title":"Operationalizing diagnostic criteria for Alzheimer\u2019s disease and other age-related cognitive impairment-Part 2","volume":"7","author":"Seshadri","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-180977_ref8","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1001\/archneurol.2011.977","article-title":"Contributions of the Framingham Heart Study to stroke and dementia epidemiologic research at 60 years","volume":"69","author":"Wolf","year":"2012","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-180977_ref9","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/0091-7435(75)90037-7","article-title":"The Framingham Offspring Study. Design and preliminary data","volume":"4","author":"Feinleib","year":"1975","journal-title":"Prev Med"},{"key":"10.3233\/JAD-180977_ref10","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1093\/ije\/dyv336","article-title":"The Framingham Heart Study: Past, present and future","volume":"44","author":"Tsao","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.3233\/JAD-180977_ref11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.neurobiolaging.2004.05.004","article-title":"Measures of brain morphology and infarction in the Framingham Heart Study: Establishing what is normal","volume":"26","author":"DeCarli","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-180977_ref12","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.neuroimage.2009.02.018","article-title":"Multi-atlas based segmentation of brain images: Atlas selection and its effect on accuracy","volume":"46","author":"Aljabar","year":"2009","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-180977_ref13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/01.STR.0000150668.58689.f2","article-title":"Anatomical mapping of white matter hyperintensities (WMH): Exploring the relationships between periventricular WMH, deep WMH, and total WMH burden","volume":"36","author":"DeCarli","year":"2005","journal-title":"Stroke"},{"key":"10.3233\/JAD-180977_ref14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.3233\/JAD-180977_ref15","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.3233\/JAD-180977_ref16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/01.STR.22.3.312","article-title":"Probability of stroke: A risk profile from the Framingham Study","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"10.3233\/JAD-180977_ref17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ajhg.2010.11.010","article-title":"Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74","volume":"88","author":"Ahmed","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.3233\/JAD-180977_ref18","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1212\/WNL.0b013e31829bfda4","article-title":"APOE genotype and MRI markers of cerebrovascular disease: Systematic review and meta-analysis","volume":"81","author":"Schilling","year":"2013","journal-title":"Neurology"},{"key":"10.3233\/JAD-180977_ref19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.arr.2017.06.002","article-title":"Evolution of human apolipoprotein E (APOE) isoforms: Gene structure, protein function and interaction with dietary factors","volume":"37","author":"Huebbe","year":"2017","journal-title":"Ageing Res Rev"},{"key":"10.3233\/JAD-180977_ref20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-17121-0_1","article-title":"Apolipoprotein E isoforms and AMD","volume":"854","author":"Toops","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"10.3233\/JAD-180977_ref21","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.arcmed.2017.08.002","article-title":"Association of apolipoprotein E polymorphisms with age-related macular degeneration subtypes: An updated systematic review and meta-analysis","volume":"48","author":"Xiying","year":"2017","journal-title":"Arch Med Res"},{"key":"10.3233\/JAD-180977_ref22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/13816810.2018.1479429","article-title":"The role of apolipoprotein E (rs7412 and rs429358) in age-related macular degeneration","volume":"39","author":"Liutkeviciene","year":"2018","journal-title":"Ophthalmic Genet"},{"key":"10.3233\/JAD-180977_ref23","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1096\/fj.201601084R","article-title":"Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden","volume":"31","author":"Trumble","year":"2017","journal-title":"FASEB J"},{"key":"10.3233\/JAD-180977_ref24","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1001\/jamaneurol.2013.1957","article-title":"Neuropathologic basis of age-associated brain atrophy","volume":"70","author":"Erten-Lyons","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-180977_ref25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1212\/01.WNL.0000079053.77227.14","article-title":"Changes in premorbid brain volume predict Alzheimer\u2019s disease pathology","volume":"61","author":"Silbert","year":"2003","journal-title":"Neurology"},{"key":"10.3233\/JAD-180977_ref26","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S1474-4422(17)30284-3","article-title":"Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer\u2019s disease: A longitudinal retrospective study","volume":"16","author":"Josephs","year":"2017","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-180977_ref27","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.bbrc.2016.04.011","article-title":"Methionine sulfoxide reductase B3 deficiency stimulates heme oxygenase-1 expression via ROS-dependent and Nrf2 activation pathways","volume":"473","author":"Kwak","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-180977_ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(02)03670-3","article-title":"Neotrofin increases heme oxygenase-1 selectively in neurons","volume":"962","author":"Wang","year":"2003","journal-title":"Brain Res"},{"key":"10.3233\/JAD-180977_ref29","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1007\/s12035-016-9786-5","article-title":"Prevention of hippocampal neuronal damage and cognitive function deficits in vascular dementia by dextromethorphan","volume":"53","author":"Xu","year":"2016","journal-title":"Mol Neurobiol"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-180977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:04Z","timestamp":1777370944000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-180977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,12]]},"references-count":29,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jad-180977","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,12]]}}}