{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:08:41Z","timestamp":1791288521685,"version":"4.3.0"},"reference-count":61,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2019,4,8]]},"DOI":"10.3233\/jad-181038","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T13:43:34Z","timestamp":1552398214000},"page":"1171-1184","source":"Crossref","is-referenced-by-count":68,"title":["TREM2 Variants and Neurodegenerative Diseases: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"68","author":[{"given":"Sheng-Lan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Chen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-He","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Peng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-181038_ref1","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/ni1411","article-title":"The TREM receptor family and signal integration","volume":"7","author":"Klesney-Tait","year":"2006","journal-title":"Nat Immunol"},{"key":"10.3233\/JAD-181038_ref2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer\u2019s disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.3233\/JAD-181038_ref3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3233\/JAD-130854","article-title":"Increased expression of TREM2 in peripheral blood of Alzheimer\u2019s disease patients","volume":"38","author":"Hu","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-181038_ref4","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.jalz.2014.12.009","article-title":"The role of TREM2 R47H as a risk factor for Alzheimer\u2019s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson\u2019s disease","volume":"11","author":"Lill","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-181038_ref5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1750-1326-8-19","article-title":"TREM2 in neurodegeneration: Evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson\u2019s disease","volume":"8","author":"Rayaprolu","year":"2013","journal-title":"Mol Neurodegener"},{"key":"10.3233\/JAD-181038_ref6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/mp.2017.246","article-title":"Markers of microglia in post-mortem brain samples from patients with Alzheimer\u2019s disease: A systematic review","volume":"23","author":"Hopperton","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.3233\/JAD-181038_ref7","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1056\/NEJMcibr1503954","article-title":"TREM2 and risk of Alzheimer\u2019s disease\u2013friend or foe?","volume":"372","author":"Tanzi","year":"2015","journal-title":"N Engl J Med"},{"key":"10.3233\/JAD-181038_ref8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jns.2013.01.021","article-title":"Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL): A new report of an Italian woman and review of the literature","volume":"326","author":"Bock","year":"2013","journal-title":"J Neurol Sci"},{"key":"10.3233\/JAD-181038_ref9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1440-1789.2010.01127.x","article-title":"Nasu-Hakola disease: The first case reported by Nasu and review: The 50th Anniversary of Japanese Society of Neuropathology","volume":"30","author":"Kaneko","year":"2010","journal-title":"Neuropathology"},{"key":"10.3233\/JAD-181038_ref10","doi-asserted-by":"crossref","first-page":"194 e113","DOI":"10.1016\/j.neurobiolaging.2017.01.015","article-title":"A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature","volume":"53","author":"Dardiotis","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref11","doi-asserted-by":"crossref","first-page":"726 e711","DOI":"10.1016\/j.neurobiolaging.2013.09.009","article-title":"Investigating the role of rare heterozygous TREM2 variants in Alzheimer\u2019s disease and frontotemporal dementia","volume":"35","author":"Cuyvers","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref12","doi-asserted-by":"crossref","first-page":"546 e549","DOI":"10.1016\/j.neurobiolaging.2014.08.001","article-title":"TREM2 analysis and increased risk of Alzheimer\u2019s disease","volume":"36","author":"Finelli","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref13","doi-asserted-by":"crossref","first-page":"2889 e2811","DOI":"10.1016\/j.neurobiolaging.2013.06.004","article-title":"Assessment of TREM2 rs75932628 association with Alzheimer\u2019s disease in a population-based sample: The Cache County Study","volume":"34","author":"Gonzalez Murcia","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer\u2019s disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N Engl J Med"},{"key":"10.3233\/JAD-181038_ref15","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1212\/WNL.0000000000000855","article-title":"The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk","volume":"83","author":"Hooli","year":"2014","journal-title":"Neurology"},{"key":"10.3233\/JAD-181038_ref16","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1093\/hmg\/ddu277","article-title":"Coding variants in TREM2 increase risk for Alzheimer\u2019s disease","volume":"23","author":"Jin","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.3233\/JAD-181038_ref17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13024-015-0016-9","article-title":"TREM2 is associated with increased risk for Alzheimer\u2019s disease in African Americans","volume":"10","author":"Jin","year":"2015","journal-title":"Mol Neurodegener"},{"key":"10.3233\/JAD-181038_ref18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer\u2019s disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N Engl J Med"},{"key":"10.3233\/JAD-181038_ref19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1159\/000430842","article-title":"Association study of the TREM2 gene and identification of a novel variant in exon 2 in Iranian patients with late-onset Alzheimer\u2019s disease","volume":"24","author":"Mehrjoo","year":"2015","journal-title":"Med Princ Pract"},{"key":"10.3233\/JAD-181038_ref20","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.3233\/JAD-140225","article-title":"Lack of genetic association between TREM2 and late-onset Alzheimer\u2019s disease in a Japanese population","volume":"41","author":"Miyashita","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-181038_ref21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JAD-122311","article-title":"TREM2 R47H variant as a risk factor for early-onset Alzheimer\u2019s disease","volume":"35","author":"Pottier","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-181038_ref22","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.jalz.2014.10.013","article-title":"The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer\u2019s dementia","volume":"11","author":"Roussos","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-181038_ref23","doi-asserted-by":"crossref","first-page":"2443 e2421","DOI":"10.1016\/j.neurobiolaging.2015.04.012","article-title":"More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer\u2019s disease risk","volume":"36","author":"Rosenthal","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref24","doi-asserted-by":"crossref","first-page":"444 e441","DOI":"10.1016\/j.neurobiolaging.2013.08.011","article-title":"Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer\u2019s disease and frontotemporal dementia","volume":"35","author":"Ruiz","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref25","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jalz.2014.05.1751","article-title":"R47H TREM2 variant increases risk of typical early-onset Alzheimer\u2019s disease but not of prion or frontotemporal dementia","volume":"10","author":"Slattery","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-181038_ref26","doi-asserted-by":"crossref","first-page":"934 e937","DOI":"10.1016\/j.neurobiolaging.2013.09.017","article-title":"Heterozygous TREM2 mutations in frontotemporal dementia","volume":"35","author":"Borroni","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref27","doi-asserted-by":"crossref","first-page":"1711 e1715","DOI":"10.1016\/j.neurobiolaging.2012.12.018","article-title":"TREM2 is associated with the risk of Alzheimer\u2019s disease in Spanish population","volume":"34","author":"Benitez","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref28","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2016.03.009","article-title":"Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer\u2019s disease data set","volume":"42","author":"Ghani","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref29","doi-asserted-by":"crossref","first-page":"2077 e2011","DOI":"10.1016\/j.neurobiolaging.2013.02.016","article-title":"Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer\u2019s disease","volume":"34","author":"Giraldo","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref30","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/ng.3916","article-title":"Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer\u2019s disease","volume":"49","author":"Sims","year":"2017","journal-title":"Nat Genet"},{"key":"10.3233\/JAD-181038_ref31","doi-asserted-by":"crossref","first-page":"217 e211","DOI":"10.1016\/j.neurobiolaging.2016.02.023","article-title":"A rare coding variant in TREM2 increases risk for Alzheimer\u2019s disease in Han Chinese","volume":"42","author":"Jiang","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref32","doi-asserted-by":"crossref","first-page":"1958 e1913","DOI":"10.1016\/j.neurobiolaging.2014.03.007","article-title":"Exome array study did not identify novel variants in Alzheimer\u2019s disease","volume":"35","author":"Chung","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref33","first-page":"1567","article-title":"TREM2 and neurodegenerative disease","volume":"369","author":"Benitez","year":"2013","journal-title":"N Engl J Med"},{"key":"10.3233\/JAD-181038_ref34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1001\/jamaneurol.2013.6237","article-title":"TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis","volume":"71","author":"Cady","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-181038_ref35","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s10072-015-2274-2","article-title":"TREM2 variants and risk of Alzheimer\u2019s disease: A meta-analysis","volume":"36","author":"Lu","year":"2015","journal-title":"Neurol Sci"},{"key":"10.3233\/JAD-181038_ref36","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1212\/01.WNL.0000160304.00003.CA","article-title":"The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2","volume":"64","author":"Klunemann","year":"2005","journal-title":"Neurology"},{"key":"10.3233\/JAD-181038_ref37","doi-asserted-by":"crossref","first-page":"2890 e2891","DOI":"10.1016\/j.neurobiolaging.2013.06.005","article-title":"Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family","volume":"34","author":"Guerreiro","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref38","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/jnnp.74.6.825-a","article-title":"An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene","volume":"74","author":"Soragna","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-181038_ref39","doi-asserted-by":"crossref","first-page":"2419 e2423","DOI":"10.1016\/j.neurobiolaging.2014.04.010","article-title":"Homozygous TREM2 mutation in a family with atypical frontotemporal dementia","volume":"35","author":"Le Ber","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref40","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10048-015-0451-3","article-title":"Variable expression of microglial DAP12 and TREM2 genes in Nasu-Hakola disease","volume":"16","author":"Sasaki","year":"2015","journal-title":"Neurogenetics"},{"key":"10.3233\/JAD-181038_ref41","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1468-1331.2010.03311.x","article-title":"Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family","volume":"18","author":"Numasawa","year":"2011","journal-title":"Eur J Neurol"},{"key":"10.3233\/JAD-181038_ref42","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1086\/342259","article-title":"Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype","volume":"71","author":"Paloneva","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.3233\/JAD-181038_ref43","doi-asserted-by":"crossref","first-page":"E194","DOI":"10.1002\/humu.20836","article-title":"Mutations in TREM2 lead to pure early-onset dementia without bone cysts","volume":"29","author":"Chouery","year":"2008","journal-title":"Hum Mutat"},{"key":"10.3233\/JAD-181038_ref44","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1001\/jamaneurol.2013.579","article-title":"Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement","volume":"70","author":"Guerreiro","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-181038_ref45","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.20030027","article-title":"DAP12\/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features","volume":"198","author":"Paloneva","year":"2003","journal-title":"J Exp Med"},{"key":"10.3233\/JAD-181038_ref46","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neuropharm.2016.01.028","article-title":"TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice","volume":"105","author":"Jiang","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.3233\/JAD-181038_ref47","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/1533317515577128","article-title":"Lack of genetic association between TREM2 and Alzheimer\u2019s disease in East Asian population: A systematic review and meta-analysis","volume":"30","author":"Huang","year":"2015","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"10.3233\/JAD-181038_ref48","doi-asserted-by":"crossref","first-page":"937 e931","DOI":"10.1016\/j.neurobiolaging.2013.10.075","article-title":"Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer\u2019s disease in Han Chinese individuals","volume":"35","author":"Yu","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref49","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1179\/1743132814Y.0000000376","article-title":"Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer\u2019s disease in Chinese Han population","volume":"36","author":"Ma","year":"2014","journal-title":"Neurol Res"},{"key":"10.3233\/JAD-181038_ref50","doi-asserted-by":"crossref","first-page":"2422 e2429","DOI":"10.1016\/j.neurobiolaging.2014.04.025","article-title":"Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer\u2019s disease from mainland China","volume":"35","author":"Jiao","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref51","doi-asserted-by":"crossref","first-page":"318","DOI":"10.2174\/1567202613666160808095530","article-title":"TREM2 p.H157Y variant and the risk of Alzheimer\u2019s disease: A meta-analysis involving 14,510 subjects","volume":"13","author":"Jiang","year":"2016","journal-title":"Curr Neurovasc Res"},{"key":"10.3233\/JAD-181038_ref52","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cca.2016.10.022","article-title":"TREMs in Alzheimer\u2019s disease: Genetic and clinical investigations","volume":"463","author":"Cheng","year":"2016","journal-title":"Clin Chim Acta"},{"key":"10.3233\/JAD-181038_ref53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-015-0040-9","article-title":"TREM2 in CNS homeostasis and neurodegenerative disease","volume":"10","author":"Painter","year":"2015","journal-title":"Mol Neurodegener"},{"key":"10.3233\/JAD-181038_ref54","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.neuron.2016.05.003","article-title":"TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy","volume":"90","author":"Yuan","year":"2016","journal-title":"Neuron"},{"key":"10.3233\/JAD-181038_ref55","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/tra.12264","article-title":"Disease-associated mutations of TREM2 alter the processing of N-linked oligosaccharides in the Golgi apparatus","volume":"16","author":"Park","year":"2015","journal-title":"Traffic"},{"key":"10.3233\/JAD-181038_ref56","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1123511","article-title":"Onset and progression in inherited ALS determined by motor neurons and microglia","volume":"312","author":"Boillee","year":"2006","journal-title":"Science"},{"key":"10.3233\/JAD-181038_ref57","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.20142322","article-title":"TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer\u2019s disease mouse models","volume":"212","author":"Jay","year":"2015","journal-title":"J Exp Med"},{"key":"10.3233\/JAD-181038_ref58","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1523\/JNEUROSCI.2110-16.2016","article-title":"Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer\u2019s disease","volume":"37","author":"Jay","year":"2017","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-181038_ref59","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1016\/j.neurobiolaging.2015.08.019","article-title":"Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice","volume":"36","author":"Jiang","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-181038_ref60","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nri1106","article-title":"TREMs in the immune system and beyond","volume":"3","author":"Colonna","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.3233\/JAD-181038_ref61","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1016\/j.neurobiolaging.2013.05.001","article-title":"Insights into TREM2 biology by network analysis of human brain gene expression data","volume":"34","author":"Forabosco","year":"2013","journal-title":"Neurobiol Aging"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-181038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:18Z","timestamp":1777370958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/JAD-181038"}},"subtitle":[],"editor":[{"given":"Ling-Qiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,8]]},"references-count":61,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/jad-181038","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,8]]}}}