{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:41:30Z","timestamp":1790095290750,"version":"4.0.1"},"reference-count":49,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2019,8,20]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Measures of handgrip strength may show promise for detecting cognitive erosion during aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the associations between lower handgrip strength and poorer cognitive functioning for aging Americans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>There were 13,828 participants aged at least 50 years from the 2006 wave of the Health and Retirement Study included and followed biennially for 8 years. Handgrip strength was assessed with a hand-held dynamometer and cognitive functioning was assessed with a modified version of the Mini-Mental State Examination. Participants aged &lt;65 years with scores 7\u2013 11 had a mild cognitive impairment, \u22646 had a severe cognitive impairment, and \u226411 had any cognitive impairment. Respondents aged \u226565 years with scores 8\u2013 10 had a mild cognitive impairment, \u22647 had a severe cognitive impairment, and \u226410 had any cognitive impairment. Separate covariate-adjusted multilevel logistic models examined the associations between lower handgrip strength and any or severe cognitive impairment. A multilevel ordered logit model analyzed the association between lower handgrip strength and poorer cognitive functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Every 5-kg lower handgrip strength was associated with 1.10 (95% confidence interval (CI): 1.04, 1.15) and 1.18 (CI: 1.04, 1.32) greater odds for any and severe cognitive impairment, respectively. Similarly, every 5-kg lower handgrip strength was associated with 1.10 (CI: 1.05, 1.14) greater odds for poorer cognitive functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Measurement of handgrip strength is a simple, risk-stratifying method for helping healthcare providers determine poorer cognitive functioning. Interventions aiming to prevent or delay cognitive dysfunction should also implement measures of handgrip strength as an assessment tool for determining efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-190042","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T11:30:46Z","timestamp":1563276646000},"page":"1187-1196","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":100,"title":["Handgrip Strength Is Associated with Poorer Cognitive Functioning in Aging Americans"],"prefix":"10.1177","volume":"70","author":[{"given":"Ryan","family":"McGrath","sequence":"first","affiliation":[{"name":"Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheria G.","family":"Robinson-Lane","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Summer","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of New Hampshire, Durham, NH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Clark","sequence":"additional","affiliation":[{"name":"Ohio Musculoskeletal and Neurological Institute, Ohio University, Athens, OH, USA"},{"name":"Department of Biomedical Sciences, Ohio University, Athens, OH, USA"},{"name":"Department of Geriatric Medicine, Ohio University, Athens, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Sanford Research, Sioux Falls, SD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Lunsman","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Science, North Dakota State University, Fargo, ND, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle J.","family":"Hackney","sequence":"additional","affiliation":[{"name":"Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,12]]},"reference":[{"key":"ref001","unstructured":"Centers for Disease Control and Prevention. 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