{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:28:30Z","timestamp":1785536910231,"version":"3.56.0"},"reference-count":71,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2019,6,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Both low and high body mass index (BMI) have been associated with an increased risk of dementia, including that caused by Alzheimer\u2019s disease (AD). Specifically, high middle-age BMI or a low late-age BMI has been considered a predictor for the development of AD dementia. Less studied is the relationship between BMI and AD pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We explored the association between BMI and cortical amyloid-\u03b2 (A\u03b2) burden in cognitively normal participants that were either in mid-life (45\u201360 years) or late-life (&gt;60).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed cross-sectional baseline data from the Knight Alzheimer Disease Research Center (ADRC) at Washington University. A\u03b2 pathology was measured in 373 individuals with A\u03b2 PET imaging and was quantified using Centiloid units. We split the cohort into mid- and late-life groups for analyses ( n\u200a=\u200a96 and n\u200a=\u200a277, respectively). We ran general linear regression models to predict A\u03b2 levels from BMI while controlling for age, sex, years of education, and APOE4 status. Analyses were also conducted to test the interaction between BMI and APOE4 genotype and between BMI and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Higher BMI was associated with lower cortical A\u03b2 burden in late-life (\u03b2=\u200a\u20130.81, p\u200a=\u200a0.0066), but no relationship was found in mid-life (\u03b2=\u200a0.04, p\u200a&gt;\u200a0.5). The BMI\u00d7 APOE4+ and BMI\u00d7male interaction terms were not significant in the mid-life (\u03b2=\u200a0.28, p\u200a=\u200a0.41; \u03b2=\u200a0.64, p\u200a=\u200a0.13) or the late-life (\u03b2=\u200a0.17, p\u200a&gt;\u200a0.5; \u03b2=\u200a0.50, p\u200a=\u200a0.43) groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Higher late-life BMI is associated with lower cortical A\u03b2 burden in cognitively normal individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-190154","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T12:21:29Z","timestamp":1559046089000},"page":"817-827","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Higher Body Mass Index Is Associated with Lower Cortical Amyloid-\u03b2 Burden in Cognitively Normal Individuals in Late-Life"],"prefix":"10.1177","volume":"69","author":[{"given":"Vineeth","family":"Thirunavu","sequence":"first","affiliation":[{"name":"Department of Biology, Washington University in St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"McCullough","sequence":"additional","affiliation":[{"name":"Department of Radiology, Washington University in St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Su","sequence":"additional","affiliation":[{"name":"Banner Alzheimer\u2019s Institute, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaney","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Radiology, Washington University in St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Dincer","sequence":"additional","affiliation":[{"name":"Department of Radiology, Washington University in St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Knight Alzheimer Disease Research Center, Washington University in St. Louis, MO, USA"},{"name":"Department of Neurology, Washington University in St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cruchaga","sequence":"additional","affiliation":[{"name":"Knight Alzheimer Disease Research Center, Washington University in St. Louis, MO, USA"},{"name":"Department of Psychiatry, Washington University in St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie L.S.","family":"Benzinger","sequence":"additional","affiliation":[{"name":"Department of Radiology, Washington University in St. Louis, MO, USA"},{"name":"Knight Alzheimer Disease Research Center, Washington University in St. Louis, MO, 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