{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:53:16Z","timestamp":1782906796771,"version":"3.54.5"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2019,5,21]]},"DOI":"10.3233\/jad-190160","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T11:03:41Z","timestamp":1557831821000},"page":"413-421","source":"Crossref","is-referenced-by-count":15,"title":["Association between Sleep Disturbances and Medial Temporal Lobe Volume in Older Adults with Mild Cognitive Impairment Free of Lifetime History of Depression"],"prefix":"10.1177","volume":"69","author":[{"given":"Kimberley","family":"Yuen","sequence":"first","affiliation":[{"name":"Rotman Research Institute, Baycrest Health Sciences, North York, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the PACt-MD Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Rashidi-Ranjbar","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas Paul L.G.","family":"Verhoeff","sequence":"additional","affiliation":[{"name":"Baycrest Health Sciences Department of Psychiatry, North York, Ontario, Canada"},{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"},{"name":"Sunnybrook Health Sciences, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair J.","family":"Flint","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"},{"name":"University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"},{"name":"Sunnybrook Health Sciences, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce G.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit H.","family":"Mulsant","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek K.","family":"Rajji","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristotle N.","family":"Voineskos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"},{"name":"Centre for Addiction and Mental Health, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne E.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"},{"name":"Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Mah","sequence":"additional","affiliation":[{"name":"Rotman Research Institute, Baycrest Health Sciences, North York, Ontario, Canada"},{"name":"Baycrest Health Sciences Department of Psychiatry, North York, Ontario, Canada"},{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-190160_ref1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190160_ref2","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.neuroimage.2008.10.031","article-title":"Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: Results from ADNI","volume":"44","author":"Misra","year":"2009","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-190160_ref3","first-page":"491","article-title":"Medial temporal lobe atrophy predicts Alzheimer\u2019s disease in patients with minor cognitive impairment","volume":"72","author":"Visser","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-190160_ref4","first-page":"86","article-title":"Neuropsychiatric symptoms in amnestic mild cognitive impairment: Increased risk and faster progression to dementia","volume":"10","author":"Somme","year":"2013","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-190160_ref5","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.2147\/NDT.S47133","article-title":"Behavioral symptoms related to cognitive impairment","volume":"9","author":"Dillon","year":"2013","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.3233\/JAD-190160_ref6","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archpsyc.63.5.530","article-title":"Depression and risk for Alzheimer disease: Systematic review, meta-analysis, and metaregression analysis","volume":"63","author":"Ownby","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.3233\/JAD-190160_ref7","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jagp.2014.10.005","article-title":"Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease","volume":"23","author":"Mah","year":"2015","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-190160_ref8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3233\/JAD-2009-1120","article-title":"A systematic review of neuropsychiatric symptoms in mild cognitive impairment","volume":"18","author":"Monastero","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-190160_ref9","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2174\/1567205013666160502123129","article-title":"Neuropsychiatric disturbances in mild cognitive impairment (MCI): A systematic review of population-based studies","volume":"13","author":"Kohler","year":"2016","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-190160_ref10","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1212\/WNL.48.5_Suppl_6.10S","article-title":"The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients","volume":"48","author":"Cummings","year":"1997","journal-title":"Neurology"},{"key":"10.3233\/JAD-190160_ref11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1176\/jnp.12.2.233","article-title":"Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory","volume":"12","author":"Kaufer","year":"2000","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.3233\/JAD-190160_ref12","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia","volume":"44","author":"Cummings","year":"1994","journal-title":"Neurology"},{"key":"10.3233\/JAD-190160_ref13","first-page":"1","article-title":"Mild behavioural impairment: The early diagnosis","volume":"15","author":"Taragano","year":"2003","journal-title":"Int Psychogeriatr"},{"key":"10.3233\/JAD-190160_ref14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jalz.2015.05.017","article-title":"Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment","volume":"12","author":"Ismail","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190160_ref15","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1001\/archneur.64.8.1130","article-title":"Patterns of atrophy differ among specific subtypes of mild cognitive impairment","volume":"64","author":"Whitwell","year":"2007","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-190160_ref16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jns.2011.12.011","article-title":"Gray matter atrophy patterns of mild cognitive impairment subtypes","volume":"315","author":"Zhang","year":"2012","journal-title":"J Neurol Sci"},{"key":"10.3233\/JAD-190160_ref17","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.neuro.27.070203.144130","article-title":"The medial temporal lobe","volume":"27","author":"Squire","year":"2004","journal-title":"Annu Rev Neurosci"},{"key":"10.3233\/JAD-190160_ref18","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.biopsych.2011.12.024","article-title":"Depressive symptoms in mild cognitive impairment predict greater atrophy in Alzheimer\u2019s disease-related regions","volume":"71","author":"Lee","year":"2012","journal-title":"Biol Psychiatry"},{"key":"10.3233\/JAD-190160_ref19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1176\/appi.neuropsych.15100378","article-title":"Cortical thickness and anxiety symptoms among cognitively normal elderly persons: The Mayo Clinic Study of Aging","volume":"29","author":"Pink","year":"2017","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.3233\/JAD-190160_ref20","first-page":"41","article-title":"A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder","volume":"34","author":"McKinnon","year":"2009","journal-title":"J Psychiatry Neurosci"},{"key":"10.3233\/JAD-190160_ref21","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/hipo.20102","article-title":"Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: A meta-analysis of structural MRI studies","volume":"15","author":"Smith","year":"2005","journal-title":"Hippocampus"},{"key":"10.3233\/JAD-190160_ref22","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3233\/JAD-142931","article-title":"Lifetime history of depression predicts increased amyloid-beta accumulation in patients with mild cognitive impairment","volume":"45","author":"Chung","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-190160_ref23","volume-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I\/P).","author":"First","year":"2002"},{"key":"10.3233\/JAD-190160_ref24","volume-title":"Diagnostic and statistical manual of mental disorders. 5th ed.","author":"APA","year":"2013"},{"key":"10.3233\/JAD-190160_ref25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"10.3233\/JAD-190160_ref26","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-190160_ref27","doi-asserted-by":"crossref","first-page":"767","DOI":"10.2174\/15672050113109990134","article-title":"Sleep disturbance is associated with incident dementia and mortality","volume":"10","author":"Sterniczuk","year":"2013","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-190160_ref28","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1017\/S1041610209009120","article-title":"Sleep disturbances in older adults with mild cognitive impairment","volume":"21","author":"Beaulieu-Bonneau","year":"2009","journal-title":"Int Psychogeriatr"},{"key":"10.3233\/JAD-190160_ref29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1532-5415.2010.03288.x","article-title":"Greater risk of Alzheimer\u2019s disease in older adults with insomnia","volume":"59","author":"Osorio","year":"2011","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.3233\/JAD-190160_ref30","first-page":"613","article-title":"Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women","volume":"306","author":"Yaffe","year":"2011","journal-title":"JAMA"},{"key":"10.3233\/JAD-190160_ref31","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.tins.2016.05.002","article-title":"Sleep: A novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer\u2019s disease?","volume":"39","author":"Mander","year":"2016","journal-title":"Trends Neurosci"},{"key":"10.3233\/JAD-190160_ref32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neurobiolaging.2016.02.009","article-title":"Relationships between sleep quality and brain volume, metabolism, and amyloid deposition in late adulthood","volume":"41","author":"Branger","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-190160_ref33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jalz.2005.06.003","article-title":"Ways toward an early diagnosis in Alzheimer\u2019s disease: The Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI)","volume":"1","author":"Mueller","year":"2005","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190160_ref34","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1111\/j.1467-789X.2010.00825.x","article-title":"Body mass index in midlife and late-life as a risk factor for dementia: A meta-analysis of prospective studies","volume":"12","author":"Anstey","year":"2011","journal-title":"Obes Rev"},{"key":"10.3233\/JAD-190160_ref35","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1017\/S1355617709090638","article-title":"Profile of hippocampal volumes and stroke risk varies by neuropsychological definition of mild cognitive impairment","volume":"15","author":"Jak","year":"2009","journal-title":"J Int Neuropsychol Soc"},{"key":"10.3233\/JAD-190160_ref36","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1001\/archneur.65.12.1621","article-title":"Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes","volume":"65","author":"Kantarci","year":"2008","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-190160_ref37","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1001\/archneur.62.9.1393","article-title":"Differential cortical atrophy in subgroups of mild cognitive impairment","volume":"62","author":"Bell-McGinty","year":"2005","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-190160_ref38","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1212\/01.wnl.0000280575.77437.a2","article-title":"MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment","volume":"70","author":"Whitwell","year":"2008","journal-title":"Neurology"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-190160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:39Z","timestamp":1777370979000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-190160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,21]]},"references-count":38,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-190160","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,21]]}}}