{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:08:29Z","timestamp":1784380109511,"version":"3.55.0"},"reference-count":47,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2019,11,12]]},"DOI":"10.3233\/jad-190196","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T12:21:28Z","timestamp":1570191688000},"page":"641-652","source":"Crossref","is-referenced-by-count":14,"title":["Tau and Amyloid-\u03b2 Pathology in Japanese Forensic Autopsy Series Under 40 Years of Age: Prevalence and Association with APOE Genotype and Suicide Risk"],"prefix":"10.1177","volume":"72","author":[{"given":"Koji","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Neurology, Hyogo Brain and Heart Center, Hyogo, Japan"},{"name":"Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shojiro","family":"Ichimata","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-190196_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: A practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-190196_ref2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-190196_ref3","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A\u03b2-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"key":"10.3233\/JAD-190196_ref4","doi-asserted-by":"crossref","first-page":"a006189","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.3233\/JAD-190196_ref5","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1212\/01.WNL.0000115115.98960.37","article-title":"Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain","volume":"62","author":"Ingelsson","year":"2004","journal-title":"Neurology"},{"key":"10.3233\/JAD-190196_ref6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer\u2019s disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"10.3233\/JAD-190196_ref7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-190196_ref8","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00005072-199710000-00002","article-title":"Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease","volume":"56","author":"Hyman","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-190196_ref9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2990.1990.tb00940.x","article-title":"A quantitative histological study of early clinical and preclinical Alzheimer\u2019s disease","volume":"16","author":"Hubbard","year":"1990","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.3233\/JAD-190196_ref10","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jalz.2016.02.002","article-title":"Preclinical Alzheimer\u2019s disease: Definition, natural history, and diagnostic criteria","volume":"12","author":"Dubois","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190196_ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimers Dement"},{"issue":"Suppl 1","key":"10.3233\/JAD-190196_ref12","first-page":"S155","article-title":"Evolutional aspects of Alzheimer\u2019s disease pathogenesis","volume":"33","author":"Braak","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-190196_ref13","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1093\/brain\/awv236","article-title":"The preclinical phase of the pathological process underlying sporadic Alzheimer\u2019s disease","volume":"138","author":"Braak","year":"2015","journal-title":"Brain"},{"key":"10.3233\/JAD-190196_ref14","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: Age categories from 1 to 100 years","volume":"70","author":"Braak","year":"2011","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-190196_ref15","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jalz.2011.05.2410","article-title":"Neuropsychiatric symptoms in Alzheimer\u2019s disease","volume":"7","author":"Lyketsos","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190196_ref16","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1212\/WNL.0000000000003916","article-title":"Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease","volume":"88","author":"Ng","year":"2017","journal-title":"Neurology"},{"key":"10.3233\/JAD-190196_ref17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/gps.4489","article-title":"Amyloid burden and incident depressive symptoms in cognitively normal older adults","volume":"32","author":"Harrington","year":"2017","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-190196_ref18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0278-5846(02)00338-X","article-title":"Role of selective serotonin reuptake inhibitors in psychiatric disorders: A comprehensive review","volume":"27","author":"Vaswani","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.3233\/JAD-190196_ref19","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/nan.12229","article-title":"Pathological features of preclinical or early clinical stages of corticobasal degeneration: A comparison with advanced cases","volume":"41","author":"Nishida","year":"2015","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.3233\/JAD-190196_ref20","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00401-016-1665-7","article-title":"Incipient progressive supranuclear palsy is more common than expected and may comprise clinicopathological subtypes: A forensic autopsy series","volume":"133","author":"Yoshida","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-190196_ref21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/NEN.0000000000000184","article-title":"Neuropathologic features of suicide victims who presented with acute poststroke depression: Significance of association with neurodegenerative disorders","volume":"74","author":"Nishida","year":"2015","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-190196_ref22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/JGP.0b013e3181f61ae8","article-title":"The moderating effect of the APOE \u025b4 allele on the relationship between hippocampal volume and cognitive decline in older depressed patients","volume":"19","author":"Sachs-Ericsson","year":"2011","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-190196_ref23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-011-0906-z","article-title":"Hyperphosphorylated tau in young and middle-aged subjects","volume":"123","author":"Elobeid","year":"2012","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-190196_ref24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00401-015-1507-z","article-title":"Propagation of tau pathology: Hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies","volume":"131","author":"Lewis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-190196_ref25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00401-010-0789-4","article-title":"The pathological process underlying Alzheimer\u2019s disease in individuals under thirty","volume":"121","author":"Braak","year":"2011","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-190196_ref26","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1083\/jcb.200108057","article-title":"Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress","volume":"156","author":"Stamer","year":"2002","journal-title":"J Cell Biol"},{"key":"10.3233\/JAD-190196_ref27","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1074\/jbc.M114.589309","article-title":"Conformation determines the seeding potencies of native and recombinant Tau aggregates","volume":"290","author":"Falcon","year":"2015","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-190196_ref28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000283478","article-title":"Transition of tau protein from disordered to misordered in Alzheimer\u2019s disease","volume":"7","author":"Kovacech","year":"2010","journal-title":"Neurodegener Dis"},{"key":"10.3233\/JAD-190196_ref29","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1093\/brain\/awx046","article-title":"Association between tau deposition and antecedent amyloid-beta accumulation rates in normal and early symptomatic individuals","volume":"140","author":"Tosun","year":"2017","journal-title":"Brain"},{"key":"10.3233\/JAD-190196_ref30","doi-asserted-by":"crossref","first-page":"a011460","DOI":"10.1101\/cshperspect.a011460","article-title":"Deciphering Alzheimer disease","volume":"2","author":"Selkoe","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.3233\/JAD-190196_ref31","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S0197-4580(97)00064-X","article-title":"Neuropathological criteria for the diagnosis of Alzheimer\u2019s disease","volume":"18","author":"Markesbery","year":"1997","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-190196_ref32","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.neuroimage.2008.05.012","article-title":"Antemortem MRI based STructural Abnormality iNDex (STAND)-scores correlate with postmortem Braak neurofibrillary tangle stage","volume":"42","author":"Vemuri","year":"2008","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-190196_ref33","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X","article-title":"Tangles and plaques in nondemented aging and \u201cpreclinical\u201d Alzheimer\u2019s disease","volume":"45","author":"Price","year":"1999","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-190196_ref34","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neurobiolaging.2018.07.007","article-title":"The spectrum of preclinical Alzheimer\u2019s disease pathology and its modulation by ApoE genotype","volume":"71","author":"Pletnikova","year":"2018","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-190196_ref35","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/mp.2011.52","article-title":"APOE and Alzheimer disease: A major gene with semi-dominant inheritance","volume":"16","author":"Genin","year":"2011","journal-title":"Mol Psychiatry"},{"key":"10.3233\/JAD-190196_ref36","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature"},{"key":"10.3233\/JAD-190196_ref37","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jad.2018.10.115","article-title":"Mental disorders as risk factors for suicidal behavior in young people: A meta-analysis and systematic review of longitudinal studies","volume":"245","author":"Gili","year":"2019","journal-title":"J Affect Disord"},{"key":"10.3233\/JAD-190196_ref38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neurobiolaging.2017.04.004","article-title":"Neuropsychological measures that detect early impairment and decline in preclinical Alzheimer disease","volume":"56","author":"Schindler","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-190196_ref39","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jad.2015.11.008","article-title":"Geographical and temporal variations in the prevalence of mental disorders in suicide: Systematic review and meta-analysis","volume":"190","author":"Cho","year":"2016","journal-title":"J Affect Disord"},{"key":"10.3233\/JAD-190196_ref40","volume-title":"In The Neurobiological Basis of Suicide,","author":"Chandley","year":"2012"},{"key":"10.3233\/JAD-190196_ref41","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/nan.12386","article-title":"Locus coeruleus at asymptomatic early and middle Braak stages of neurofibrillary tangle pathology","volume":"43","author":"Andres-Benito","year":"2017","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.3233\/JAD-190196_ref42","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3233\/JAD-170001","article-title":"Depressive symptoms and tau accumulation in the inferior temporal lobe and entorhinal cortex in cognitively normal older adults: A pilot study","volume":"59","author":"Gatchel","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-190196_ref43","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jad.2017.12.101","article-title":"Amyloid burden and incident depressive symptoms in preclinical Alzheimer\u2019s disease","volume":"229","author":"Perin","year":"2018","journal-title":"J Affect Disord"},{"key":"10.3233\/JAD-190196_ref44","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/JGP.0b013e3181987730","article-title":"Depression, cognition, apolipoprotein e genotype: Latent class approach to identifying subtype","volume":"17","author":"Bogner","year":"2009","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.3233\/JAD-190196_ref45","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000095599","article-title":"Association of APOE genetic polymorphism with cognitive function and suicide history in geriatric depression","volume":"22","author":"Hwang","year":"2006","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-190196_ref46","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-015-1509-x","article-title":"Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy","volume":"131","author":"Kovacs","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-190196_ref47","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ajmg.b.32499","article-title":"Genomic variants, genes, and pathways of Alzheimer\u2019s disease: An overview","volume":"174","author":"Naj","year":"2017","journal-title":"Am J Med Genet B Neuropsychiatr Genet"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-190196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:06:55Z","timestamp":1777370815000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-190196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":47,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-190196","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]}}}