{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:04:44Z","timestamp":1787025884098,"version":"build-2736575974"},"reference-count":67,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2019,8,20]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      <jats:sup>18<\/jats:sup>\n                      F-Fluorodeoxyglucose (\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG) positron emission tomography (PET) and\n                      <jats:sup>18<\/jats:sup>\n                      F-florbetapir PET are approved neuroimaging biomarkers for the Alzheimer\u2019s disease (AD) and mild cognitive impairment (MCI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      This study aims to compare the efficacy of\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG and\n                      <jats:sup>18<\/jats:sup>\n                      F-florbetapir PET at evaluating the cognitive performance of patients with AD, MCI, and normal controls (NC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      63 subjects (36 male\/27 female, mean age\u200a=\u200a68.3) including 19 AD, 23 MCI, and 21 NC underwent\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG and\n                      <jats:sup>18<\/jats:sup>\n                      F-florbetapir PET imaging. A global quantification approach was applied on supra-tentorial, frontal, parieto-occipital, temporal, and cerebellar brain regions by calculating the global SUVmean ratios (GSUVr) as the weighted average of all regional SUVmean.\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG and\n                      <jats:sup>18<\/jats:sup>\n                      F-florbetapir GSUVr of each region were subsequently correlated with the Mini-Mental State Examination (MMSE).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Subjects were studied in five categories as NC, MCI patients, AD patients, MCI and AD patients grouped together (MCI\/AD), and a group including all the subjects (NC\/MCI\/AD). Both\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG and\n                      <jats:sup>18<\/jats:sup>\n                      F-florbetapir could successfully detect subjects with dementia ( p\u200a&lt;\u200a0.001). Studied in all regions and groups, the correlation analysis of\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG GSUVr with MMSE scores was significant in more regions and groups compared to that of\n                      <jats:sup>18<\/jats:sup>\n                      F-florbetapir. We also demonstrated that the correlation of\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG GSUVr with MMSE is stronger than that of\n                      <jats:sup>18<\/jats:sup>\n                      F-florbetapir in the supra-tentorial and temporal regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      This study reveals how\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG-PET global quantification is a superior indicator of cognitive performance in AD and MCI patients compared to\n                      <jats:sup>18<\/jats:sup>\n                      F-florbetapir PET. Accordingly, we still recommend\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG-PET over amyloid imaging in the evaluation for AD and MCI.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-190220","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T11:31:00Z","timestamp":1563276660000},"page":"1197-1207","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":65,"title":["<sup>18<\/sup>\n                    F-FDG Is a Superior Indicator of Cognitive Performance Compared to\n                    <sup>18<\/sup>\n                    F-Florbetapir in Alzheimer\u2019s Disease and Mild Cognitive Impairment Evaluation: A\u00a0Global Quantitative Analysis"],"prefix":"10.1177","volume":"70","author":[{"given":"Mohsen","family":"Khosravi","sequence":"first","affiliation":[{"name":"Department of Radiology, Thomas Jefferson University, 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