{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:01:25Z","timestamp":1777395685573,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2019,9,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although cerebral microbleeds (CMBs) are commonly observed in patients with Alzheimer\u2019s disease (AD), their clinical relevance for AD remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We investigated the significance of CMBs in AD by examining the relationship between CMBs and cerebral blood flow (CBF) in patients with AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty-four patients (aged 77.9\u00b17.6 years; 17 men) with probable AD and multiple (\u22658) CMBs were selected from 394 consecutive patients. For each lobe of the brain, the correlation between the number of CMBs observed on susceptibility-weighted images and the decrease in CBF observed on single-photon emission computed tomography was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The number of microbleeds was significantly correlated with the severity of decrease in the occipital lobe (Spearman\u2019s r\u200a=\u200a0.531, p\u200a&lt;\u200a0.001) and temporal lobe ( r\u200a=\u200a0.437, p\u200a&lt;\u200a0.001) but not in the frontal lobe ( r\u200a=\u200a0.201, p\u200a=\u200a0.101) and parietal lobe ( r\u200a=\u200a0.178, p\u200a=\u200a0.146). These results were unchanged in the partial correlational analysis after controlling the effect of other small vessel disease such as lacunars and white matter hyperintensities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Multiple CMBs are associated with cerebral hypoperfusion in AD. The effects of CMBs on CBF differed according to brain location, possibly reflecting different distributions of the underlying cerebral amyloid angiopathy and AD-related histopathology, such as neurofibrillary tangles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-190272","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T12:27:48Z","timestamp":1564144068000},"page":"273-280","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Cerebral Microbleeds Are Associated with Cerebral Hypoperfusion in Patients with Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"71","author":[{"given":"Yutaka","family":"Hatada","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Heisei Hospital, Yatsushiro, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohisa","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Kumamoto University Hospital, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Kumamoto University Hospital, Kumamoto, 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