{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:11:28Z","timestamp":1790878288492,"version":"4.1.0"},"reference-count":74,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2019,11,12]]},"DOI":"10.3233\/jad-190298","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T14:08:19Z","timestamp":1569938899000},"page":"479-494","source":"Crossref","is-referenced-by-count":103,"title":["Porphyromonas gingivalis Infection Induces Amyloid-\u03b2 Accumulation in Monocytes\/Macrophages"],"prefix":"10.1177","volume":"72","author":[{"given":"Ran","family":"Nie","sequence":"first","affiliation":[{"name":"Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan"},{"name":"OBT Research Center, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixian","family":"Yu","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gerontal Department of Stomatology, School and Hospital of Stomatology, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Kadowaki","sequence":"additional","affiliation":[{"name":"Division of Frontier Life Science, Department of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Kashiwazaki","sequence":"additional","affiliation":[{"name":"Section of Geriatric Dentistry and Perioperative Medicine in Dentistry, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Teeling","sequence":"additional","affiliation":[{"name":"Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dental Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-190298_ref1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrd2896","article-title":"Alzheimer\u2019s disease: strategies for disease modification","volume":"9","author":"Citron","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.3233\/JAD-190298_ref2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer\u2019s disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol Rev"},{"key":"10.3233\/JAD-190298_ref3","doi-asserted-by":"crossref","first-page":"11993","DOI":"10.1073\/pnas.91.25.11993","article-title":"Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation","volume":"91","author":"Citron","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-190298_ref4","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/jnr.10745","article-title":"Proteolytic processing of the Alzheimer\u2019s disease amyloid precursor protein in brain and platelets","volume":"74","author":"Evin","year":"2003","journal-title":"J Neurosci Res"},{"key":"10.3233\/JAD-190298_ref5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0002-9440(10)64947-4","article-title":"Elevated abeta42 in skeletal muscle of Alzheimer disease patients suggests peripheral alterations of AbetaPP metabolism","volume":"156","author":"Kuo","year":"2000","journal-title":"Am J Pathol"},{"key":"10.3233\/JAD-190298_ref6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jalz.2008.10.004","article-title":"Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer\u2019s disease","volume":"5","author":"Roher","year":"2009","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190298_ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/mp.2017.204","article-title":"Blood-derived amyloid-beta protein induces Alzheimer\u2019s disease pathologies","volume":"23","author":"Bu","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.3233\/JAD-190298_ref8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2174\/156720507780362245","article-title":"Role of the blood-brain barrier in the pathogenesis of Alzheimer\u2019s disease","volume":"4","author":"Deane","year":"2007","journal-title":"Curr Alzheimer Res"},{"key":"10.3233\/JAD-190298_ref9","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.neuropharm.2014.01.023","article-title":"Differences in amyloid-beta clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling","volume":"79","author":"Qosa","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.3233\/JAD-190298_ref10","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1084\/jem.20151428","article-title":"Rapid in vivo measurement of beta-amyloid reveals biphasic clearance kinetics in an Alzheimer\u2019s mouse model","volume":"213","author":"Yuede","year":"2016","journal-title":"J Exp Med"},{"key":"10.3233\/JAD-190298_ref11","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nn.3435","article-title":"CD33 Alzheimer\u2019s disease locus: altered monocyte function and amyloid biology","volume":"16","author":"Bradshaw","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.3233\/JAD-190298_ref12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbi.2014.05.003","article-title":"N-truncation and pyroglutaminylation enhances the opsonizing capacity of Abeta-peptides and facilitates phagocytosis by macrophages and microglia","volume":"41","author":"Condic","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.3233\/JAD-190298_ref13","doi-asserted-by":"crossref","first-page":"45897","DOI":"10.1074\/jbc.M407668200","article-title":"Systemic catabolism of Alzheimer\u2019s Abeta40 and Abeta42","volume":"279","author":"Ghiso","year":"2004","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-190298_ref14","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.3727\/096368915X688894","article-title":"Human umbilical cord blood-derived monocytes improve cognitive deficits and reduce amyloid-beta pathology in PSAPP mice","volume":"24","author":"Darlington","year":"2015","journal-title":"Cell Transplant"},{"key":"10.3233\/JAD-190298_ref15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3233\/JAD-2005-7304","article-title":"Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer\u2019s disease patients","volume":"7","author":"Fiala","year":"2005","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-190298_ref16","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1007\/s12035-016-9826-1","article-title":"Associations between hepatic functions and plasma amyloid-beta levels-implications for the capacity of liver in peripheral amyloid-beta clearance","volume":"54","author":"Wang","year":"2017","journal-title":"Mol Neurobiol"},{"key":"10.3233\/JAD-190298_ref17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jalz.2009.07.037","article-title":"Commentary on \u201cAlzheimer\u2019s disease drug development and the problem of the blood-brain barrier.\u201d Alzheimer\u2019s disease drugs: more than one barrier to breach","volume":"5","author":"Roher","year":"2009","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190298_ref18","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1002\/jnr.22603","article-title":"Peripheral reduction of beta-amyloid is sufficient to reduce brain beta-amyloid: implications for Alzheimer\u2019s disease","volume":"89","author":"Sutcliffe","year":"2011","journal-title":"J Neurosci Res"},{"key":"10.3233\/JAD-190298_ref19","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.jalz.2018.06.3040","article-title":"The antimicrobial protection hypothesis of Alzheimer\u2019s disease","volume":"14","author":"Moir","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190298_ref20","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature11060","article-title":"Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta","volume":"485","author":"Nussbaum","year":"2012","journal-title":"Nature"},{"key":"10.3233\/JAD-190298_ref21","doi-asserted-by":"crossref","first-page":"12393","DOI":"10.1021\/bi0612667","article-title":"On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)","volume":"45","author":"Schilling","year":"2006","journal-title":"Biochemistry"},{"key":"10.3233\/JAD-190298_ref22","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.1021\/bi900818a","article-title":"Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides","volume":"48","author":"Schlenzig","year":"2009","journal-title":"Biochemistry"},{"key":"10.3233\/JAD-190298_ref23","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.1074\/jbc.M110.185819","article-title":"Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate Abeta formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice","volume":"286","author":"Jawhar","year":"2011","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-190298_ref24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3233\/JAD-2011-110101","article-title":"The cysteine protease inhibitor, E64d, reduces brain amyloid-beta and improves memory deficits in Alzheimer\u2019s disease animal models by inhibiting cathepsin B, but not BACE1, beta-secretase activity","volume":"26","author":"Hook","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-190298_ref25","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1073\/pnas.97.4.1456","article-title":"Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein","volume":"97","author":"Lin","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.3233\/JAD-190298_ref26","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1074\/jbc.M109266200","article-title":"Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases","volume":"277","author":"Gruninger-Leitch","year":"2002","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-190298_ref27","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1515\/BC.2008.125","article-title":"Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases","volume":"389","author":"Bohme","year":"2008","journal-title":"Biol Chem"},{"key":"10.3233\/JAD-190298_ref28","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s11481-016-9721-6","article-title":"Cathepsin B improves \u03b2-amyloidosis and learning and memory in models of Alzheimer\u2019s disease","volume":"12","author":"Embury","year":"2017","journal-title":"J Neuroimmune Pharmacol"},{"key":"10.3233\/JAD-190298_ref29","doi-asserted-by":"crossref","first-page":"21071","DOI":"10.1074\/jbc.M117.811448","article-title":"A mechanistic model to predict effects of cathepsin B and cystatin C on beta-amyloid aggregation and degradation","volume":"292","author":"Perlenfein","year":"2017","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-190298_ref30","doi-asserted-by":"crossref","first-page":"11330","DOI":"10.1523\/JNEUROSCI.0677-12.2012","article-title":"Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain","volume":"32","author":"Sun","year":"2012","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-190298_ref31","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1016\/j.neurobiolaging.2013.05.018","article-title":"Differential pathways for interleukin-1beta production activated by chromogranin A and amyloid beta in microglia","volume":"34","author":"Wu","year":"2013","journal-title":"Neurobiol Aging"},{"issue":"Suppl 4","key":"10.3233\/JAD-190298_ref32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-0691.2007.01798.x","article-title":"Relationship between periodontal infections and systemic disease","volume":"13","author":"Seymour","year":"2007","journal-title":"Clin Microbiol Infect"},{"key":"10.3233\/JAD-190298_ref33","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-230X-12-16","article-title":"Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease","volume":"12","author":"Yoneda","year":"2012","journal-title":"BMC Gastroenterol"},{"key":"10.3233\/JAD-190298_ref34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00535-017-1368-4","article-title":"Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease","volume":"53","author":"Nakahara","year":"2018","journal-title":"J Gastroenterol"},{"key":"10.3233\/JAD-190298_ref35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3233\/JAD-2008-13408","article-title":"Alzheimer\u2019s disease and peripheral infections: the possible contribution from periodontal infections, model and hypothesis","volume":"13","author":"Kamer","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-190298_ref36","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3233\/JAD-121918","article-title":"Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer\u2019s disease brain tissue","volume":"36","author":"Poole","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-190298_ref37","doi-asserted-by":"crossref","first-page":"e0151081","DOI":"10.1371\/journal.pone.0151081","article-title":"Periodontitis and cognitive decline in Alzheimer\u2019s disease","volume":"11","author":"Ide","year":"2016","journal-title":"PLoS One"},{"key":"10.3233\/JAD-190298_ref38","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.bbi.2017.06.002","article-title":"Cathepsin B plays a critical role in inducing Alzheimer\u2019s disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice","volume":"65","author":"Wu","year":"2017","journal-title":"Brain Behav Immun"},{"key":"10.3233\/JAD-190298_ref39","doi-asserted-by":"crossref","first-page":"e0204941","DOI":"10.1371\/journal.pone.0204941","article-title":"Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice","volume":"13","author":"Ilievski","year":"2018","journal-title":"PLoS One"},{"issue":"Suppl 1","key":"10.3233\/JAD-190298_ref40","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1002\/JPER.17-0719","article-title":"Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Chapple","year":"2018","journal-title":"J Periodontol"},{"key":"10.3233\/JAD-190298_ref41","doi-asserted-by":"crossref","first-page":"12488","DOI":"10.1523\/JNEUROSCI.1599-15.2015","article-title":"The critical role of proteolytic relay through Cathepsins B and E in the phenotypic change of microglia\/macrophage","volume":"35","author":"Ni","year":"2015","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-190298_ref42","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/ni.2705","article-title":"Tissue-resident macrophages","volume":"14","author":"Davies","year":"2013","journal-title":"Nat Immunol"},{"key":"10.3233\/JAD-190298_ref43","doi-asserted-by":"crossref","first-page":"R1262","DOI":"10.1152\/ajpregu.00724.2005","article-title":"Kupffer cell-generated PGE2 triggers the febrile response of guinea pigs to intravenously injected LPS","volume":"290","author":"Li","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.3233\/JAD-190298_ref44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver\u2013from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.3233\/JAD-190298_ref45","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jalz.2011.04.006","article-title":"Serum antibodies to periodontal pathogens are a risk factor for Alzheimer\u2019s disease","volume":"8","author":"Sparks Stein","year":"2012","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190298_ref46","doi-asserted-by":"crossref","first-page":"8459","DOI":"10.3748\/wjg.v19.i46.8459","article-title":"Liver physiology and liver diseases in the elderly","volume":"19","author":"Tajiri","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.3233\/JAD-190298_ref47","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/cphy.c120026","article-title":"Kupffer cells in the liver","volume":"3","author":"Dixon","year":"2013","journal-title":"Compr Physiol"},{"key":"10.3233\/JAD-190298_ref48","doi-asserted-by":"crossref","first-page":"407562","DOI":"10.1155\/2013\/407562","article-title":"Leptomeningeal cells transduce peripheral macrophages inflammatory signal to microglia in response to Porphyromonas gingivalis LPS","volume":"2013","author":"Liu","year":"2013","journal-title":"Mediators Inflamm"},{"key":"10.3233\/JAD-190298_ref49","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1124\/mol.65.5.1092","article-title":"Nuclear factor-kappaB mediates up-regulation of cathepsin B by doxorubicin in tumor cells","volume":"65","author":"Bien","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.3233\/JAD-190298_ref50","doi-asserted-by":"crossref","first-page":"e0158629","DOI":"10.1371\/journal.pone.0158629","article-title":"Unprimed, M1 and M2 macrophages differentially interact with Porphyromonas gingivalis","volume":"11","author":"Lam","year":"2016","journal-title":"PLoS One"},{"key":"10.3233\/JAD-190298_ref51","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1465-9921-15-72","article-title":"Impaired macrophage phagocytosis of bacteria in severe asthma","volume":"15","author":"Liang","year":"2014","journal-title":"Respir Res"},{"key":"10.3233\/JAD-190298_ref52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000358430","article-title":"Pyroglutamate-amyloid-beta and glutaminyl cyclase are colocalized with amyloid-beta in secretory vesicles and undergo activity-dependent, regulated secretion","volume":"14","author":"Cynis","year":"2014","journal-title":"Neurodegener Dis"},{"key":"10.3233\/JAD-190298_ref53","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.drudis.2006.08.004","article-title":"Clearance of amyloid-beta in Alzheimer\u2019s disease: progress, problems and perspectives","volume":"11","author":"Wang","year":"2006","journal-title":"Drug Discov Today"},{"key":"10.3233\/JAD-190298_ref54","doi-asserted-by":"crossref","first-page":"14140","DOI":"10.1074\/jbc.270.23.14140","article-title":"Proteolytic processing of Alzheimer\u2019s disease beta A4 amyloid precursor protein in human platelets","volume":"270","author":"Li","year":"1995","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"10.3233\/JAD-190298_ref55","first-page":"20","article-title":"Disruption of pathologic amyloid beta-protein fibril assembly on the surface of cultured human cerebrovascular smooth muscle cells","volume":"8","author":"Van Nostrand","year":"2001","journal-title":"Amyloid"},{"key":"10.3233\/JAD-190298_ref56","doi-asserted-by":"crossref","first-page":"a006304","DOI":"10.1101\/cshperspect.a006304","article-title":"Presenilins and gamma-secretase: structure, function, and role in Alzheimer disease","volume":"2","author":"De Strooper","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.3233\/JAD-190298_ref57","doi-asserted-by":"crossref","first-page":"a004457","DOI":"10.1101\/cshperspect.a004457","article-title":"Alzheimer\u2019s disease","volume":"3","author":"Selkoe","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.3233\/JAD-190298_ref58","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/brain\/awn053","article-title":"Interrelation of inflammation and APP in sIBM: IL-1 beta induces accumulation of beta-amyloid in skeletal muscle","volume":"131","author":"Schmidt","year":"2008","journal-title":"Brain"},{"key":"10.3233\/JAD-190298_ref59","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1515\/BC.2008.124","article-title":"Alternative pathways for production of beta-amyloid peptides of Alzheimer\u2019s disease","volume":"389","author":"Hook","year":"2008","journal-title":"Biol Chem"},{"key":"10.3233\/JAD-190298_ref60","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1515\/BC.2008.025","article-title":"Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s)","volume":"389","author":"Schechter","year":"2008","journal-title":"Biol Chem"},{"key":"10.3233\/JAD-190298_ref61","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1515\/bc.2011.054","article-title":"Cathepsins S, B and L with aminopeptidases display beta-secretase activity associated with the pathogenesis of Alzheimer\u2019s disease","volume":"392","author":"Schechter","year":"2011","journal-title":"Biol Chem"},{"key":"10.3233\/JAD-190298_ref62","doi-asserted-by":"crossref","first-page":"e0182895","DOI":"10.1371\/journal.pone.0182895","article-title":"Abeta42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways","volume":"12","author":"Farizatto","year":"2017","journal-title":"PLoS One"},{"key":"10.3233\/JAD-190298_ref63","doi-asserted-by":"crossref","first-page":"7745","DOI":"10.1074\/jbc.M708362200","article-title":"Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein","volume":"283","author":"Hook","year":"2008","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-190298_ref64","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3233\/JAD-131370","article-title":"Brain pyroglutamate amyloid-beta is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer\u2019s disease therapeutic","volume":"41","author":"Hook","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-190298_ref65","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1006\/bbrc.2000.3490","article-title":"Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer\u2019s disease brain","volume":"276","author":"Harigaya","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-190298_ref66","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/bbrc.1997.7083","article-title":"Isolation, chemical characterization, and quantitation of A beta 3-pyroglutamyl peptide from neuritic plaques and vascular amyloid deposits","volume":"237","author":"Kuo","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/JAD-190298_ref67","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0896-6273(95)90301-1","article-title":"Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques","volume":"14","author":"Saido","year":"1995","journal-title":"Neuron"},{"key":"10.3233\/JAD-190298_ref68","doi-asserted-by":"crossref","first-page":"8154","DOI":"10.1074\/jbc.M111.308601","article-title":"Pyroglutamate amyloid beta (Abeta) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease","volume":"287","author":"Wittnam","year":"2012","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-190298_ref69","doi-asserted-by":"crossref","first-page":"12790","DOI":"10.1523\/JNEUROSCI.1794-11.2011","article-title":"Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Abeta is induced by pyroglutamate-Abeta formation","volume":"31","author":"Alexandru","year":"2011","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-190298_ref70","doi-asserted-by":"crossref","first-page":"34186","DOI":"10.1074\/jbc.M501694200","article-title":"beta-amyloid is different in normal aging and in Alzheimer disease","volume":"280","author":"Piccini","year":"2005","journal-title":"J Biol Chem"},{"key":"10.3233\/JAD-190298_ref71","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/(SICI)1097-0029(19971115)39:4<350::AID-JEMT5>3.0.CO;2-L","article-title":"Development, differentiation, and maturation of Kupffer cells","volume":"39","author":"Naito","year":"1997","journal-title":"Microsc Res Tech"},{"key":"10.3233\/JAD-190298_ref72","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1365-2958.2000.02103.x","article-title":"Salmonella induces macrophage death by caspase-1-dependent necrosis","volume":"38","author":"Brennan","year":"2000","journal-title":"Mol Microbiol"},{"key":"10.3233\/JAD-190298_ref73","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1038\/s41598-017-07196-7","article-title":"Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system","volume":"7","author":"Sato","year":"2017","journal-title":"Sci Rep"},{"key":"10.3233\/JAD-190298_ref74","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/oxfordjournals.jbchem.a135277","article-title":"Distribution of cathepsins B and H in rat tissues and peripheral blood cells","volume":"98","author":"Kominami","year":"1985","journal-title":"J Biochem"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-190298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:06:55Z","timestamp":1777370815000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-190298"}},"subtitle":[],"editor":[{"given":"Sim","family":"Singhrao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":74,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-190298","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]}}}