{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:42:10Z","timestamp":1790152930420,"version":"4.0.1"},"reference-count":61,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2019,7,23]]},"DOI":"10.3233\/jad-190385","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T11:57:40Z","timestamp":1559908660000},"page":"425-432","source":"Crossref","is-referenced-by-count":16,"title":["Somatosensory Temporal Discrimination Threshold in Patients with Cognitive Disorders"],"prefix":"10.1177","volume":"70","author":[{"given":"Fabrizia","family":"D\u2019Antonio","sequence":"first","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome Italy"},{"name":"PhD Program in Behavioral Neuroscience, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ilenia","family":"De Bartolo","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Ferrazzano","sequence":"additional","affiliation":[{"name":"IRCCS Neuromed, Pozzilli (IS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Trebbastoni","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Amicarelli","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Campanelli","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"de Lena","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Berardelli","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome Italy"},{"name":"IRCCS Neuromed, Pozzilli (IS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience, Sapienza University of Rome, Rome Italy"},{"name":"IRCCS Neuromed, Pozzilli (IS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-190385_ref1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/brain\/115.1.199","article-title":"Temporal discrimination is abnormal in parkinson\u2019s disease","volume":"115","author":"Artieda","year":"1992","journal-title":"Brain"},{"key":"10.3233\/JAD-190385_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4115(96)80050-1","article-title":"Neurophysiological mechanisms of temporal perception","volume":"115","author":"Artieda","year":"1996","journal-title":"Adv Psychol"},{"key":"10.3233\/JAD-190385_ref3","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1136\/jnnp.54.12.1077","article-title":"The anatomical basis of somaesthetic temporal","volume":"54","author":"Lacruz","year":"1991","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-190385_ref4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/036107300243605","article-title":"Estimation of short temporal intervals in alzheimer\u2019s disease","volume":"26","author":"Carrasco","year":"2000","journal-title":"Exp Aging Res"},{"key":"10.3233\/JAD-190385_ref5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0278-2626(03)00237-9","article-title":"Time estimation in Alzheimer\u2019s disease and the role of the central executive","volume":"54","author":"Papagno","year":"2004","journal-title":"Brain Cogn"},{"key":"10.3233\/JAD-190385_ref6","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1037\/a0014289","article-title":"Time estimation abilities in mild cognitive impairment and Alzheimer\u2019s disease","volume":"23","author":"Rueda","year":"2009","journal-title":"Neuropsychology"},{"key":"10.3233\/JAD-190385_ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1744-9081-5-32","article-title":"Time estimation in mild Alzheimer\u2019s disease patients","volume":"5","author":"Caselli","year":"2009","journal-title":"Behav Brain Funct"},{"key":"10.3233\/JAD-190385_ref8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bandc.2013.06.008","article-title":"Prospective and retrospective time perception are related to mental time travel: Evidence from Alzheimer\u2019s disease","volume":"83","author":"El Haj","year":"2013","journal-title":"Brain Cogn"},{"key":"10.3233\/JAD-190385_ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bandc.2014.04.002","article-title":"Time reproduction during high and low attentional tasks in Alzheimer\u2019s Disease \u201cA watched kettle never boils.\u201d","volume":"88","author":"El Haj","year":"2014","journal-title":"Brain Cogn"},{"key":"10.3233\/JAD-190385_ref10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0926-6410(93)90014-V","article-title":"Precision and accuracy of subjective time estimation in different memory disorders","volume":"1","author":"Nichelli","year":"1993","journal-title":"Cogn Brain Res"},{"key":"10.3233\/JAD-190385_ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/npjamd.2016.16","article-title":"Time distortions in Alzheimer\u2019s disease: A systematic review and theoretical integration","volume":"2","author":"El Haj","year":"2016","journal-title":"NPJ Aging Mech Dis"},{"key":"10.3233\/JAD-190385_ref12","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1017\/S1355617716000606","article-title":"Time perception in mild cognitive impairment: Interval length and subjective passage of time","volume":"22","author":"Coelho","year":"2016","journal-title":"J Int Neuropsychol Soc"},{"key":"10.3233\/JAD-190385_ref13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.conb.2004.03.013","article-title":"The neural representation of time","volume":"14","author":"Ivry","year":"2004","journal-title":"Curr Opin Neurobiol"},{"key":"10.3233\/JAD-190385_ref14","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0959-4388(96)80037-7","article-title":"The representation of temporal information in perception and motor control","volume":"6","author":"Ivry","year":"1996","journal-title":"Curr Opin Neurobiol"},{"key":"10.3233\/JAD-190385_ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0032979","article-title":"Theta-burst stimulation-induced plasticity over primary somatosensory cortex changes somatosensory temporal discrimination in healthy humans","volume":"7","author":"Conte","year":"2012","journal-title":"PLoS One"},{"key":"10.3233\/JAD-190385_ref16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1523\/JNEUROSCI.2008-15.2016","article-title":"Somatosensory temporal discrimination threshold involves inhibitory mechanisms in the primary somatosensory area","volume":"36","author":"Rocchi","year":"2016","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-190385_ref17","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1523\/JNEUROSCI.4210-03.2004","article-title":"The functional neuroanatomy of temporal discrimination","volume":"24","author":"Pastor","year":"2004","journal-title":"J Neurosci"},{"key":"10.3233\/JAD-190385_ref18","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1016\/j.neuropsychologia.2012.08.011","article-title":"Subjective cognitive complaints and amyloid burden in cognitively normal older individuals","volume":"50","author":"Amariglio","year":"2012","journal-title":"Neuropsychologia"},{"key":"10.3233\/JAD-190385_ref19","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jalz.2014.01.001","article-title":"A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer\u2019s disease","volume":"10","author":"Jessen","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190385_ref20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190385_ref21","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190385_ref22","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jalz.2016.09.012","article-title":"Implementation of subjective cognitive decline criteria in research studies","volume":"13","author":"Molinuevo","year":"2017","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-190385_ref23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/brain\/awn298","article-title":"Medial temporal lobe atrophy on MRI differentiates Alzheimer\u2019s disease from dementia with Lewy bodies and vascular cognitive impairment: A prospective study with pathological verification of diagnosis","volume":"132","author":"Burton","year":"2009","journal-title":"Brain"},{"key":"10.3233\/JAD-190385_ref24","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular dementia: Diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop","volume":"43","author":"Roman","year":"1993","journal-title":"Neurology"},{"key":"10.3233\/JAD-190385_ref25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.3233\/JAD-190385_ref26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of older people: Self-maintaining and instrumental activities of daily living","volume":"9","author":"Lawton","year":"1969","journal-title":"Gerontologist"},{"key":"10.3233\/JAD-190385_ref27","first-page":"1","article-title":"Normative data of two memory tasks: Short-Story recall and Rey\u2019s Figure","volume":"12","author":"Carlesimo","year":"2002","journal-title":"Nuova Riv Neurol"},{"key":"10.3233\/JAD-190385_ref28","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF02333660","article-title":"Verbal and spatial immediate memory span: Normative data from 1355 adults and 1112 children","volume":"8","author":"Orsini","year":"1987","journal-title":"Ital J Neurol Sci"},{"key":"10.3233\/JAD-190385_ref30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF01997792","article-title":"Trail Making Test: Normative values from 287 normal adult controls","volume":"17","author":"Giovagnoli","year":"1996","journal-title":"Ital J Neurol Sci"},{"key":"10.3233\/JAD-190385_ref31","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1080\/01688638608405189","article-title":"Normative data on the Boston Naming Test for group of normal older adults","volume":"8","author":"van Gorp","year":"1986","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.3233\/JAD-190385_ref32","first-page":"477","article-title":"Tre test clinici di ricerca e produzione lessicale. Taratura su soggetti normali","volume":"47","author":"Novelli","year":"1986","journal-title":"Arch Psicol Neurol Psichiatr"},{"key":"10.3233\/JAD-190385_ref33","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/gps.930080606","article-title":"Clock-drawing and dementia in the community: A longitudinal study","volume":"8","author":"Shulman","year":"1993","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.3233\/JAD-190385_ref34","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s10072-005-0443-4","article-title":"The Frontal Assessment Battery (FAB): Normative values in an Italian population sample","volume":"26","author":"Appollonio","year":"2005","journal-title":"Neurol Sci"},{"key":"10.3233\/JAD-190385_ref35","first-page":"189","article-title":"Raven\u2019s Coloured Progressive Matrices: Normative values on 305 adult normal controls","volume":"2","author":"Basso","year":"1987","journal-title":"Funct Neurol"},{"key":"10.3233\/JAD-190385_ref36","unstructured":"Raven JC , (Firm) HKL (1958) Standard progressive matrices: Sets A, B, C, D and E. H.K. Lewis, London."},{"key":"10.3233\/JAD-190385_ref37","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1016\/j.clinph.2016.06.026","article-title":"Somatosensory temporal discrimination threshold in Parkinson\u2019s disease parallels disease severity and duration","volume":"127","author":"Conte","year":"2016","journal-title":"Clin Neurophysiol"},{"key":"10.3233\/JAD-190385_ref38","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.clinph.2017.11.022","article-title":"Abnormal somatosensory temporal discrimination in Parkinson\u2019s disease: Pathophysiological correlates and role in motor control deficits","volume":"129","author":"Lee","year":"2018","journal-title":"Clin Neurophysiol"},{"key":"10.3233\/JAD-190385_ref39","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1093\/brain\/awq191","article-title":"Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinson\u2019s disease","volume":"133","author":"Conte","year":"2010","journal-title":"Brain"},{"key":"10.3233\/JAD-190385_ref40","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.clinph.2013.08.006","article-title":"Primary somatosensory cortical plasticity and tactile temporal discrimination in focal hand dystonia","volume":"125","author":"Conte","year":"2014","journal-title":"Clin Neurophysiol"},{"key":"10.3233\/JAD-190385_ref41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3389\/fneur.2017.00249","article-title":"Abnormal temporal coupling of tactile perception and motor action in Parkinson\u2019s disease","volume":"8","author":"Conte","year":"2017","journal-title":"Front Neurol"},{"key":"10.3233\/JAD-190385_ref42","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neurobiolaging.2016.04.009","article-title":"Temporal discrimination threshold with healthy aging","volume":"43","author":"Ramos","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-190385_ref43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neuroimage.2008.01.034","article-title":"Putaminal activity is related to perceptual certainty","volume":"41","author":"Pastor","year":"2008","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-190385_ref44","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-190385_ref45","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cogbrainres.2004.01.010","article-title":"Neural representation of interval encoding and decision making","volume":"21","author":"Harrington","year":"2004","journal-title":"Cogn Brain Res"},{"key":"10.3233\/JAD-190385_ref46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0301-0082(02)00011-4","article-title":"Dopamine and the regulation of cognition and attention","volume":"67","author":"Nieoullon","year":"2002","journal-title":"Prog Neurobiol"},{"key":"10.3233\/JAD-190385_ref47","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.neuroimage.2005.05.034","article-title":"A positron emission tomography (PET) investigation of the role of striatal dopamine (D2) receptor availability in spatial cognition","volume":"28","author":"Reeves","year":"2005","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-190385_ref48","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1093\/cercor\/bht345","article-title":"Selective attentional enhancement and inhibition of fronto-posterior connectivity by the basal ganglia during attention switching","volume":"25","author":"Van Schouwenburg","year":"2015","journal-title":"Cereb Cortex"},{"key":"10.3233\/JAD-190385_ref49","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1162\/jocn_a_00770","article-title":"Disentangling the role of cortico-basal ganglia loops in top-down and bottom-up visual attention: An investigation of attention deficits in Parkinson disease","volume":"27","author":"Tommasi","year":"2015","journal-title":"J Cogn Neurosci"},{"key":"10.3233\/JAD-190385_ref50","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1002\/hbm.22124","article-title":"The centre of the brain: Toographical model of motor, cognitive, affective, and somatosensory functions of the basal ganglia","volume":"34","author":"Arsalidou","year":"2013","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JAD-190385_ref51","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1080\/00207454.2017.1385614","article-title":"The dopaminergic system dynamic in the time perception: A review of the evidence","volume":"128","author":"Marinho","year":"2018","journal-title":"Int J Neurosci"},{"key":"10.3233\/JAD-190385_ref52","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.tics.2006.07.006","article-title":"Remembering the time: A continuous clock","volume":"10","author":"Lewis","year":"2006","journal-title":"Trends Cogn Sci"},{"key":"10.3233\/JAD-190385_ref53","first-page":"317","volume-title":"Functional and neural mechanisms of interval timing","author":"Buhusi","year":"2003"},{"key":"10.3233\/JAD-190385_ref54","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nn2024","article-title":"Prefrontal cortex and basal ganglia control access to working memory","volume":"11","author":"McNab","year":"2008","journal-title":"Nat Neurosci"},{"key":"10.3233\/JAD-190385_ref55","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.neubiorev.2009.05.005","article-title":"The dopaminergic basis of human behaviors: A review of molecular imaging studies","volume":"33","author":"Egerton","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"10.3233\/JAD-190385_ref56","doi-asserted-by":"crossref","first-page":"14727","DOI":"10.1038\/ncomms14727","article-title":"Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer\u2019s disease","volume":"8","author":"Nobili","year":"2017","journal-title":"Nat Commun"},{"key":"10.3233\/JAD-190385_ref57","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3233\/JAD-171018","article-title":"Volume and connectivity of the ventral tegmental area are linked to neurocognitive signatures of Alzheimer\u2019s disease in humans","volume":"63","author":"De Marco","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-190385_ref58","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1037\/0033-295X.84.3.279","article-title":"Scalar Expectancy Theory and Weber\u2019s Law in Animal Timing","volume":"84","author":"Gibbon","year":"1977","journal-title":"Psychol Rev"},{"key":"10.3233\/JAD-190385_ref59","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1749-6632.1984.tb23459.x","article-title":"Properties of the internal clock","volume":"423","author":"Church","year":"1984","journal-title":"Ann N Y Acad Sci"},{"key":"10.3233\/JAD-190385_ref60","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1126\/science.1091573","article-title":"Functional anatomy of the attentional modulation of time estimation","volume":"303","author":"Coull","year":"2004","journal-title":"Science"},{"key":"10.3233\/JAD-190385_ref61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/npp.2010.113","article-title":"Neuroanatomical and neurochemical substrates of timing","volume":"36","author":"Coull","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.3233\/JAD-190385_ref62","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/mds.21870","article-title":"Impaired intracortical inhibition in the primary somatosensory cortex in focal hand dystonia","volume":"23","author":"Tamura","year":"2008","journal-title":"Mov Disord"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-190385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:10:08Z","timestamp":1777371008000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JAD-190385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,23]]},"references-count":61,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jad-190385","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,23]]}}}