{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:08:23Z","timestamp":1792206503222,"version":"4.4.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Behavioral and psychological symptoms of dementia (BPSD) affect 60\u201390% of patients with Alzheimer\u2019s disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine if environmental therapy is an effective strategy to reduce BPSD, we tested 163 patients with AD with Neuropsychiatric Inventory (NPI) before and after 6 months of an indoor therapeutic garden (TG) or standard environment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A single-blind randomized controlled trial on AD patients with BPSD. Participants were randomized to an indoor TG (N\u200a=\u200a82), or standard environment (control, N\u200a=\u200a81) for 6 months. Primary outcome: change in the NPI score from baseline (T0) to end of treatment (T1). Secondary outcomes: change in use of quetiapine, cognition, activities of daily living, salivary cortisol, blood pressure from T0 to T1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>NPI score significantly ameliorated (TG versus control: \u201331.8 points), quetiapine dosage (\u2013150 mg), blood pressure (\u20132.6 mm Hg), and salivary cortisol (\u20136.4 to \u20132.1\u200aNmol\/l) were significantly reduced, the Mini-Mental State Examination significantly improved (1.8 points) in the TG versus control arm at T1 ( p\u200a&lt;\u200a0.001). No adverse events were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The indoor TG seems safe and may reduce BPSD, medication intake, and cortisol levels in AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-190394","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T11:34:40Z","timestamp":1565955280000},"page":"813-823","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":43,"title":["An Indoor Therapeutic Garden for Behavioral Symptoms in Alzheimer\u2019s Disease: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"71","author":[{"given":"Anna","family":"Pedrinolla","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Tamburin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Brasioli","sequence":"additional","affiliation":[{"name":"Monsignor Mazzali Foundation, Mantua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Sollima","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, University Health and Wealth of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fonte","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Muti","sequence":"additional","affiliation":[{"name":"Monsignor Mazzali Foundation, Mantua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Smania","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Schena","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Venturelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy"},{"name":"Department of Internal Medicine, University of Utah, Salt Lake City, UT, 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