{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:08:03Z","timestamp":1777396083014,"version":"3.51.4"},"reference-count":90,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,2,18]]},"abstract":"<jats:p>Auditory agnosia for environmental sounds (AES) is an example of central auditory dysfunction. It is presumed to be independent of language deficits and in presence of normal hearing. We undertook a detailed neuropsychological assessment including environmental sound naming and recognition in 34 clinically mild Alzheimer\u2019s disease (AD) patients and 29 age-matched healthy control subjects. In patients with AD, audiometry was performed to assess the impact on test performance, and in normal controls the Hearing Handicap Inventory for the Elderly \u2013 Screening Version to exclude more than mild hearing loss. We adapted a validated environmental sound battery and found near perfect scores in controls. We found that environmental sound agnosia is common in mild AD. We found a statistically significant difference in mean pure tone audiometry in the best ear between patients with and those patients without naming deficits of 11.3\u200adB ( p\u200a=\u200a0.010) and of 14.7\u200adB ( p\u200a=\u200a0.000) between those with and without recognition deficits. Statistical significance remained after correcting for age, aphasia, Mini-Mental State Examination score, and working memory. Slight and moderate peripheral hearing loss increases the odds ratio of recognition deficits by 13.75 (confidence interval 2.3\u201381.5) compared to normal hearing patients. We did not find evidence for different forms of AES. This work suggests that an interaction between peripheral hearing loss and AD pathology produces problems with environmental sound recognition. It confirms that the relationship between hearing and dementia is complex but also suggests that interventions to prevent and treat hearing loss could have an effect on AD in its clinical expression.<\/jats:p>","DOI":"10.3233\/jad-190431","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T11:28:34Z","timestamp":1579001314000},"page":"1407-1419","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Auditory Agnosia for Environmental Sounds in Alzheimer\u2019s Disease: Not Hearing and Not Listening?"],"prefix":"10.1177","volume":"73","author":[{"given":"Jan A.F.","family":"Coebergh","sequence":"first","affiliation":[{"name":"Department of Neurology, HagaHospital, The Hague, The Netherlands"},{"name":"Department of Neurology, Ashford and St. Peter\u2019s Hospital, Chertsey, United Kingdom"},{"name":"Department of Neurology, St. George\u2019s Hospital, Tooting, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"McDowell","sequence":"additional","affiliation":[{"name":"Department of Neurology, HagaHospital, The Hague, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodorus C.A.M.","family":"van Woerkom","sequence":"additional","affiliation":[{"name":"Department of Neurology, HagaHospital, The Hague, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan P.","family":"Koopman","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat Surgery, HagaHospital, The Hague, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology, HagaHospital, The Hague, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiaan F.T.M.","family":"Bruijn","sequence":"additional","affiliation":[{"name":"Department of Neurology, HagaHospital, The Hague, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70736-6"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-62630-1.00032-9"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1177\/0013916587191005"},{"key":"ref004","volume-title":"Persistence and change. 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