{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:05:45Z","timestamp":1787753145031,"version":"build-2784847793"},"reference-count":69,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"<jats:p>With increased longevity and growth in the number of older adults comes rising rates of individuals with cognitive impairment and dementia. The expansion of this population has important implications for research on aging and dementia syndromes, namely increased enrollment of older individuals in clinical research. Ethical prerogatives, as well as historical underrepresentation of persons with dementia in research studies due to the perceived burden of traditional decisional capacity evaluations, necessitates the development of pragmatic approaches to ascertain decisional abilities in research settings. We outline a protocol used in the Wisconsin Alzheimer\u2019s Disease Research Center (ADRC) that adopts a stepped approach to the evaluation of decisional capacity meant to maximize study visit efficiency while preserving participant safety and autonomy. The protocol specifies the structure of the consent process and incorporates a brief semi-structured interview based on Appelbaum &amp; Grisso\u2019s theoretical model for evaluating a patient\u2019s decisional capacity to provide informed consent to participate in research. This protocol is easily implemented in a research study visit and is designed to minimize participant burden and ensure reliable assessment of decisional capacity in older adults across a wide range of research protocols. The protocol emphasizes capacity optimization, using memory aids and other compensatory strategies to preserve participant autonomy while protecting welfare.<\/jats:p>","DOI":"10.3233\/jad-190457","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T10:42:30Z","timestamp":1576579350000},"page":"431-442","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["The U-ARE Protocol: A Pragmatic Approach to Decisional Capacity Assessment for Clinical Research"],"prefix":"10.1177","volume":"73","author":[{"given":"Rachel K.B.","family":"Hamilton","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Wisconsin \u2013 Madison, Madison, WI, USA"},{"name":"Geriatric Research, Education, & Clinical Center, William S. 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Middleton Memorial Veterans Hospital, Madison, WI, USA"},{"name":"Department of Medicine \u2013 Division of Geriatrics, School of Medicine and Public Health, University of Wisconsin \u2013 Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nickolas","family":"Lambrou","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, & Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichelle","family":"Cobb","sequence":"additional","affiliation":[{"name":"Health Sciences IRBs Director, University of Wisconsin \u2013 Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy J.H.","family":"Kind","sequence":"additional","affiliation":[{"name":"Geriatric Research, Education, & Clinical Center, William S. 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