{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:01:40Z","timestamp":1791576100840,"version":"4.3.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"<jats:p>Despite extensive research, the origin of Alzheimer\u2019s disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases the risk of developing AD. We hypothesized that H. pylori-induced gastritis may be associated with a systemic inflammation and finally neuroinflammation. C57BL\/6 mice were infected with H. pylori ( n\u200a=\u200a15) or Helicobacter felis ( n\u200a=\u200a13) or left uninfected ( n\u200a=\u200a9) during 18 months. Gastritis, amyloid deposition, astroglial and microglial cell area, and systemic and brain cytokines were assessed. The infection ( H. felis&gt; H. pylori) induced a severe gastritis and an increased neuroinflammation but without brain amyloid deposition or systemic inflammation.<\/jats:p>","DOI":"10.3233\/jad-190496","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T10:42:59Z","timestamp":1576579379000},"page":"801-809","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Alzheimer\u2019s Disease and\n                    <i>Helicobacter pylori<\/i>\n                    Infection: Inflammation from Stomach to Brain?"],"prefix":"10.1177","volume":"73","author":[{"given":"Guillaume","family":"Albaret","sequence":"first","affiliation":[{"name":"University of Bordeaux, UMR BaRITOn, INSERM 1053, Bordeaux, France"},{"name":"CHU Bordeaux, P\u00f4le de G\u00e9rontologie Clinique, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Sifr\u00e9","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR BaRITOn, INSERM 1053, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Floch","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR BaRITOn, INSERM 1053, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Laye","sequence":"additional","affiliation":[{"name":"University of Bordeaux, NutriNeuro, INRA 1286, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Aubert","sequence":"additional","affiliation":[{"name":"University of Bordeaux, NutriNeuro, INRA 1286, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Dubus","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR BaRITOn, INSERM 1053, Bordeaux, France"},{"name":"CHU Bordeaux, Service de biologie des tumeurs - tumoroth\u00e8que, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Azzi-Martin","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR BaRITOn, INSERM 1053, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Giese","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR BaRITOn, INSERM 1053, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Salles","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR BaRITOn, INSERM 1053, Bordeaux, France"},{"name":"CHU Bordeaux, P\u00f4le de G\u00e9rontologie Clinique, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"M\u00e9graud","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR BaRITOn, INSERM 1053, Bordeaux, France"},{"name":"CHU Bordeaux, Service de biologie des tumeurs - tumoroth\u00e8que, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Varon","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR BaRITOn, INSERM 1053, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lehours","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR BaRITOn, INSERM 1053, Bordeaux, France"},{"name":"CHU Bordeaux, Service de biologie des tumeurs - tumoroth\u00e8que, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Roubaud-Baudron","sequence":"additional","affiliation":[{"name":"University of Bordeaux, UMR BaRITOn, INSERM 1053, Bordeaux, France"},{"name":"CHU Bordeaux, P\u00f4le de G\u00e9rontologie Clinique, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"key":"ref001","volume-title":"World Alzheimer Report 2015. 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