{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:45:15Z","timestamp":1789026315469,"version":"build-2803163510"},"reference-count":66,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T00:00:00Z","timestamp":1564358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2019,9,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The apolipoprotein E ( APOE) gene \u025b4 allele is a risk factor for Alzheimer\u2019s disease and cardiovascular disease. However, its relationship with cognition and brain volume after stroke is not clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We compared cognition and medial temporal lobe volumes in APOE \u025b4 carriers and non-carriers in the first year after ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We sampled 20 APOE \u025b4 carriers and 20 non-carriers from a larger cohort of 135 ischemic stroke participants in the longitudinal CANVAS study. Participants were matched on a range of demographic and stroke characteristics. We used linear mixed-effect models to compare cognitive domain z-scores (attention, processing speed, executive function, verbal and visual memory, language, visuospatial function) and regional medial temporal lobe volumes (hippocampal, entorhinal cortex) between groups at each time-point (3, 12-months post-stroke), and within groups across time-points. APOE gene single nucleotide polymorphisms (SNPs; rs7412, rs429358) were genotyped on venous blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>APOE \u025b4 carriers and non-carriers did not differ on any demographic, clinical, or stroke variable. Carriers performed worse than non-carriers in verbal memory at 3 months post-stroke ( p\u200a=\u200a0.046), but were better in executive function at 12 months ( p\u200a=\u200a0.035). Carriers demonstrated a significant improvement in verbal memory ( p\u200a=\u200a0.012) and executive function ( p\u200a=\u200a0.015) between time-points. Non-carriers demonstrated a significant improvement in visual memory ( p\u200a=\u200a0.0005). Carriers had smaller bilateral entorhinal cortex volumes ( p\u200a&lt;\u200a0.05), and larger right sided and contralesional hippocampal volumes, at both time-points ( p\u200a&lt;\u200a0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>APOE \u025b4 is associated with delayed recovery of verbal memory function and reduced entorhinal cortex volumes in the first year after ischemic stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-190566","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T11:29:54Z","timestamp":1564486194000},"page":"245-259","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["APOE\n                    <i>\u025b<\/i>\n                    4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke"],"prefix":"10.1177","volume":"71","author":[{"given":"Emilio","family":"Werden","sequence":"first","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Salah","family":"Khlif","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Bird","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Cumming","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Veldsman","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Egorova","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia"},{"name":"Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila K.","family":"Patel","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Gottlieb","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental 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